Electroanalytical Applications Of Quantum Dot Based Biosensors

Quantum dots (QDs) are hybrid organic/inorganic nanoparticles with novel physical properties. QDs have two components: an inorganic core and an optically active coated shell. Moreover, surface coatings can be applied to QDs to modify the particle as needed for experiments. Hydrophilic coatings prevent leaking of metal cargo from the core, enhancing the solubility in biological contexts and bind molecules, such as receptor–ligands, antibodies, therapeutic, and diagnostic macromolecules for enhanced effects. Their high surface-to-volume ratio allows multiple functional groups to attach onto the surface of the particles at constant surface volume. Silicon-, gallium-, indium-, or germanium-based; cadmium-based; and carbon-based QDs have already been used in many applications, such as imaging probes for the engineering of multifunctional nanodevices. Superior properties of QDs make them an excellent system in technology and biotechnology.This book describes electroanalytical applications of QD-based nanobiosensors, including brief information about the synthesis and characterization of QDs and basics of electroanalytical methods, followed by QDs in electrochemical biomimetic sensors, QDs in microchips, inorganic materials doped QDs, QD-based electrochemical DNA biosensors, electroluminescence for biomarker analysis using aptamer-based QDs, QD-based photoelectrochemical techniques, enzyme-based nanobiosensors using QDs, QD-based electrochemical immunosensors, and QD-modified nanosensors in drug analysis. Outlines QD-based applications for drug, food, clinical, and environmental science Shows how the properties of QDs make them effective ingredients in biosensing applications Assesses the major challenges in integrating QDs in biosensing systems

Consisting of six chapters, written by experts in their field, this book charts the progress made in the use of quantum dots as the signaling component in optical sensors since their discovery in the early 1980s. In particular, it focuses on CdS-, CdSe-, and CdTe-type QDs due to their emission in the visible region of the electromagnetic spectrum. The book begins by detailing the range of methods currently used for the preparation and passivation of core/core–shell quantum dots and follows with a discussion on their electrochemical properties and potential toxicity. The book culminates by focusing on how electron and energy transfer mechanisms can be utilized to generate a range of quantum dot-based probes. This is the first text of its kind dedicated to quantum dot-based sensors and will appeal to those readers who have an interest in working with these versatile nanoparticles.

Due to their unique chemical structures and a wide range of biological activities, plenty of nanomaterials based on organic, inorganic, and hybrid compounds have attracted the extensive attention of scientists and made a great contribution to the development of biosensors, diagnosis, and their applications over the past few decades. These kinds of nanomaterials can be utilized as immobilization platforms, optical probes, or (photo)electroactive labels to improve the performance of (bio)sensing devices with higher sensitivity, stability, and selectivity, which undoubtedly revolutionize the way that traditional health monitoring, food safety, environmental research, even emergency security protection are performed.

This book provides a broad introduction to all major aspects of quantum dot properties including fluorescence, electrochemical, photochemical and electroluminescence. Such properties have been produced for applications in biosensing, cell tracking, in vivo animal imaging and so on. It focuses on their special applications in DNA biosensing and provides readers with detailed information on the preparation and functionalization of quantum dots and the fabrication of DNA biosensors, using examples to show how these properties can be used in DNA biosensor design and the advantages of quantum dots in DNA biosensing. Further new emerging quantum dots such as metal nanoclusters and graphene dots and their applications in DNA biosensing have also been included.

Surfactant Based Electrochemical Sensors and Biosensors discusses the applications of surfactants for Electrochemical Sensors. Surfactant based electrochemical sensors exhibits elevated sensitivity, selectivity, stability and accuracy as compared to other analytical techniques. The fabricated sensors can be applied for routine analysis in clinical and industrial samples with acceptable recovery. This book covers the emerging research trends and exploitation of surfactants for electrochemical sensor preparation for its applications in various fields such as academia, medicine, industry and monitoring of environmental species. The key focus of this book is to expand scientific research in the field of electrochemistry on surfactant based electrochemical sensors in order to construct highly sensitive devices. Part one presents the characteristics of surfactants and discusses their application for the fabrication of electrochemical sensors and bio sensors. Part two addresses the analysis of toxic chemicals and their quantitative determination and offers surfactant based sensing platforms for environmental modelling. Part three discusses the significance of the analysis of molecules and ions in biological and pharmaceutical sampling. Part four presents new methodologies for the determination of food additives and biological molecules present in food samples. Part 5 explores the Sustainability, Safety and Toxicity Aspects of Surfactant Modified Electrochemical Sensors and Biosensors. Presents emerging research trends and discusses the exploitation of surfactants for electrochemical sensor preparation and its applications for multi-disciplinary fields Addresses the development process for a sensitive, robust, and responsive sensor with the use of surfactants Presents the utilization of surfactant based sensors in real-time analysis

Novel Nanostructured Materials for Electrochemical Bio-sensing Applications presents a detailed overview into the fabrication of electrochemical bio-sensing devices. The book addresses the challenges and opportunities relating to sustainable and biocompatible sensors from food, water and wearable applications to the various nanostructured biocompatible materials required for sensor fabrication. In addition, it explores the connection between nanomaterials and sensors and takes into consideration different and novel approaches such as toxic materials monitoring and health issues correlated with the use of nanomaterials. Users will find exciting insight into innovations in nanostructured electrochemical biosensing. By providing its audience with fundamentals, limitations, challenges, future perspectives and practical sustainability, this book will serve as a reference source researchers and engineers within analytical chemistry and electrochemistry. Showcases the latest progress in new nanostructured materials, bio-sensing types and applications Provides a comparative vision of electrochemical bio-sensing with other biosensors Discusses the economics, commercialization, toxicity and life line aspects of electrochemical biosensors

Biosensors: Fundamentals, Emerging Technologies, and Applications provides insight into the sensing applications of different types of biosensors relating to environmental pollutants, microbiological analysis, and healthcare. It describes state-of-the-art research in biosensors, point of care testing, potential applications, as well as future prospects for biosensors. This book: Presents the essentials that readers need to know to make full use of biosensor technology Discusses recent perspectives on optical and electrochemical biosensors Details biosensor types for medical applications Teaches how to use enzymes for biological recognition in biomarker assays Proposes innovations in wearable and smart biosensors This book is aimed at advanced students, researchers, and academics across a broad interdisciplinary field including biochemical, pharmaceutical, and environmental engineering as well as materials science, analytical chemistry, and biosciences.

Nowadays, the implementation of novel technological platforms in biosensor-based developments is primarily directed to the miniaturization of analytical systems and lowering the limits of detection. Rapid scientific and technological progress enables the application of biosensors for the online detection of minute concentrations of different chemical compounds in a wide selection of matrixes and monitoring extremely low levels of biomarkers even in living organisms and individual cells. This book, including 16 chapters, characterizes the present state of the art and prospective options for micro and nanoscale activities in biosensors construction and applications.