Handbook Of Cardiovascular Research

Cardiovascular disease refers to the class of diseases that involve the heart of blood vessel. Most countries face high and increasing rates of cardiovascular disease. Each year, heart disease kills more Americans than cancer. It is the number one cause of death and disability in the U.S. and most European countries. The causes, prevention and/or treatment of all forms of cardiovascular disease are active fields of biomedical research. This book presents current research from around the world in this field.

Cardiovascular disease remains the major cause of morbidity and mortality throughout developed countries and is also rapidly increasing in developing countries. Cardiovascular medicine and the specialty of cardiology continue to expand, and the remit of the cardiologist is forever broader with the development of new sub-specialties. The Oxford Handbook of Cardiology provides a comprehensive but concise guide to all modern cardiological practice with an emphasis on practical clinical management in many different contexts. This second edition addresses all the key advances made in the field since the previous edition, including interventional cardiology, electrophysiology, and pharmacology. It expands the remit to medical students and the more junior doctor while retaining the level of detail required by more senior practitioners within the field.

This book is a practical and up-to-date review that discusses the impact of traditional cardiovascular risk factors in patients with rheumatoid arthritis, the effect of rheumatoid arthritis disease activity and severity on cardiovascular comorbidity, and the influence of rheumatoid arthritis drug therapy on cardiovascular risk. This title also explores cardiovascular disease as a manifestation of rheumatoid arthritis and highlights the available methods for screening and diagnosing these conditions. Current and emerging therapies to aid clinicians in the daily management of their patients are also featured in this title. Busy healthcare professionals who are looking for a collaborative approach to these conditions will benefit from this comprehensive overview.

While some research methods or techniques are applicable in several areas of medicine, research in cardiovascular diseases requires knowledge of an increasing array of procedures, techniques and measurements that are highly specialized and unique to this area of investigation. Edited by senior clinical investigators who are recognized leaders in cardiovascular medicine worldwide, this book provides readers with a comprehensive, practical “how-to-do-it” review of best-practice techniques for cardiovascular research.

Autopsy derives from the greek word autopsia, which means act of seeing with one’s own eyes. It remains the most objective and accurate method to understand human. disease. Unfortunately, the volume of autopsies in teaching hospitals has decreased dramatically over the past years. The crucial factors that account for this are the recent progress and development of new technologies, especially in diagnostic imaging, immunology, cell biology and genetics. Additionally, the perpetual fear of legal liability by physicians accounts for its further decline. Consequently, physicians and medical students are engaged in fewer autopsies and are not reaping the rich educational rewards that accompany these examinations. The purpose of the autopsy is not only to establish the cause of death, but also to determine the nature and course of the disease process. Our goal with this book is to emphasize the importance of the post-mortem exam and the correlation between pathologic material and clinical data by analyzing actual cases with problem-based methodology. The focus of this handbook is on cardiovascular disease, and when appropriate, other disease categories are included if they have an impact on cardiovascular function. The approach is more than the usual clinico-pathological correlation. Rather, we attempt to present the material from the perspective of the autopsy table. We use the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition.

This book fulfils the need to keep up with the high number of innovations in proteomics, and at the same time to warn the readers about the danger of manufacturers and scientists claims around new technologies. Mass spectrometry stands as the core technology in proteomics. The emerging field of targeted proteomics and its potential applications in the cardiovascular arena are also reviewed and discussed. A concluding section highilghts the promise of proteomics in the light of these recent developments.​ As this technique and its applications have undergone remarkable advances in the past years, recent updates on proteomic applications are covered. Another key concept revealed by proteomic technologies is that the extent of protein post-translational modifications (PTMs) as well as their impact on the phenotype has been underestimated by pre-proteomics science. As such, part of the manual focuses on the emerging role of PTMs in basic cardiovascular sciences and in the clinics. In fact, there is an emerging consensus that the detailed annotation of protein PTMs could lead to a more in-depth representation of biological systems, translating into more specific targets for therapy as well as biomarkers. Moreover, a recent trend is so-called “targeted proteomics”. The approach was awarded the title of “Method of the Year” by Nature in 2013 (see the editorial by Vivien Marx in 1st issue of Nature in Jan 2013). According to a few proteomic scientists the emphasis should not be placed on generating long lists of proteins but lists of proteins with a true biological meaning.

The ESC Handbook on Cardiovascular Pharmacotherapy, based on the most recent guidelines in cardiovascular pharmacology, and containing a comprehensive A-Z formulary of common and less commonly used cardiac drugs and drug groups, provides practical and accessible guidance on all areas of drugprescribing.Previously published as Drugs in Cardiology, this new edition has been developed by the ESC Working Group on Cardiovascular Pharmacology. Pharmacology is an integral aspect in almost all disciplines within cardiology and all cardiologists use cardiovascular drugs.Completely updated and aligned with the ESC Clinical Practice Guidelines for prescribing, this handbook is essential reading for consultants, registrars in training, general practitioners, specialist cardiac nurses and cardiovascular pharmacologists.

The ESC Handbook of Preventive Cardiology is a 'how-to' manual for busy healthcare professionals. Complementing the 2012 Joint European Guidelines on cardiovascular disease prevention and in line with recommendations from the European Association of Cardiac Prevention and Rehabilitation, it is an invaluable source of tools and skills to assist with the delivery of effective cardiovascular disease prevention. While acknowledging that cardiovascular disease prevention efforts must be complemented by societal and community based strategies, this handbook focuses on practical strategies that can be used in clinical settings. Concise and easily accessible, it guides readers through the patient and family pathway - from patient identification, recruitment of the patient and family, assessing lifestyle and risk factors, to managing lifestyle change, reducing risk factors, and compliance with cardio-protective drug therapies. Information on how to deliver a health promotion workshop programme and run a supervised exercise programme is also included. Previously published as Preventive Cardiology: A practical manual and now fully revised and updated and packed with checklists and diagrams, such as risk estimation charts, The ESC Handbook of Preventive Cardiology helps health workers contribute in real and practical ways to the prevention of artherosclerotic cardiovascular disease.