Ether Day

A fascinating and entertaining look at the men behind the first surgical use of anesthesia—and the price they paid for their breakthrough. On Friday, October 16, 1846, only one operation was scheduled at Massachusetts General Hospital.... That day in Boston, the operation was the routine removal of a growth from a man's neck. But one thing would not be routine: instead of using pulleys, hooks, and belts to subdue a patient writhing in pain, this crucial operation would be the first performed under a general anesthetic. No one knew whether the secret concoction would work. Some even feared it might kill the patient. This engrossing book chronicles what happened that day and during its dramatic aftermath. In a vivid history that is stranger than fiction, Ether Day tells the story of the three men who converged to invent the first anesthesia—and the war of ego and greed that soon sent all three men spiraling wildly out of control.

Edited and written by an international "who's who" of more than 100 authors, including anesthesiologists, nurse anesthetists, bench scientists, a surgeon, and representatives of industry, this text provides a comprehensive history of anesthesia, unique in its focus on the people and events that shaped the specialty around the world, particularly during the past 70 years when anesthesia emerged from empiricism and developed into a science-based practice.

Among all the great discoveries and inventions of the nineteenth century, few offer us a more fascinating insight into Victorian society than the discovery of anaesthesia. Now considered to be one of the greatest inventions for humanity since the printing press, anaesthesia offered pain-free operations, childbirth with reduced suffering, and instant access to the world beyond consciousness. And yet, upon its introduction, Victorian medics, moralists, clergymen, and scientists, were plunged into turmoil. This vivid and engaging account of the early days of anaesthesia unravels some key moments in medical history: from Humphry Davy's early experiments with nitrous oxide and the dramas that drove the discovery of ether anaesthesia in America, to the outrage provoked by Queen Victoria's use of chloroform during the birth of Prince Leopold. And there are grisly ones too: frequent deaths, and even notorious murders. Interweaved throughout the story, a fascinating social change is revealed. For anaesthesia caused the Victorians to rethink concepts of pain, sexuality, and the links between mind and body. From this turmoil, a profound change in attitudes began to be realised, as the view that physical suffering could, and should, be prevented permeated through society, most tellingly at first in prisons and schools where pain was used as a method of social control. In this way, the discovery of anaesthesia left not only a medical and scientific legacy that changed the world, but a compassionate one too.

The story of America's first major scientific discovery -- the use of anesthesia Traces the dawn of modern surgery through the lives of 3 extraordinary men. Ironically, ether & nitrous oxide had been known for more than 40 years to cause insensitivity to pain, yet, with names like laughing gas,Ó they were used almost solely for entertainment. The breakthrough finally came about as a Boston dentist crossed paths with a colleague from Hartford & a Harvard-trained physician: William Morton, Horace Wells, & Charles Jackson. Though Wells was crushed by derision when he tried to introduce anesthetics, Morton prevailed, with help from Jackson. The result was Ether Day, Oct. 16, 1846, celebrated around the world. Illustrations.

The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful.