Image Based Computational Modeling Of The Human Circulatory And Pulmonary Systems

Image-Based Computational Modeling of the Human Circulatory and Pulmonary Systems provides an overview of the current modeling methods and applications enhancing interventional treatments and computer-aided surgery. A detailed description of the techniques behind image acquisition, processing and three-dimensional reconstruction are included. Techniques for the computational simulation of solid and fluid mechanics and structure interaction are also discussed, in addition to various cardiovascular and pulmonary applications. Engineers and researchers involved with image processing and computational modeling of human organ systems will find this a valuable reference.

Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Artificial Intelligence for Computational Modeling of the Heart presents recent research developments towards streamlined and automatic estimation of the digital twin of a patient's heart by combining computational modeling of heart physiology and artificial intelligence. The book first introduces the major aspects of multi-scale modeling of the heart, along with the compromises needed to achieve subject-specific simulations. Reader will then learn how AI technologies can unlock robust estimations of cardiac anatomy, obtain meta-models for real-time biophysical computations, and estimate model parameters from routine clinical data. Concepts are all illustrated through concrete clinical applications. Presents recent advances in computational modeling of heart function and artificial intelligence technologies for subject-specific applications Discusses AI-based technologies for robust anatomical modeling from medical images, data-driven reduction of multi-scale cardiac models, and estimations of physiological parameters from clinical data Illustrates the technology through concrete clinical applications and discusses potential impacts and next steps needed for clinical translation

Designed for senior undergraduate or first-year graduate students in biomedical engineering, Biofluid Mechanics: The Human Circulation, Second Edition teaches students how fluid mechanics is applied to the study of the human circulatory system. Reflecting changes in the field since the publication of its predecessor, this second edition has been ex

Mathematical models and numerical simulations can aid the understanding of physiological and pathological processes. This book offers a mathematically sound and up-to-date foundation to the training of researchers and serves as a useful reference for the development of mathematical models and numerical simulation codes.

Biomedical Engineering Modeling of Pancreatic, Respiratory, and Renal Regulatory Systems, and their Medical Assessments addresses the need for biomedical engineering to provide physiological analysis of organ systems and their medical applications to help enable quantitative formulation of physiological systems and defining their functions and dysfunctions, leading to precision diagnostics of diabetes, lung diseases, and kidney failure, often in the form of non-dimensional indices. The book chapters also deal with treatment systems, namely automated insulin infusion systems, hemodialysis, and peritoneal dialysis. The book is formulated to solve many physiological, bioengineering, and medical problems. Covers foundational concepts of the emerging fields of quantitative physiology and computational medicine, developing the biomedical engineering modeling of three important organ systems: pancreas, lungs, and kidneys Provides readers with detailed understanding of novel biomedical engineering strategies in key areas, such as pancreatic system engineering, glucose-insulin regulatory system engineering, pulmonary system engineering, and renal system engineering Provides in-depth technical coverage of computational modeling techniques and applied mathematics for these important physiological systems, including differential equations and the associated MATLAB datasets for all applied diagnostic and treatment examples

Mathematicalmodelingofhumanphysiopathologyisatremendouslyambitioustask. It encompasses the modeling of most diverse compartments such as the cardiovas- lar,respiratory,skeletalandnervoussystems,aswellasthemechanicalandbioch- ical interaction between blood ?ow and arterial walls, and electrocardiac processes and electric conduction in biological tissues. Mathematical models can be set up to simulate both vasculogenesis (the aggregation and organization of endothelial cells dispersed in a given environment) and angiogenesis (the formation of new vessels sprouting from an existing vessel) that are relevant to the formation of vascular networks, and in particular to the description of tumor growth. The integration of models aimed at simulating the cooperation and interrelation of different systems is an even more dif?cult task. It calls for the setting up of, for instance, interaction models for the integrated cardio-vascular system and the interplay between the central circulation and peripheral compartments, models for the mid-to-long range cardiovascular adjustments to pathological conditions (e.g., to account for surgical interventions, congenital malformations, or tumor growth), models for integration among circulation, tissue perfusion, biochemical and thermal regulation, models for parameter identi?cation and sensitivity analysis to parameter changes or data uncertainty – and many others.

Learn to calculate drug dosages safely, accurately, and easily with Kee’s Clinical Calculations, 9th Edition! This market-leading text covers all four major drug calculation methods, including ratio & proportion, formula, fractional equation, and dimensional analysis. It also includes practice problems for both general care as well as specialty areas such as pediatrics, labor and delivery, critical care, and community nursing. With its market-leading, comprehensive coverage; strong emphasis on patient safety; and the incorporation of the latest information on antidiabetic agents, anticoagulant agents, drug administration techniques, and devices; Kee remains the winning choice for easy drug calculation mastery. Coverage of all four major drug calculation methods includes ratio & proportion, formula, fractional equation, and dimensional analysis to help you learn and apply the method that works best for you. The latest information on drug administration techniques and devices helps you master the most up-to-date techniques of drug administration, including oral, intravenous, intra-muscular, subcutaneous, and other routes. Caution boxes provide alerts to problems or issues related to various drugs and their administration. Information on infusion pumps covers enteral, single, multi-channel, PCA, and insulin; and explains their use in drug administration. Calculations for Specialty Areas section addresses the drug calculations needed to practice in pediatric, critical care, labor and delivery, and community settings. Detailed, full-color photos and illustrations show the most current equipment for IV therapy, the latest types of pumps, and the newest syringes. Comprehensive post-test lets you test your knowledge of key concepts from the text. NEW! Updated information on Antidiabetic Agents (orals and injectables) has been added throughout the text where appropriate. NEW! Updated content on Anticoagulant Agents is housed in an all-new chapter. NEW! Colorized abbreviations for the four methods of calculation (BF, RP, FE, and DA) appear in the Example Problems sections. NEW! Updated content and patient safety guidelines throughout the text reflects the latest practices and procedures. NEW! Updated practice problems across the text incorporate the latest drugs and dosages.