Gallstones

This book looks at the comprehensive management of all aspects of gallstone disease, from the epidemiology and pathogenesis to the complex management approaches required for some patients. The main emphasis is placed on effective diagnosis and treatment, making extensive use of practical case-based material while reviewing the guidelines in a multi-disciplinary manner. It is an essential read for all clinicians involved in managing patients with gallstone disease.

Many people suffer from gallstones and undergo unnecessary surgery. Reading this book will help you to understand natural ways of ridding your gallstones without necessarily resorting to surgery. This book takes you step-by-step through a natural method of flushing your gallstones without pain in just 24 hours. Learn what gallstones are made of, how toxins can affect them, how to detoxify the body in preparation for the gallstone flush, what supplements to use and how thousands of people have been cured of gallstones naturally without surgery. Dr Georgiou has personally supervised more than 5,000 gallstone flushes throughout his career as a Holistic practitioner.

Textbook of Surgery is a core book for medical and surgicalstudents providing a comprehensive overview of general andspeciality surgery. Each topic is written by an expert in thefield. The book focuses on the principles and techniques of surgicalmanagement of common diseases. Great emphasis is placed onproblem-solving to guide students and junior doctors through theirsurgical training. Throughout the book are numerous reproducible line drawings,tables and boxes that will prove invaluable for learning andrevision. In addition there are detailed guidelines provided forsurgical management. Up-to-date and ideal for medical students and junior doctors onsurgical attachments and a perfect refresher for RACS and MRCScandidates. Reviews of the last edition “The textbook presents a compact and contemporary overviewand is not so much a reference book as a working tome suitable forfamiliarization with current trends in treatment and diagnosis inthese various areas. …found this textbook very informative and a pleasure toread.” ANZ Journal of Surgery Vol. 72, No. 12.

This book, the proceedings of the Falk Syposium No. 139 on "Gallstones: Pathogenesis and Treatment", held in Freiburg, Germany, on January 15-16, 2004, reflects the tremendous advances in the field of biliary diseases both at the genetic and cellular as well as the clinical levels. In industrialized countries, gallstones are a frequent clinical entity with a prevalence of 10-15%. In clinical practice one can differentiate between cholesterol stones, black pigment stones and brown pigment stones. 80-90% of gallbladder stones are cholesterol stones, 10--20% are black pigment stones. The prevalence of cholesterol stones increases with age and in Europe in the 70+ age group reaches about 20% in males and about 30% in females. Gallstones and gallstone diseases, therefore, are a frequent and important clinical problem. The book addresses the basic aspects of gallstone pathogenesis as well as the non-surgical and surgical treatment of gallstone diseases. Of particular interest are the epidemiology and genetics of gallstone formation, with definition of risk factors, in particular of genetic predispositions. Other major aspects are the hepatocellular and bilary transport mechanisms that predispose to the formation of gallstones. Apart from cholesterol and lipid transport and absorption, gallbladder function plays a central role in gallstone formation. Another clinically very relevant topic is the treatment of gallstone diseases by drugs, endoscopic and other non-surgical interventions, and surgery, as well as the long-term outcome of therapeutic interventions. The volume concludes with a state-of-the-art chapter on "Gallstone Research in the Post-Genomic Era". Gallstones: Pathogenesis and Treatment is an excellent update on the pathogenesis of gallstones as well as on the treatment of gallstone diseases, written by an international faculty of outstanding clinicans and scientists. The book will, therefore, be of great interest to hepatologists and gastroenterologists in academic institutions as well as in clinical practice.

Gallstone disease is one of the most prevalent digestive diseases, resulting in a considerable amount of financial and social burden in the USA. Approximately 20 million Americans have gallstones. Because gallstone disease is a common clinical problem, basic and clinical studies on this disease continue to advance at a rapid pace, and a book focusing on basic science, current diagnosis and management of gallstones will greatly help practicing gastroenterologists, gastroenterological endoscopists, physicians and surgeons to understand the etiology of this disease and the availability of effective medical therapies. In this book, recognised medical experts discuss recent advances in the epidemiology, pathophysiology, pathogenesis, genetics and diagnosis, as well as endoscopic, medical and surgical therapies of gallstone disease. This compilation on gallstone disease was written by fifty authors from eight countries (Canada, China, Germany, Italy, Japan, the Netherlands, the United Kingdom, and the USA). There are thirty chapters in this book. Chapters One and Two discuss the epidemiology and natural history of cholesterol and pigment gallstone disease. Chapters Three through Six summarise recent progress in the pathogenesis of gallstone disease from a physical-chemical and pathophysiological perspective. Chapter Seven elucidates the roles of the immune system and the microbiome on the pathogenesis of cholesterol gallstones. Chapters Eight and Nine review the roles of nuclear receptors and the enterohepatic circulation of bile acids in cholesterol gallstone diseases. Chapters Ten through Twelve discuss the discovery of Lith genes and more fundamental knowledge concerning the genetic determinants and the molecular mechanisms underlying the critical role of Lith genes in gallstone formation in mice and humans. Chapter Thirteen discusses gallstones in pregnancy and explains why gallstone prevalence is higher in women than in men. Chapters Fourteen through Eighteen discuss the effects of diet, insulin resistance, obesity, diabetes, and nonalcoholic fatty liver disease on the formation of cholesterol gallstones. Chapter Nineteen provides diagnostic flow charts for biliary lithiasis. In Chapter Twenty, important non-invasive imaging findings of common gallbladder pathology are reviewed, and current strategies for the optimal use of imaging in the evaluation of patients with suspected gallbladder disease is discussed. Chapter Twenty-One evaluates current pharmacological therapy in cholesterol gallstones. Chapter Twenty-Two describes laparoscopic cholecystectomy. Chapters Twenty-Three through Twenty-Six discuss surgical treatment and endoscopic management of common bile duct stones and hepatolithiasis. Chapter Twenty-Seven reviews recent progress on the endoscopic treatment of bile duct stones with endoscopic papillary large balloon dilation. Chapter Twenty-Eight addresses surgical treatment of gallstones and their complications. Chapter Twenty-Nine discusses treatment of intrahepatic duct stones from a Western perspective. Chapter Thirty describes the history and incidence rate of Mirizzi syndrome, and summarises recent progress in its classification, diagnosis, and management. The articles in this book provide a state-of-the-art review of the current knowledge on the lithogenesis and the management of gallstone disease, as well as promote future epidemiological investigation, basic and translational research, and clinical studies on this prevalent biliary disorder worldwide.

The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism.

Gallstone Formation, Diagnosis, Treatment, and Prevention describes the current scenario of gallstones and adopted treatment methods. It is a complete reference for researchers introducing new techniques to help prevent extreme treatments such as a cholecystectomy. This reference provides current knowledge and basic challenges of understanding gallstone formation, with all variations of composition including complications of the treatment process. This content directs researchers to focus on gallstone mechanisms to design and develop new treatment methods. The book provides all possible factors for gallstone formation as well as preventative measures. Offers treatment methods, including both chemical and herbal methods Presents mechanisms behind gallstone formation that are important to researchers to determine treatment methods that can prevent cholecystectomy Includes the latest research on acute pancreatitis, one of the major concerns of gastrointestinal disease Discusses the effects of gallstone as a cancer-causing mechanism