Female Sex Steroids

It is the object of this series of monographs to present the experiments and interpre tations of a given laboratory. We have attempted in this volume to present our view of receptor-steroid interactions and their relation to steroid-induced responses. This view is necessarily biased by our own experimental results. While we have tried to in clude the views and results of others, this volume is not meant to be comprehensive. Rather it is selective and examines those topics within the general field of steroid hor mone action which we have addressed at the laboratory bench. The work reviewed in this volume would not exist without the help and support of many associates. Our mentors included Jorge Awapara, Jack Gorski, Henry Komer, Bill Ray, and Mike Zarrow. Associates instrumental in this work include George Barr, John Burgner, Sam Campbell, Constance Cardasis, Hitkan Eriksson, Stan Glasser, Jim Hardin, Mohammed Kalimi, Bruce Lester, Barry Markavarich, Shirley McCormick, Tony Means, Dan Medina, Ann Miller, Bert O'Malley, Helen Padyku la, Zigmund Paszko, Dale Snow, Susan Upchurch and Marian Walters. Students who have contributed to this effort include John Anderson, Joe DeLibero, Aaron Hsueh, Katrina Kelner, Debbie Metzger, Randy Richards, Jim Schaeffer, Mike Tytell, Lane von Brunt, and Cheryl Watson. Technicians without whose assistance this work could not exist include Toni Cetti, Wendy D'Attilio, Jeanie Haselby, Lily Hsueh, Helen Hyland, Jim Kovar, Kathy O'Connor, and Peggy Sansone."

Now in a revised and expanded second edition including seven brand new chapters, this book compiles and synthesizes the latest research and clinical evidence regarding the intricate relationship between sex hormones and the physical activity level and overall health of the female endocrine system across the lifespan. Expert authors from around the world discuss in detail the impact of sex hormones on energy metabolism, cardiorespiratory system, nervous system, and musculoskeletal health, as well as environmental and psychological factors affecting exercise and sexual health. Considerations of the hormonal and physiological changes to the menstrual cycle and in menopause due to exercise receive chapters of their own. New to this edition are discussions of pregnancy, menopause, aerobic endurance training, the transgender athlete, sports performance, and the future of sports and exercise science relating to the active female. Covering a hot topic in sports medicine and science, Sex Hormones, Exercise and Women, Second Edition will be of interest to researchers, clinicians, exercise scientists, and residents and fellows in these areas.

Research on health involves evaluating the disparities that are systematically associated with the experience of risk, including genetic and physiological variation, environmental exposure to poor nutrition and disease, and social marginalization. This volume provides a unique perspective - a comparative approach to the analysis of health disparities and human adaptability - and specifically focuses on the pathways that lead to unequal health outcomes. From an explicitly anthropological perspective situated in the practice and theory of biosocial studies, this book combines theoretical rigor with more applied and practice-oriented approaches and critically examines infectious and chronic diseases, reproduction, and nutrition.

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.

Steroid Hormone Action is a comprehensive overview of the molecular mechanisms by which these hormones regulate the expression of specific target genes. The book covers the structure of steroid receptors, transcriptional activation and repression, and also contains chapters on steroid bindingproteins and steroidogenesis. Steroid receptors represent one of the best characterized transcription factors so that the book will be of general interest to Molecular Biologists studying eucaryotic gene regulation. Chapters on the mechanisms of action of steoid antagonists and defective receptorsin target cells will be of particular interest to Endocrinologists and Clinicians. In such a rapidly progressing field it is difficult to keep up with all the literature but this book, written by international experts, focuses on the most important advances that have been made recently.