Histological Typing Of Oesophageal And Gastric Tumours

This is the revised edition of the WHO histological classification of oesophageal and gastric tumours. It reflects the important changes that haveoccurred since the first edition in the fields of lymphomas, endocrine tumours and the dysplasias as well as adding a number of newly describedentities. it sets the international standard for the next decade.

This classification is based primarily on the microscopic characteris tics of tumours. It is therefore concerned with the identification of cell types and histological patterns as seen by conventional light micro scopy. In general, time-honoured terms have been retained. Syn onyms are listed only if they have been widely used or if they are con sidered to be important for understanding the disease process. In such cases, the preferred term is given first, followed by the synonym in parentheses. The individuality of a tumour manifests itself principally in its histological appearance and the extent of spread at the time of diag nosis. This volume is concerned only with the histological classific ation of tumours. Anatomical extent or staging is covered in the TNM Classification.! The histological classification of a tumour de pends on two main parameters, typing and grading, and a number of additional parameters which may apply to selected examples. Histological Typing This divides tumours of a given organ into different types according to their direction of differentiation. Although this may frequently in dicate the underlying histogenesis of the tumour, it may be difficult or impossible to identify the cell of origin. Note is taken of the structure and function of cell types, as well as the overall growth pattern of the tumour, with the aim of matching these features to those of a normal tissue found in the same organ.

"The WHO Classification of Tumours of the Digestive System presented in this book reflects the views of a Working Group that convened for an Editorial and Consensus Conference at the International Agency for Research on Cancer (IARC), Lyon, December 10-12, 2009"--P. [5].

In collaboration with pathologists in 5 countries

This book includes more clinical aspects and concentrates on cancer and precancer of the oral mucosa rather than attempting to cover all benign and malignant tumours of the oral and oropharyngeal tissue. One main emphasis is the significance of the clinical features of the various lesions discussed. Attention is also drawn to those conditions particular to the oral mucosa that may give rise to appearances which are important in differential diagnoses but can be misleading to those who do not have detailed knowledge of the tissue involved. The TNM-classification for malignant tumours of the lip and oral cavity is also included.