Engineering Bio Terror Agents

In recent years much has happened to justify an examination of biological research in light of national security concerns. The destructive application of biotechnology research includes activities such as spreading common pathogens or transforming them into even more lethal forms. Policymakers and the scientific community at large must put forth a vigorous and immediate response to this challenge. This new book by the National Research Council recommends that the government expand existing regulations and rely on self-governance by scientists rather than adopt intrusive new policies. One key recommendation of the report is that the government should not attempt to regulate scientific publishing but should trust scientists and journals to screen their papers for security risks, a task some journals have already taken up. With biological information and tools widely distributed, regulating only U.S. researchers would have little effect. A new International Forum on Biosecurity should encourage the adoption of similar measures around the world. Seven types of risky studies would require approval by the Institutional Biosafety Committees that already oversee recombinant DNA research at some 400 U.S. institutions. These "experiments of concern" include making an infectious agent more lethal and rendering vaccines powerless.

The threat of domestic terrorism today looms larger than ever. Bombings at the World Trade Center and Oklahoma City's Federal Building, as well as nerve gas attacks in Japan, have made it tragically obvious that American civilians must be ready for terrorist attacks. What do we need to know to help emergency and medical personnel prepare for these attacks? Chemical and Biological Terrorism identifies the R&D efforts needed to implement recommendations in key areas: pre-incident intelligence, detection and identification of chemical and biological agents, protective clothing and equipment, early recognition that a population has been covertly exposed to a pathogen, mass casualty decontamination and triage, use of vaccines and pharmaceuticals, and the psychological effects of terror. Specific objectives for computer software development are also identified. The book addresses the differences between a biological and chemical attack, the distinct challenges to the military and civilian medical communities, and other broader issues. This book will be of critical interest to anyone involved in civilian preparedness for terrorist attack: planners, administrators, responders, medical professionals, public health and emergency personnel, and technology designers and engineers.

The use of and problems associated with biological weapons have been of concern to NATO and non-NATO military organizations for many years. Until recently, most of the readily available literature addressed the military issues associated with the possible use of biological weapons on the battlefield, the medical effects of the various agents, and what was known about medical prophylaxis and treatments. Information on other needed countermeasures, such as decontamination, or public health issues associated with exposure of civilian populations, were largely overlooked. This perspective changed dramatically after the contamination of the US Mail system with powdered anthrax spores. Among the significant problems and defensive weaknesses that the anthrax attack revealed was the importance, but lack of established industrial-scale decontamination methods for large volumes of heterogeneous objects or for complex physical environments. Ultimately, these two microbial decontamination problems were solved in very different ways. The contaminated mail was treated with ionizing radiation while the contaminated government buildings were treated with vapor / gas-phase chemicals. Both the decontamination of the mail and establishing a process for prophylactic treatment of the mail, were solved relatively quickly. This was in large part due to the robust radiation biology and technical base derived from the industrial use of ionizing radiation. Contributing to the speed of response was the fact that the attack occurred within the United States and in the 'home town' of many of the technical experts and decision makers, allowing official response to be coordinated rapidly.

The attacks of September 11 and the release of anthrax spores revealed enormous vulnerabilities in the U.S. public-health infrastructure and suggested similar vulnerabilities in the agricultural infrastructure as well. The traditional public health response-surveillance (intelligence), prevention, detection, response, recovery, and attribution-is the paradigm for the national response not only to all forms of terrorism but also to emerging infectious diseases. Thus, investments in research on bioterrorism will have enormous potential for application in the detection, prevention, and treatment of emerging infectious diseases that also are unpredictable and against which we must be prepared. The deciphering of the human genome sequence and the complete elucidation of numerous pathogen genomes, our rapidly increasing understanding of the molecular mechanisms of pathogenesis and of immune responses, and new strategies for designing drugs and vaccines all offer unprecedented opportunities to use science to counter bioterrorist threats. But these same developments also allow science to be misused to create new agents of mass destruction. Hence the effort to confront bioterrorism must be a global one. Countering Bioterrorism makes the following recommendations: Recommendation 1: All agencies with responsibility for homeland security should work together to establish stronger and more meaningful working ties between the intelligence, S&T, and public health communities. Recommendation 2: Federal agencies should work cooperatively and in collaboration with industry to develop and evaluate rapid, sensitive, and specific early-detection technologies. Recommendation 3: Create a global network for detection and surveillance, making use of computerized methods for real-time reporting and analysis to rapidly detect new patterns of disease locally, nationally, and ultimately- internationally. The use of high-throughput methodologies that are being increasingly utilized in modern biological research should be an important component of this expanded and highly automated surveillance strategy. Recommendation 4: Use knowledge of complex biological patterns and high-throughput laboratory automation to classify and diagnose infections in patients in primary care settings. Recommendation 5: USDA should create an agency for control and prevention of plant disease. This agency should have the capabilities necessary to deal effectively with biothreats.

Hospital Preparation for Bioterror provides an extremely timely guide to improving the readiness of hospitals or healthcare organizations to manage mass casualties as a result of bioterrorism, biological warfare, and natural disasters. Contributions from leading law enforcement agencies, hospital administrators, clinical engineers, surgeons and terror-prevention professionals provide the most comprehensive, well-rounded source for this valuable information. Chapters on logistics and protecting the infrastructure help personnel distinguish the specific risks and vulnerabilities of each unique institution and assists in identifying specific solutions for disaster and bioterrorism preparedness. Principles and techniques discussed are applicable to all disasters, both large and small, not just bioterrorism. Technical aspects such as hospital power and telecommunications are covered, in addition to patient care, response to mass casualties, large-scale drills, and surge capacity. Organized along functional lines, patient flow, medical specialty, and infrastructure. A complimentary website with supplementary materials, check-lists, and references enhances the text and provides additional resources for preparedness.

This book summarises the lectures presented at the Centre of Excellence - Defence Against Terrorism (COE-DAT) workshop on Bioterrorism of November 2008. The contributors are a diverse group of academics and practitioners, selected for their expertise in the field. Their contributions cover the definition and classification of bioterrorism and take account of its various dimensions, examining the theoretical, historical and practical aspects, as well as the defence against it. Consisting of seven papers and four summaries, the book covers subjects such as biodiversity, the historical use of biological agents and the concern for public safety, the role of the International Science & Technology Center in countering bioterrorism, the Global Forum on Biorisks, threat assessment, animal health and disease with reference to biological safety and the Biological Weapons Convention. The workshop itself was of necessity restricted to a small number of participants, but with this book, research, experience and perspectives on biological risks can be shared with a wider audience, allowing further consideration and improvements in countering risks and responding to biological threats and attacks. Inaugurated in 2005, COE-DAT is a NATO accredited Centre of Excellence; a unique centre dedicated to Defence Against Terrorism, which provides DAT training and education at strategic and operational levels and contributes to research efforts. IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields. Some of the areas we publish in: -Biomedicine -Oncology -Artificial intelligence -Databases and information systems -Maritime engineering -Nanotechnology -Geoengineering -All aspects of physics -E-governance -E-commerce -The knowledge economy -Urban studies -Arms control -Understanding and responding to terrorism -Medical informatics -Computer Sciences