Genetic Crossroads

The Middle East plays a major role in the history of genetic science. Early in the twentieth century, technological breakthroughs in human genetics coincided with the birth of modern Middle Eastern nation-states, who proclaimed that the region's ancient history—as a cradle of civilizations and crossroads of humankind—was preserved in the bones and blood of their citizens. Using letters and publications from the 1920s to the present, Elise K. Burton follows the field expeditions and hospital surveys that scrutinized the bodies of tribal nomads and religious minorities. These studies, geneticists claim, not only detect the living descendants of biblical civilizations but also reveal the deeper past of human evolution. Genetic Crossroads is an unprecedented history of human genetics in the Middle East, from its roots in colonial anthropology and medicine to recent genome sequencing projects. It illuminates how scientists from Turkey to Yemen, Egypt to Iran, transformed genetic data into territorial claims and national origin myths. Burton shows why such nationalist appropriations of genetics are not local or temporary aberrations, but rather the enduring foundations of international scientific interest in Middle Eastern populations to this day.

Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers thorough discussions on preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Chapter contributions from leading bioethicists and clinicians encourage a global, holistic perspective on applied challenges and the moral questions relating the implementation of genetic reproductive technology. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors and graduate and medical students. As the Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy, this book presents a timely resource. Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive genetics Contains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology Discusses preconception carrier screening, genetic engineering and the use of CRISPR gene editing, mitochondrial gene replacement therapy, ethical issues, and more

'Crossing Over' promotes reflection on the socio-ethical, and policy and regulatory aspects of genomics and biotechnology. This collection of essays illuminates the common themes surrounding this hotly contested issue and considers the politics, public perception, ethics, media representations and future possibilities of genomics.

Epigenetics is currently one of the fastest-growing fields in the sciences. Epigenetic information not only controls DNA expression but links genetic factors with the environmental experiences that influence the traits and characteristics of an individual. What we eat, where we work, and how we live affects not only the activity of our genes but that of our offspring as well. This discovery has imposed a revolutionary theoretical shift on modern biology, especially on evolutionary theory. It has helped to uncover the developmental processes leading to cancer, obesity, schizophrenia, alcoholism, and aging, and to facilitate associated medial applications such as stem cell therapy and cloning. Above the Gene, Beyond Biology explores how biologists in this booming field investigate and explain living systems. Jan Baedke offers the first comprehensive philosophical discussion of epigenetic concepts, explanations, and methodologies so that we can better understand this “epigenetic turn” in the life sciences from a philosophical perspective.

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

AN INSTANT NEW YORK TIMES BESTSELLER! From celebrated anthropologist Jennifer Raff comes the untold story—and fascinating mystery—of how humans migrated to the Americas. ORIGIN is the story of who the first peoples in the Americas were, how and why they made the crossing, how they dispersed south, and how they lived based on a new and powerful kind of evidence: their complete genomes. ORIGIN provides an overview of these new histories throughout North and South America, and a glimpse into how the tools of genetics reveal details about human history and evolution. 20,000 years ago, people crossed a great land bridge from Siberia into Western Alaska and then dispersed southward into what is now called the Americas. Until we venture out to other worlds, this remains the last time our species has populated an entirely new place, and this event has been a subject of deep fascination and controversy. No written records—and scant archaeological evidence—exist to tell us what happened or how it took place. Many different models have been proposed to explain how the Americas were peopled and what happened in the thousands of years that followed. A study of both past and present, ORIGIN explores how genetics is currently being used to construct narratives that profoundly impact Indigenous peoples of the Americas. It serves as a primer for anyone interested in how genetics has become entangled with identity in the way that society addresses the question "Who is indigenous?"

The Human Genome Project has triggered a technological revolution that has influenced nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, prenatal genetic testing, and gene therapy. This second edition of Clinical Ethics at the Crossroads of Genetic and Reproductive Technologies offers a thorough, timely discussion of ethical issues raised by the latest genetic and genomic technologies applied in human reproductive and prenatal medicine, providing practical recommendations, guidelines, and algorithms to support ethical clinical practice. Here, international experts consider the ethics of technologies from preconception carrier screening to genetic engineering, CRISPR gene editing, mitochondrial gene replacement therapy, sex selection, predictive testing, secondary findings, embryo reduction, and the moral status of the embryo, genetic enhancement, and the sharing of genetic data. Throughout the book, contributors adopt a global, holistic perspective on applied challenges and the moral questions around the implementation of genetic reproductive technologies. The book is an ideal resource for practitioners, regulators, lawmakers, clinical researchers, genetic counselors, and graduate and medical students.This fully updated second edition examines new developments in the field, tackling ethical aspects of organoid development, recent advances in pharmacogenomics, direct-to-consumer genetic testing, and genetic engineering. • Provides practical analysis of the ethical issues raised by cutting-edge techniques and recent advances in prenatal and reproductive geneticsContains contributions from leading bioethicists and clinicians who offer a global, holistic perspective on applied challenges and moral questions relating to genetic and genomic reproductive technology • Discusses preconception carrier screening, genetic engineering, and the use of CRISPR gene editing, mitochondrial gene replacement therapy, and ethical issues, among others • Considers ethical aspects of recent advances and new technologies in the field, from organoid development to pharmacogenomics and direct-to-consumer genetic testing

A unique narrative structure brings the history of race science in mid-twentieth-century India to vivid life. There has been a recent explosion in studies of race science in the twentieth and twenty-first centuries, but most have focused either on Europe or on North America and Australia. In this stirring history, Projit Bihari Mukharji illustrates how India appropriated and repurposed race science to its own ends and argues that these appropriations need to be understood within the national and regional contexts of postcolonial nation-making—not merely as footnotes to a Western history of “normal science.” The book comprises seven factual chapters operating at distinct levels—conceptual, practical, and cosmological—and eight fictive interchapters, a series of epistolary exchanges between the Bengali author Hemendrakumar Ray (1888–1963) and the protagonist of his dystopian science fiction novel about race, race science, racial improvement, and dehumanization. In this way, Mukharji fills out the historical moment in which the factual narrative unfolded, vividly revealing its moral, affective, political, and intellectual fissures.