Gene Structure And Expression

This third edition of a successful textbook is a concise description of the structure and function of genes.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Features contributions from luminaries in the field of genetics. Articles include examinations of the structure of nucleosomes and chromatin, hormonal regulation of gene expression, assembly of mitochondrial proteins, and the non-universality of the genetic code.

Emphasizing exciting recent developments in the study of gene structure and transcription processes, this compares and contrasts euykaryotic and prokaryotic gene structure, transcription apparatus and regulation of transcription at molecular level.

A detailed knowledge of the mechanisms underlying the transcriptional control of gene expression is of fundamental importance to many areas of contemporary biomedical research, ranging from understanding basic issues (such as control of embryonic development) to practical applications in industry and medicine. Although elementary concepts of gene expression are described in all general molecular biology textbooks, the depth of coverage is often rather limited and recent discoveries are sometimes not adequately taken into consideration. This book presents much of the current thinking concerning molecular mechanisms of transcriptional control in a form easily accessible to undergraduates with an understanding of basic molecular biology concepts. It contains detailed information about the various pro- and eukaryotic transcriptional machineries that has recently become available through the combined efforts of geneticists, biochemists and structural biologists. The book will thus not only serve as an undergraduate text but also offer something new and interesting to more advanced readers and professional scientists who want to keep up to date with rapid advances in this field. Contents:RNA PolymerasesBasal Factors Recognize Promoters and Assemble the Pre-Initiation Transcription ComplexesGene-Specific Transcription FactorsCoactivators: Interface between Gene-Specific and Basal Transcription FactorsControl of RNA Elongation and TerminationRNAPI and RNAPIII Transcriptional MachineriesChromatinNuclear Matrix, Chromosome Scaffolds and Transcriptional FactoriesGene Expression Dynamics and Global Genome Transcription PatternsAppearing on the Horizon: Medical Applications Focusing on Transcriptional Control Mechanisms Readership: Undergraduate and graduate students in molecular biology, biochemistry and genetics. Keywords:Gene Expression;Genetics;Mechanisms;Basal Transcriptional Machinery

The recent surge of interest in recombinant DNA research is understandable considering that biologists from all disciplines, using recently developed mo lecular techniques, can now study with great precision the structure and regulation of specific genes. As a discipline, molecular biology is no longer a mere subspeciality of biology or biochemistry: it is the new biology. Current approaches to the outstanding problems in virtually all the traditional disci plines in biology are now being explored using the recombinant DNA tech nology. In this atmosphere of rapid progress, the role of information exchange and swift publication becomes quite crucial. Consequently, there has been an equally rapid proliferation of symposia volumes and review articles, apart from the explosion in popular science magazines and news media, which are always ready to simplify and sensationalize the implications of recent dis coveries, often before the scientific community has had the opportunity to fully scrutinize the developments. Since many of the recent findings in this field have practical implications, quite often the symposia in molecular biology are sponsored by private industry and are of specialized interest and in any case quite expensive for students to participate in. Given that George Wash ington University is a teaching institution, our aim in sponsoring these Annual Spring Symposia is to provide, at cost, a forum for students and experts to discuss the latest developments in selected areas of great significance in biology. Additionally, since the University is located in Washington, D. C.