Getting It Right In Science And Medicine

This book advocates the importance and value of errors for the progress of scientific research! Hans Kricheldorf explains that most of the great scientific achievements are based on an iterative process (an ‘innate self-healing mechanism’): errors are committed, being checked over and over again, through which finally new findings and knowledge can arise. New ideas are often first confronted with refusal. This is so not only in real life, but also in scientific and medical research. The author outlines in this book how great ideas had to ripen over time before winning recognition and being accepted. The book showcases in an entertaining way, but without schadenfreude, that even some of the most famous discoverers may appear in completely different light, when regarding errors they have committed in their work. This book is divided into two parts. The first part creates a fundament for the discussion and understanding by introducing important concepts, terms and definitions, such as (natural) sciences and scientific research, laws of nature, paradigm shift, and progress (in science). It compares natural sciences with other scientific disciplines, such as historical research or sociology, and examines the question if scientific research can generate knowledge of permanent validity. The second part contains a collection of famous fallacies and errors from medicine, biology, chemistry, physics and geology, and how they were corrected. Readers will be astonished and intrigued what meanders had to be explored in some cases before scientists realized facts, which are today’s standard and state-of-the-art of science and technology. This is an entertaining and amusing, but also highly informative book not only for scientists and specialists, but for everybody interested in science, research, their progress, and their history!

Presents evidence from medical journals that beliefs, thoughts, and feelings can cure the body and shows readers how to apply this knowledge in their own lives. -- provided by publisher.

A Nobel Prize–winning cancer biologist, leader of major scientific institutions, and scientific adviser to President Obama reflects on his remarkable career. A PhD candidate in English literature at Harvard University, Harold Varmus discovered he was drawn instead to medicine and eventually found himself at the forefront of cancer research at the University of California, San Francisco. In this “timely memoir of a remarkable career” (American Scientist), Varmus considers a life’s work that thus far includes not only the groundbreaking research that won him a Nobel Prize but also six years as the director of the National Institutes of Health; his current position as the president of the Memorial Sloan-Kettering Cancer Center; and his important, continuing work as scientific adviser to President Obama. From this truly unique perspective, Varmus shares his experiences from the trenches of politicized battlegrounds ranging from budget fights to stem cell research, global health to science publishing.

As more and more people survive into old age, the burden of caring for them becomes greater and greater. Although it is now possible to alleviate many of the afflictions that beset mankind, no society can afford to pay for all the healthcare that is now available or technically possible. People working in healthcare increasingly have to do more with less. Rationing takes many forms, mostly covert, and the less privileged in most societies end up struggling to get their proper share of the available healthcare resources. All too often, those in the front-line have to deal with the consequences of this 'rationing by default': healthcare professionals find themselves rushed off their feet simply doing the basic tasks and completing all the paperwork; placing frail, sick people in ever lengthening queues, sometimes asking them to wait for hours in the middle of the night under uncomfortable and even unsafe conditions; and, worst of all, working under conditions they would rather avoid in which the safety margin for those they are caring for has been greatly diminished. We are all aware that under these conditions the chance of making a mistake which can seriously harm or even lead to the death of a patient is greatly increased. But what can be done about this? How can you be sure that you are doing the right thing when faced with having to practise an uncertain science on vulnerable patients in a complex system under ever-changing conditions? At what point could you cross the invisible line from reasonable to irresponsible or unethical behaviour by tolerating conditions or tacitly accepting practices which may be regarded as unacceptable, even though you may have little immediate control over them? This book is a guide to getting it right for healthcare professionals. It is about doing the right thing, in the right way, at the right time, for the right people. These are the dimensions of quality in healthcare, and although some are in conflict (equitable access and efficiency, for example), adherence to ethical practice and professional behaviour will help lead healthcare practitioners through the minefield of responsibilities and priorities. Real-life situations are integral to the book, with over 500 clinical examples referred to within the text.

The next time you get sick, consider this before picking up the aspirin: your body may be doing exactly what it's supposed to. In this ground-breaking book, two pioneers of the science of Darwinian medicine argue that illness as well as the factors that predispose us toward it are subject to the same laws of natural selection that otherwise make our bodies such miracles of design. Among the concerns they raise: When may a fever be beneficial? Why do pregnant women get morning sickness? How do certain viruses "manipulate" their hosts into infecting others? What evolutionary factors may be responsible for depression and panic disorder? Deftly summarizing research on disorders ranging from allergies to Alzheimer's, and form cancer to Huntington's chorea, Why We Get Sick, answers these questions and more. The result is a book that will revolutionize our attitudes toward illness and will intrigue and instruct lay person and medical practitioners alike.

Doing the Right Thing: Ethics in Science by the Editors of Scientific American Most of us have probably had those discussions, either in a classroom setting or otherwise, where a hypothetical situation is given and you're asked to choose between two or more unsatisfying options. If you follow option A, five people die; if you follow option B, one person dies. What do you do? Option B looks like the lesser of the evils, but then there's a wrinkle. Option B requires you to actively murder the one person to save five. Now what do you do? Making ethical decisions involves more than listening to an inner moral compass, a feeling in the gut of what's right and wrong; and questions of ethics in science are becoming increasingly complex, especially as technology encroaches upon even our most private cellular spaces. In this eBook, Doing the Right Thing: Ethics in Science, we cover a wide range of areas in science and medicine where complicated ethical questions come to bear, beginning with the first section, "Genomics." In "Are Personal Genome Scans Medically Useless," Sally Lehrman examines the value, or lack thereof, in the information obtained from direct-to-consumer genotyping tests, a field that exploded in the '00s. The middle sections are devoted to ethics in research, where informed—and ethically sound—choices are the basis of many scientific studies. Sections 2, 3 and 4 analyze the challenges unique to three areas, respectively: medical, pharmaceutical and basic research. Medical studies often reveal more information than researchers are looking for, and two articles, "The Ethics of Scan and Tell" and "Reporting Unrelated Findings in Study Subjects," examine questions of responsibility toward study subjects. Later, Charles Seife ferrets out doctors' financial ties to pharmaceutical companies in "Is Drug Research Trustworthy?" and Katherine Harmon calculates "The Cost of Misconduct" to the taxpayer. Finally Section 6, "Ethics and the Mind," analyzes the process of how we resolve moral conflicts when we make decisions. The interaction between reasoning and emotion is poorly understood, as seen in both "Anguish and Ethics" and "When Morality Is Hard to Like," but studies show that the emotional and memory regions of the brain are more active when confronted with difficult moral questions. These decisions are usually made after great inner struggle – think again of option B. What would you do?

Essential, required reading for doctors and patients alike: A Pulitzer Prize-winning author and one of the world’s premiere cancer researchers reveals an urgent philosophy on the little-known principles that govern medicine—and how understanding these principles can empower us all. Over a decade ago, when Siddhartha Mukherjee was a young, exhausted, and isolated medical resident, he discovered a book that would forever change the way he understood the medical profession. The book, The Youngest Science, forced Dr. Mukherjee to ask himself an urgent, fundamental question: Is medicine a “science”? Sciences must have laws—statements of truth based on repeated experiments that describe some universal attribute of nature. But does medicine have laws like other sciences? Dr. Mukherjee has spent his career pondering this question—a question that would ultimately produce some of most serious thinking he would do around the tenets of his discipline—culminating in The Laws of Medicine. In this important treatise, he investigates the most perplexing and illuminating cases of his career that ultimately led him to identify the three key principles that govern medicine. Brimming with fascinating historical details and modern medical wonders, this important book is a fascinating glimpse into the struggles and Eureka! moments that people outside of the medical profession rarely see. Written with Dr. Mukherjee’s signature eloquence and passionate prose, The Laws of Medicine is a critical read, not just for those in the medical profession, but for everyone who is moved to better understand how their health and well-being is being treated. Ultimately, this book lays the groundwork for a new way of understanding medicine, now and into the future.

Getting the right diagnosis is a key aspect of health care - it provides an explanation of a patient's health problem and informs subsequent health care decisions. The diagnostic process is a complex, collaborative activity that involves clinical reasoning and information gathering to determine a patient's health problem. According to Improving Diagnosis in Health Care, diagnostic errors-inaccurate or delayed diagnoses-persist throughout all settings of care and continue to harm an unacceptable number of patients. It is likely that most people will experience at least one diagnostic error in their lifetime, sometimes with devastating consequences. Diagnostic errors may cause harm to patients by preventing or delaying appropriate treatment, providing unnecessary or harmful treatment, or resulting in psychological or financial repercussions. The committee concluded that improving the diagnostic process is not only possible, but also represents a moral, professional, and public health imperative. Improving Diagnosis in Health Care, a continuation of the landmark Institute of Medicine reports To Err Is Human (2000) and Crossing the Quality Chasm (2001), finds that diagnosis-and, in particular, the occurrence of diagnostic errorsâ€"has been largely unappreciated in efforts to improve the quality and safety of health care. Without a dedicated focus on improving diagnosis, diagnostic errors will likely worsen as the delivery of health care and the diagnostic process continue to increase in complexity. Just as the diagnostic process is a collaborative activity, improving diagnosis will require collaboration and a widespread commitment to change among health care professionals, health care organizations, patients and their families, researchers, and policy makers. The recommendations of Improving Diagnosis in Health Care contribute to the growing momentum for change in this crucial area of health care quality and safety.