Glioblastoma Part Ii Molecular Targets And Clinical Trials An Issue Of Neurosurgery Clinics Of North America

This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include—but are not limited to—Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts on management of high grade glioma. Some of the articles in this issue include: Use of language mapping to aid resection of eloquent gliomas; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Nanotechnology potential applications for GBM therapy; High Grade Gliomas in children; Modern Advances in Brain Tumor Treatments; Molecular pathways of Avastin interactions for the treatment of glioblastoma; and Quality of Life and Outcomes in Glioblastoma management.

This issue of Neurosurgery Clinics, guest edited by Dr. Michael A. Vogelbaum, is devoted to Glioblastoma, Part I: Surgical Management and Adjuncts. This is one of four issues selected each year by the series Consulting Editors, Russell R. Lonser and Daniel K. Resnick. Articles in this issue include: Perioperative Management of Patients with Glioblastoma, Role of Resection in Glioblastoma Management, Advancing Imaging to Enhance Surgery, Intraoperative Imaging for High-Grade Glioma Surgery, Use of Intraoperative Fluorophores, Extent of Resection of Glioblastoma, Functional Mapping for Glioma Surgery: Preoperative Mapping Tools, Functional Mapping for Glioma Surgery: Intraoperative Mapping Tools, Surgical Adjuncts for Glioblastoma, Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors, Stereotactic Laser Ablation of Glioblastoma, Radiosurgery for Glioblastoma, Challenges Associated with Reoperation in Patients with Glioma, and Surgery for Glioblastoma in Elderly Patients.

This issue of Neurosurgery Clinics, guest edited by Drs. Guy McKhann and Hugues Duffau, with consulting editors Russell R. Lonser and Daniel K. Resnick, will focus on Low-Grade Glioma. Topics includes, but are not limited to, Epidemiology and Molecular Epidemiology; WHO Pathological and Molecular Classification; Molecular Pathogenesis; Glioma Cell Migration and Heterogeneity; Clinical Presentation, Natural History, and Prognosis; LGG Epilepsy; MRI, fMRI, DTI, Molecular Imaging; Brain Mapping Techniques in LGG; Surgical Adjuncts to Increase EOR iMRI, Flourescence, Raman Histology; Mapping Cognition and Emotion; Extent of Resection; EOR vs Molecular Classification; Chemotherapy Treatment and Trials; Radiotherapy Treatment and Trials; Higher Order Surgical Questions; and Building a Glioma Practice.

Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.

In this issue of Neurosurgery Clinics, Guest Editor James A. Stadler brings his considerable expertise to the topic of syndromic neurosurgery. Top experts in the field cover key topics such as Syndromic epilepsy, tumor syndromes, syndromic craniosynostosis, and more. Provides in-depth, clinical reviews on syndromic neurosurgery, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains 14 relevant, practice-oriented topics including The history of syndromic neurosurgery; Multidisciplinary evaluation of neurosurgical patients with genetic syndromes; Neurosurgical evaluation and management of children with achondroplasia; Neurosurgical evaluation and management of patients with connective tissue disorders; and more.

This issue of Neurosurgery Clinics, guest edited by Dr. Domagoj Coric, provides an Update on Motion Preservation Technologies. This issue is one of four selected each year by our series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. This issue discusses state-of-the-art indications, technique, devices, complications and evidence basis for motion preserving technologies in the cervical and lumbar spines. Topics covered in this issue will include: Cervical Total Disc Replacement: Indications and Technique, Cervical Total Disc Replacement: Off-label and Expanded Indications, Cervical Total Disc Replacement: FDA-approved Devices, Cervical Total Disc Replacement: Novel Devices, Cervical Spine Surgery: Arthroplasty versus Fusion versus Posterior Foraminotomy, Cervical Total Disc Replacement: Complications and Complication Avoidance, Cervical Total Disc Replacement: Long-term Outcomes, Biomechanics of Cervical Arthroplasty Devices, Adjacent-level Disease following Spinal Arthroplasty, Lumbar Total Disc Replacement: Current Usage, and Posterior Lumbar Facet Replacement and Arthroplasty.

Standard therapy for high grade glioma is a topic that is evolving, timely, and relevant. Guest Editors Isaac Yang, MD and Seunggu Han, MD have assembled a group of experts to highlight the latest updates on various forms of management of high grade glioma. Some of the articles included in this issue focus on Extent of Resection for Glioblastoma; Role of adjuvant radiation therapy; Survival benefit of the Temozolomide protocol; Alternative chemotherapeutic agents; The role of avastin; Radiology; Pseuodprogression and Treatment effect; Pathology; Medical Management; Management of insular gliomas; Use of motor mapping; GBM treatment with clinical trials for surgical resection; Clinical trials with immunotherapy; Clinical trials for small molecule inhibitors; Future role of CED for GBM treatment; Application of a vault nanoparticle therapy for GBM therapy; Management of high grade gliomas in pediatric populations; Targeting Glioma Stem Like Cells with a focus on CD 133; and Potential Role for STAT3 inhibitors in glioblastoma.