Hormone Receptors In Breast Cancer

Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist. Advances in basic science of molecular endocrinology have undoubtedly been translated into clinical practice, and clinicians caring for this disease need to be knowledgeable about these developments. The molecular basis of hormone action has been elucidated, and the relative significance of the different estrogen and progesterone receptor isoforms has been explored. This explosion of information has lead to exciting new areas of gene specific targeting of the disease, and breast cancer prevention. Paradigm shifts in treatment options and sequencing have recently occurred in breast cancer management, necessitating close cooperation and communication between translational scientists and physicians. This book is focused on providing this communication.

Several papers dealing with the clinical relevance of steroid hormone receptors in breast cancer have already been published. However, no publication has overviewed studies currently being conducted in Europe, nor is there a register of the european centers performing receptor assays. It has been our purpose to fill these gaps. A large majority of authors who we contacted kindly agreed to con tribute to our book. Papers were grouped into six main parts according to their contents. The abundance of clinical data relevant to receptor assays led us to add critical summaries to help the reader to form his own opinions on the subject. We would like to thank Drs. R. J. B. King, G. Contesso, L. Santi, and E. Engelsman, who helped us in this regard. We hope that this book will enable the reader to become acquainted with the present state of European steroid hormone receptor studies devoted to breast cancer treatment. We also hope that it will promote cooperation between European oncologists involved in this field of research.

Estrogens have been implicated to play a role in the development of breast cancer. The purpose of this book is to provide a comprehensive analysis of experimental, clinical and epidemiological evidence in support of the carcinogenicity of estrogens.

The papers in this volume were presented at the Symposium on Hormones and Cancer held March 24-26, 1980, at the Worcester Foundation for Experimental Biology, Shrewsbury, MA. The meeting was organized to review recent advances in basic and clinical research work on hormone-responsive tumors of the reproductive system. The association between protracted hormone action and cancer of the reproductive system is now irrefutable. Yet we still do not know how hormones initiate and promote neoplastic transformation of their target cells. A major effort is cur rently being directed at understanding the hormonal regulation of neoplastic cells, especially those arising from the breast, uterus, pituitary gland and prostate. The symposium brought together leading experts whose research is focused on this impor tant area of human health. Although many questions remain to be answered by future studies, the material covered in this volume provides an up-to-date overview of the current status of work in this area. The subjects range from the mechanism of hormone action to the treatment of hormone-dependent tumors, and topics include estrogen, progestin, androgen and glucocorticoid action~ hormone receptors~ specific protein responses~ developmental effects of estrogens and antiestrogens~ the DES syndrome~ regu lation of the cell cycle~ therapeutic effects of antiestrogens, aromatase inhibitors, iodoestrogens, progestins on estrogen dependent tumors~ characterization of retinoid-binding sites~ and the utility of various tumor markers.

This volume presents the evolution of the authors' ideas about estrogen action and its modulation by a new group of drugs called SERMs (Selective Estrogen Receptor Modulators). The pioneering SERMs — tamoxifen and raloxifene — are known to have saved the lives of millions of women around the world and improved the health of millions more. Estrogen is the central hormone of women's health and reproduction. The book is a journey through 40 years of discovery and success in advancing women's health, with the prospect of improved innovation through medicinal chemistry for the future. Contents:A Century of Deciphering the Control Mechanisms of Estrogen Action in Breast Cancer: The Origins of Targeted Therapy and Chemoprevention (V Craig Jordan)Diethylstilbestrol: A Tragedy in Reproductive Endocrinology But a Pioneering Cancer Treatment (Joan Lewis-Wambi and V Craig Jordan)Oral Contraceptives and Women's Health (V Daniel Castracane and V Craig Jordan)Hormone Replacement Therapy and Women's Health (Jennifer Eng-Wong, Ifeyinwa Obiorah and V Craig Jordan)Induction of Ovulation by Nonsteroidal Antiestrogens (Ifeyinwa Obiorah and V Craig Jordan)Clues About Estrogen and Antiestrogen Action from X-Ray Crystallography (Geoffrey L Greene and V Craig Jordan)Coregulators and Their Role in Selective Estrogen Receptor Modulator Action (Christopher D Chien, Anton Wellstein and Anna Riegel)Role of Estrogen in Familial Breast Cancer (Eliot Rosen and Claudine Isaacs)Advances with Aromatase Inhibitors (Saranya Chumsri, Ting Bao, Gauri Sabnis and Angela Brodie)Adjuvant Antihormone Therapy (Anthony Howell and V Craig Jordan)Pharmacogenomics of Tamoxifen (Hiltrud B Brauch and V Craig Jordan)Antihormone Drug Resistance (Robert Clarke and V Craig Jordan)Novel Selective Estrogen Receptor Modulators (Surojeet Sengupta and V Craig Jordan)Endocrine Prevention of Breast Cancer (Trevor J Powles, Russell E McDaniel and V Craig Jordan)Selective Androgen Receptor Modulators as Improved Androgen Therapy for Women (Christopher C Coss and James T Dalton)An Emerging Principle: Selective Nuclear Receptor Modulators (Ping Fan and V Craig Jordan) Readership: Clinicians, biological faculty, informed patients, scientists and students in biology and medicine, healthcare and medical professionals, breast cancer survivors. Keywords:Estrogen;Women's Health;SERMs;Breast Cancer;Tamoxifen;Raloxifene;DESKey Features:A unique easy-to-read book for clinicians, biological faculty, informed patients, scientists and medical professionalsFocuses on the evolution of estrogen action in women's health and changes in healthcare through scientific researchA concise summary of progressNo other competing titles of the same caliberWritten by the pioneers in the field

Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.