From Dna To Diversity

In this landmark work, the author team led by Dr. Sean Carroll presents the general principles of the genetic basis of morphological change through a synthesis of evolutionary biology with genetics and embryology. In this extensively revised second edition, the authors delve into the latest discoveries, incorporating new coverage of comparative genomics, molecular evolution of regulatory proteins and elements, and microevolution of animal development. An accessible text, focusing on the most well-known genes, developmental processes and taxa. Builds logically from developmental genetics and regulatory mechanisms to evolution at different genetic morphological levels. Adds major insights from recent genome studies, new evo-devo biology research findings, and a new chapter on models of variation and divergence among closely related species. Provides in-depth focus on key concepts through well-developed case studies. Features clear, 4-color illustrations and photographs, chapter summaries, references and a glossary. Presents the research of Dr. Carroll, a pioneer in the field and the past president of the Society for Developmental Biology.

From DNA to Diversity represents the definitive synthesis of the new material on developmental genetics and evolutionary biology. Written by the most respected, author team, this text will be the monumental work for shaping the field.

A geneticist discusses the role of DNA in the evolution of life on Earth, explaining how an analysis of DNA reveals a complete record of the events that have shaped each species and how it provides evidence of the validity of the theory of evolution.

Information is central to the evolution of biological complexity, a physical system relying on a continuous supply of energy. Biology provides superb examples of the consequent Darwinian selection of mechanisms for efficient energy utilisation. Genetic information, underpinned by the Watson-Crick base-pairing rules is largely encoded by DNA, a molecule uniquely adapted to its roles in information storage and utilisation.This volume addresses two fundamental questions. Firstly, what properties of the molecule have enabled it to become the predominant genetic material in the biological world today and secondly, to what extent have the informational properties of the molecule contributed to the expansion of biological diversity and the stability of ecosystems. The author argues that bringing these two seemingly unrelated topics together enables Schrödinger's What is Life?, published before the structure of DNA was known, to be revisited and his ideas examined in the context of our current biological understanding.

Consumer genomics, encompassing both direct-to-consumer applications (i.e., genetic testing that is accessed by a consumer directly from a commercial company apart from a health care provider) and consumer-driven genetic testing (i.e., genetic testing ordered by a health care provider in response to an informed patient request), has evolved considerably over the past decade, moving from more personal utility-focused applications outside of traditional health care to interfacing with clinical care in nontraditional ways. As consumer genomics has increasingly intersected with clinical applications, discussions have arisen around the need to demonstrate clinical and analytical validity and clinical utility due to the potential for misinterpretation by consumers. Clinical readiness and interest for this information have presented educational and training challenges for providers. At the same time, consumer genomics has emerged as a potentially innovative mechanism for thinking about health literacy and engaging participants in their health and health care. To explore the current landscape of consumer genomics and the implications for how genetic test information is used or may be used in research and clinical care, the Roundtable on Genomics and Precision Health of the National Academies of Sciences, Engineering, and Medicine hosted a public workshop on October 29, 2019, in Washington, DC. Discussions included such topics as the diversity of participant populations, the impact of consumer genomics on health literacy and engagement, knowledge gaps related to the use of consumer genomics in clinical care, and regulatory and health policy issues such as data privacy and security. A broad array of stakeholders took part in the workshop, including genomics and consumer genomics experts, epidemiologists, health disparities researchers, clinicians, users of consumer genomics research applications, representatives from patient advocacy groups, payers, bioethicists, regulators, and policy makers. This publication summarizes the presentations and discussion of the workshop.

Biology has entered an era in which interdisciplinary cooperation is at an all-time high, practical applications follow basic discoveries more quickly than ever before, and new technologiesâ€"recombinant DNA, scanning tunneling microscopes, and moreâ€"are revolutionizing the way science is conducted. The potential for scientific breakthroughs with significant implications for society has never been greater. Opportunities in Biology reports on the state of the new biology, taking a detailed look at the disciplines of biology; examining the advances made in medicine, agriculture, and other fields; and pointing out promising research opportunities. Authored by an expert panel representing a variety of viewpoints, this volume also offers recommendations on how to meet the infrastructure needsâ€"for funding, effective information systems, and other supportâ€"of future biology research. Exploring what has been accomplished and what is on the horizon, Opportunities in Biology is an indispensable resource for students, teachers, and researchers in all subdisciplines of biology as well as for research administrators and those in funding agencies.

THE INSTANT NEW YORK TIMES AND WALL STREET JOURNAL BESTSELLER The capstone book in a trilogy from the New York Times bestselling author of How to Lead and The American Story and host of Bloomberg TV’s The David Rubenstein Show—American icons and historians on the ever-evolving American experiment, featuring Ken Burns, Madeleine Albright, Wynton Marsalis, Billie Jean King, Henry Louis Gates Jr., and many more. In this lively collection of conversations—the third in a series from David Rubenstein—some of our nations’ greatest minds explore the inspiring story of America as a grand experiment in democracy, culture, innovation, and ideas. -Jill Lepore on the promise of America -Madeleine Albright on the American immigrant -Ken Burns on war -Henry Louis Gates Jr. on reconstruction -Elaine Weiss on suffrage -John Meacham on civil rights -Walter Isaacson on innovation -David McCullough on the Wright Brothers -John Barry on pandemics and public health -Wynton Marsalis on music -Billie Jean King on sports -Rita Moreno on film Exploring the diverse make-up of our country’s DNA through interviews with Pulitzer Prize–winning historians, diplomats, music legends, and sports giants, The American Experiment captures the dynamic arc of a young country reinventing itself in real-time. Through these enlightening conversations, the American spirit comes alive, revealing the setbacks, suffering, invention, ingenuity, and social movements that continue to shape our vision of what America is—and what it can be.