Expanding Horizons In Atherosclerosis Research

On 29 February 1964, a group of European scientists met in Paris to discuss a subject of common interest, namely atherosclerosis research, with particular reference to international communication and collaboration. After a second meeting on 15 May 1964, they founded the European Atherosclerosis Group which was to com prise individuals engaged in the various disciplines of atherosclero sis research in Eastern and Western Europe. Since then this group has initiated multidisciplinary discussion and scientific collabora tion across Europe, in accordance with the objects and aims written in its statutes: 1. To hold colloquia and symposia dealing with research in the field of atherosclerosis and allied sciences 2. To encourage meetings and exchanges between scientists in the group engaged in the investigation of atherosclerosis 3. To encourage collaborative work between national and interna tional centers engaged in atherosclerosis research 4. To encourage the publication of reviews, etc. , on atherosclerosis research which may be considered of value 5. To promote research fellowships, particularly for younger research workers, for studies within the field of atherosclerosis and allied sciences 6. To accept dues, endowments, grants, funds, and bequests to be used for the above purposes The European Atherosclerosis Group has helped to bring together what was separated during the second world war and the postwar period in Europe and to reestablish ties with the leading American teams.

Dietary Proteins and Atherosclerosis provides a thorough review of the role of proteins in the development of atherosclerosis. The author reviews early research connections between dietary fat and cardiovascular disease caused by the build-up of plaque in arteries and examines other factors that contribute to atherosclerosis, such as infection and

Plasma lipoproteins constitute a unique macromolecular system of lipid-protein complexes responsible for the transport of lipids from their sites of origin to their sites of utilization either as metabolic fuel or as structural components of cell membranes. Although studies on the role of lipoproteins in the mechanism of lipid transport are meritorious in their own right, the ever-increasing interest in chemical and functional properties of this remarkable class of conjugated proteins stems from the impressive evidence of their direct involvement in the genesis and develop ment of atherosclerotic lesions. The initial emphasis on neutral lipids and phospholipids as the most characteristic constituents of operationally defined lipoprotein classes has shifted in recent years to their protein moieties or apolipoproteins. The discovery of a number of apolipoproteins and characterization of familial hypolipoproteinemias as apolipoprotein deficiency disorders indicated that apolipoproteins play an essential role in maintaining the structural stability and integrity of lipoprotein particles. In addition to their role in the formation of lipoproteins, apolipoproteins were shown to perform a variety of functions in metabolic conversion of lipoproteins and their interactions with cellular surfaces. Results from several laboratories have demonstrated that the chemical and metabolic heterogeneity of operationally-defined lipoprotein classes is due to the presence of several discrete lipoprotein particles with similar physical properties but different and characteristic apolipoprotein composition. Thus, the apolipoproteins have emerged not only as essential structural and functional constituents of lipoproteins but also as unique chemical markers for identifying and classifying lipoprotein particles.

Major epidemiologists from the UK, USA and Europe contribute to the first ever, much needed comprehensive review of the epidemiology of peripheral vascular disease in the lower limbs.

Revised and expanded, this edition provides comprehensive coverage of occupational health and safety. A new CD-ROM version is available which provides the benefits of computer-assisted search capabilities

First multi-year cumulation covers six years: 1965-70.