Epic Measures

Moneyball meets medicine in this remarkable chronicle of one of the greatest scientific quests of our time and the visionary mastermind behind it. Medical doctor and economist Christopher Murray began the Global Burden of Disease study to gain a truer understanding of how we live and how we die. While it is one of the largest scientific projects ever attempted—as breathtaking as the first moon landing or the Human Genome Project—the questions it answers are meaningful for every one of us: What are the world's health problems? Who do they hurt? How much? Where? Why? Murray argues that the ideal existence isn't simply the longest, but the one lived well and with the least illness. Until we can accurately measure global health issues, we cannot understand what makes us sick or do much to improve it. Challenging the accepted wisdom of the WHO and the UN, the charismatic and controversial health maverick has made enemies—as well as some influential friends, including Bill Gates who gave Murray a $100 million grant. Told with novelistic verve by acclaimed journalist Jeremy N. Smith, the story of Murray's lifelong determination to understand how we live and die encompasses wars and famines, presidents and activists, billionaires and billions of people worldwide living in poverty. It shows the human side of scientific revolutions and of revolutionary scientists—their breakthroughs and setbacks, their genius and their flaws, their champions and their critics—as they strive to bring the news of their findings to the world. This transformational effort is far from over, but the story of its genesis and impact is already an epic tale.

Explains how to keep track of the parts of the day with a clock; describes the development of the sundial, the hourglass, and the clock; and discusses minutes and seconds, telling time, analog and digital timepieces, and ways to express the time.

Provide young readers with a better understanding of what causes these weather events and how to stay safe should a dangerous situation arise. With simple text and large, outstanding photos, readers will not only be informed, but also gain an appreciation of these awesome phenomenons.

Real-world examples and engaging activities guide readers in learning about measuring weight. Readers practice selecting appropriate measuring tools and units of measurement, converting between units, and solving problems by measuring.

Real-world examples and engaging activities guide readers in learning about measuring volume. Readers practice selecting appropriate measuring tools and units of measurement, converting between units, and solving problems by measuring.

Longitudinal models play a very important role in marketing model building, and there are some occasions when market research is conducted every day of the year. These longitudinal models can be useful to marketing managers to make many informed and important decisions for optimal allocation of resources to marketing mix variables. In particular, we cover three major applications of these principles adhering to Advertising tracking monitors, Brand Equity monitors, and sales promotion monitors. We introduce the reader to the basic principles and theory of econometrics in model building for analyzing sales and market share variables about marketing spending. Different functional forms are discussed in the book. And the readers are encouraged to use these functional forms to model the three monitors mentioned above. This book is targeted towards second-year MBA students and marketing/brand managers in companies to derive insights about the markets and competitors. This is followed up with different tools for forecasting companies' sales and market share. This book is useful for managers in durables and fast-moving consumer goods industries. This book addresses the need for when and where to make insights about marketing mix variables through econometric models. The author has 32 years of industry experience and is an expert in marketing models. The author has a Ph.D. in marketing from Purdue University. The book elucidates these theories without using complicated mathematical equations in simple-to-understand verbal models of complicated equations.

Prostate Cancer, Science and Clinical Practice, Second Edition, continues to be an important translational reference that bridges the gap between science and clinical medicine. It reviews the biological processes that can be implicated in the disease, reviews current treatments, highlights the pitfalls where relevant, and examines the scientific developments that might result in future treatments. Key chapters from the previous edition have been updated, and a plethora of new chapters describe new concepts of prostate cancer biology and newly developed therapeutics. Each chapter has been written by internationally recognized specialists on prostate cancer epidemiology, genetic susceptibility, cancer metastases, prostate physiology, proteomics, new therapeutics, and clinical trials. Presents a comprehensive, translational source for all aspects of prostate cancer in one reference work Provides a common language for cancer researchers, oncologists, and urologists to discuss prostate tumors and how prostate cancer metastases affects other major organ systems Offers insights to research clinicians, giving them a key understanding the molecular basis of prostate cancer Offers insights to cancer researchers into how clinical observations and practices can feed back into the research cycle and, therefore, can contribute to the development of more targeted genomic and proteomic assays