Evolution Of Organismal Form From Regulatory Interactions To Developmental Processes And Biological Patterns

Today's biodiversity is the spectacular product of hundreds of millions of years of evolution. Understanding how this diversity of living organisms appeared is one of the most intriguing and challenging question in biology. Because organismal morphology is established during embryonic development, and because morphological traits diversified from ancestral forms during evolution, it can be inferred that changes in the mechanisms controlling embryonic development are instrumental for morphological evolution. This syllogism lies at the very heart of a new discipline called Evo-Devo which is centered in the identification of the cellular and genetic mechanisms that, through modifications in developmental programmes, were at the base of morphological innovations during evolution. After the discovery of the broad conservation of gene content and regulatory networks in the animal kingdom, as well as in plants, Evo-Devo is orienting towards the study of differences through experimental and functional approaches. Given the wide range of species, gene families, and developmental processes considered, a concerted effort is still required to shed light on the genetic, cellular and molecular mechanisms involved in phenotypic evolution. It is a particularly exciting time for this field of evolutionary developmental biology, as the advent of novel imaging, genome editing and sequencing technologies allows the study of almost any organism in ways that were unthinkable only a few years ago. Therefore, the aim of this Frontiers Research Topic is to gather an original collection of experimental approaches, concepts and hypotheses reflecting the current diversity of the Evo-Devo field. We have organized the articles according to the mechanistic depth with which they tackle specific evolutionary issues. Hence, comparisons of expression patterns have been grouped in Chapter 1, changes in regulatory interactions and gene networks are presented in Chapter 2, while Chapter 3 focuses on the evolution of developmental processes and biological patterns.

Today's biodiversity is the spectacular product of hundreds of millions of years of evolution. Understanding how this diversity of living organisms appeared is one of the most intriguing and challenging question in biology. Because organismal morphology is established during embryonic development, and because morphological traits diversified from ancestral forms during evolution, it can be inferred that changes in the mechanisms controlling embryonic development are instrumental for morphological evolution. This syllogism lies at the very heart of a new discipline called Evo-Devo which is centered in the identification of the cellular and genetic mechanisms that, through modifications in developmental programmes, were at the base of morphological innovations during evolution. After the discovery of the broad conservation of gene content and regulatory networks in the animal kingdom, as well as in plants, Evo-Devo is orienting towards the study of differences through experimental and functional approaches. Given the wide range of species, gene families, and developmental processes considered, a concerted effort is still required to shed light on the genetic, cellular and molecular mechanisms involved in phenotypic evolution. It is a particularly exciting time for this field of evolutionary developmental biology, as the advent of novel imaging, genome editing and sequencing technologies allows the study of almost any organism in ways that were unthinkable only a few years ago. Therefore, the aim of this Frontiers Research Topic is to gather an original collection of experimental approaches, concepts and hypotheses reflecting the current diversity of the Evo-Devo field. We have organized the articles according to the mechanistic depth with which they tackle specific evolutionary issues. Hence, comparisons of expression patterns have been grouped in Chapter 1, changes in regulatory interactions and gene networks are presented in Chapter 2, while Chapter 3 focuses on the evolution of developmental processes and biological patterns.

A more comprehensive version of evolutionary theory that focuses as much on the origin of biological form as on its diversification. The field of evolutionary biology arose from the desire to understand the origin and diversity of biological forms. In recent years, however, evolutionary genetics, with its focus on the modification and inheritance of presumed genetic programs, has all but overwhelmed other aspects of evolutionary biology. This has led to the neglect of the study of the generative origins of biological form. Drawing on work from developmental biology, paleontology, developmental and population genetics, cancer research, physics, and theoretical biology, this book explores the multiple factors responsible for the origination of biological form. It examines the essential problems of morphological evolution—why, for example, the basic body plans of nearly all metazoans arose within a relatively short time span, why similar morphological design motifs appear in phylogenetically independent lineages, and how new structural elements are added to the body plan of a given phylogenetic lineage. It also examines discordances between genetic and phenotypic change, the physical determinants of morphogenesis, and the role of epigenetic processes in evolution. The book discusses these and other topics within the framework of evolutionary developmental biology, a new research agenda that concerns the interaction of development and evolution in the generation of biological form. By placing epigenetic processes, rather than gene sequence and gene expression changes, at the center of morphological origination, this book points the way to a more comprehensive theory of evolution.

Evolutionary developmental biology, or 'evo-devo', is the study of the relationship between evolution and development. Dealing specifically with the generative mechanisms of organismal form, evo-devo goes straight to the core of the developmental origin of variation, the raw material on which natural selection (and random drift) can work. Evolving Pathways brings together contributions that represent a diversity of approaches. Topics range from developmental genetics to comparative morphology of animals and plants alike, and also include botany and palaeontology, two disciplines for which the potential to be examined from an evo-devo perspective has largely been ignored until now. Researchers and graduate students will find this book a valuable overview of current research as we begin to fill a major gap in our perception of evolutionary change.

Rudolf Raff is recognized as a pioneer in evolutionary developmental biology. In their 1983 book, Embryos, Genes, and Evolution, Raff and co-author Thomas Kaufman proposed a synthesis of developmental and evolutionary biology. In The Shape of Life, Raff analyzes the rise of this new experimental discipline and lays out new research questions, hypotheses, and approaches to guide its development. Raff uses the evolution of animal body plans to exemplify the interplay between developmental mechanisms and evolutionary patterns. Animal body plans emerged half a billion years ago. Evolution within these body plans during this span of time has resulted in the tremendous diversity of living animal forms. Raff argues for an integrated approach to the study of the intertwined roles of development and evolution involving phylogenetic, comparative, and functional biology. This new synthesis will interest not only scientists working in these areas, but also paleontologists, zoologists, morphologists, molecular biologists, and geneticists.

Leading researchers in evolutionary developmental biology seek linkages between, and a synthesis of, development, physiology, endocrinology, ecology, and evolution. Evolutionary developmental biology, also known as evo-devo or EDB, seeks to find links between development and evolution by opening the "black box" of development's role in evolution and in the evolution of developmental mechanisms. In particular, this volume emphasizes the roles of the environment and of hormonal signaling in evo-devo. It brings together a group of leading researchers to analyze the dynamic interaction of environmental factors with developmental and physiological processes and to examine how environmental signals are translated into phenotypic change, from the molecular and cellular level to organisms and groups of organisms. Taken together, these chapters demonstrate the crucial roles of those processes of genetic, developmental, physiological, and hormonal change that underpin evolutionary change in development, morphology, physiology, behavior, and life-history. Part I investigates links between environmental signals and developmental processes that could be preserved over evolutionary time. Several contributors evaluate the work of the late Ryuichi Matsuda, especially his emphasis on the role of the external environment in genetic change and variability ("pan-environmentalism"). Other contributors in part I analyze different aspects of environmental-genetic-evolutionary linkages, including the importance of alternate ontogenies in evolution and the paradox of stability over long periods of evolutionary time. Part II examines the plasticity that characterizes much of development, with contributors discussing such topics as gene regulatory networks and heterochronicity. Part III analyzes the role of hormones and metamorphosis in the evolution of such organisms with alternate life-history stages as lampreys, amphibians, and insects.

Although evolutionary developmental biology is a new field, its origins lie in the last century; the search for connections between embryonic development (ontogeny) and evolutionary change (phylogeny) has been a long one. Evolutionary developmental biology is however more than just a fusion of the fields of developmental and evolutionary biology. It forges a unification of genomic, developmental, organismal, population and natural selection approaches to evolutionary change. It is concerned with how developmental processes evolve; how evolution produces novel structures, functions and behaviours; and how development, evolution and ecology are integrated to bring about and stabilize evolutionary change. The previous edition of this title, published in 1992, defined the terms and laid out the field for evolutionary developmental biology. This field is now one of the most active and fast growing within biology and this is reflected in this second edition, which is more than twice the length of the original and brought completely up to date. There are new chapters on major transitions in animal evolution, expanded coverage of comparative embryonic development and the inclusion of recent advances in genetics and molecular biology. The book is divided into eight parts which: place evolutionary developmental biology in the historical context of the search for relationships between development and evolution; detail the historical background leading to evolutionary embryology; explore embryos in development and embryos in evolution; discuss the relationship between embryos, evolution, environment and ecology; discuss the dilemma for homology of the fact that development evolves; deal with the importance of understanding how embryos measure time and place both through development and evolutionarily through heterochrony and heterotrophy; and set out the principles and processes that underlie evolutionary developmental biology. With over one hundred illustrations and photographs, extensive cross-referencing between chapters and boxes for ancillary material, this latest edition will be of immense interest to graduate and advanced undergraduate students in cell, developmental and molecular biology, and in zoology, evolution, ecology and entomology; in fact anyone with an interest in this new and increasingly important and interdisciplinary field which unifies biology.