Experimental And Clinical Neuropathology

From reviews of the First Edition: "Being a concise introduction to the principles of neruopathology is a goal this book accomplishes admirably." Annals of Neurology; "unquestionably valuable as a reference text" Arch Path Lab Med; "a fine treatise which truly reflects the current knowledge of the discipline with a strong emphasis on morphologic aspects" Brain Pathology; "an excellent current reference work on neuropathology for practitioners in the various clinical and basic neurosciences" Journal of Neuropathology and Experimental Neurology.

Parkinson's disease is the second most common neurodegenerative disorder in the world after Alzheimer's disease. Thanks to the pioneering works of Arvid Carlson in the 20th century identifying dopamine as the main neurochemical agent involved in Parkinson's disease's onset and progress, our understanding of the neuropathology has increased. The elaboration of L-Dopa as the first pharmacological treatment approach has brought new hope for curing or at least slowing the neurodegenerative progress and the decline of motor and cognitive functions in Parkinson's disease patients. To date, imaging techniques along with genetic and biochemical tools have allowed scientists and clinicians to predict and diagnose the disease several years prior to the motor disorder's appearance. Experimental and Clinical Evidence of the Neuropathology of Parkinson's Disease sheds light on the history of Parkinson's disease as well as the recent literature on the epidemiological data worldwide including the prevalence of the disease, the morbimortality rates, and the sex dimorphism and aging components. It addresses the current neuropathological evidence of Parkinson's disease, including the latest discoveries in terms of neuropathology and treatments available or under clinical trials with the efficacy and limitations of each. Covering topics such as epidemiology, stem cells, and neuropathology, this premier reference source is an excellent resource for clinicians, physicians, epidemiologists, neuroscientists, microbiologists, biochemists, pharmacologists, toxicologists, medical professionals, nurses, medical students and educators, librarians, researchers, and academicians.

Now in its 5th edition, Escourolle & Poirier Manual of Basic Neuropathology continues the tradition of being one of the most respected texts in neuropathology by providing an introduction to the various diseases of the nervous system and their underlying pathology. This thorough, yet concise manual covers the full spectrum of the various categories of neurologic disease, including neoplasia, trauma, vascular disease, and infection, with separate chapters on prion diseases, multiple sclerosis, degenerative disorders, acquired metabolic diseases, hereditary metabolic diseases, congenital malformations, perinatal diseases, skeletal muscle, peripheral nerve, and the pituitary gland. To accurately guide the clinician, the most current techniques in neuropathology are covered in their own chapter at the end of the book. Richly illustrated throughout, with over 700 images of various neuropathogical diagnoses such as tumor, stroke, infection, degeneration, and malformation among others, this new edition of the classic monograph is an easy-to-use manual for any student, researcher, or practitioner seeking basic information on neuropathology. Used for decades in all fields related to the nervous system-including neurology, neurosurgery, psychiatry, neuroradiology, neuroendocrinology, neuropathology, pathology, and neuroscience- Escourolle & Poirier Manual of Basic Neuropathology is regarded at the 'bible' of neuropathology. This new version has been completely rewritten and expanded to include important updates in genetics and molecular biology, reflective of the important neuropathological discoveries in those fields over the past decade.This book is a practical diagnostic tool and necessary reading for anyone encountering pathological conditions of the nervous system.