Essentials Of Neural Development

How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

In a remarkable synthesis of the research of the last two decades, a leading developmental neuroscientist provides psychologists with a sophisticated introduction to the brain—the system that underpins the functions that they study. In clear terms, with ample illustrations, Joan Stiles explains the complexities of genetic variation and transcription, and the variable paths of neural development, from embryology through early childhood. She describes early developmental processes from gene expression to physiology to behavior. Sections on clinical correlations show the consequences for later physiological, neurological, or psychological disturbances in neural development. As Stiles shows, brain development is far more complex and dynamic than is often assumed in debates about nature vs. nurture, nativism vs. cultural learning. Inherited and experienced factors interact constantly in an ever-changing organism. The key question is, what developmental processes give rise to particular structures or mechanisms? A landmark of synthesis and interdisciplinary illumination, The Fundamentals of Brain Development will enrich discussion of developmental processes and more rigorously define the terms that are central to psychological debates.

The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 3 sections include coverage of: mechanisms that control the assembly of neural circuits in specific regions of the nervous system, multiple aspects of cognitive development, and disorders of the nervous system arising through defects in neural development

This book reviews recent progress in cortical development research, focusing on the mechanisms of neural stem cell regulation, neuronal diversity and connectivity formation, and neocortical organization. Development of the cerebral cortex, the center for higher brain functions such as cognition, memory, and decision making, is one of the major targets of current research. The cerebral cortex is divided into many areas, including motor, sensory, and visual cortices, each of which consists of six layers containing a variety of neurons with different activities and connections. As this book explains, such diversity in neuronal types and connections is generated at various levels. First, neural stem cells change their competency over time, giving sequential rise to distinct types of neurons and glial cells: initially deep layer neurons, then superficial layer neurons, and lastly astrocytes. The activities and connections of neurons are further modulated via interactions with other brain regions, such as the thalamocortical circuit, and via input from the environment. This book on cortical development is essential reading for students, postdocs, and neurobiologists.

In a remarkable synthesis of the research of the last two decades, a leading developmental neuroscientist provides psychologists with a sophisticated introduction to the brain—the system that underpins the functions that they study. In clear terms, with ample illustrations, Joan Stiles explains the complexities of genetic variation and transcription, and the variable paths of neural development, from embryology through early childhood. She describes early developmental processes from gene expression to physiology to behavior. Sections on clinical correlations show the consequences for later physiological, neurological, or psychological disturbances in neural development. As Stiles shows, brain development is far more complex and dynamic than is often assumed in debates about nature vs. nurture, nativism vs. cultural learning. Inherited and experienced factors interact constantly in an ever-changing organism. The key question is, what developmental processes give rise to particular structures or mechanisms? A landmark of synthesis and interdisciplinary illumination, The Fundamentals of Brain Development will enrich discussion of developmental processes and more rigorously define the terms that are central to psychological debates.

Foundations of Neural Development is an accessible textbook, written with a conversational style and topics appropriate for an undergraduate audience. Each chapter begins with a thought-provoking vignette, or a real-life story, that the subsequent material illuminates. The “Researchers at Work” feature, available in every chapter, describes a classic study in detail, taking the reader through the hypothesis, test, result, and conclusion of an experiment. Other features include a marginal glossary, review questions, and bulleted summary in each chapter. Chapters 1–7 unfold in the order of ontogeny, covering induction, the establishment of a body plan, neural migration, differentiation, axonal pathfinding, synapse formation, and apoptosis. Chapters 8–10 address activity-guided, experience-guided, and socially guided neural development—mechanisms that were crucial for the evolution of the human brain. Lively and engaging, with the finest illustrations, this is the perfect book to help any undergraduate student understand how a single microscopic cell, a human zygote, can develop into the most complex machine on earth, the brain./div