Imaging The Future

This book includes some very recent applications and the newest emerging trends of hyper-spectral imaging (HSI). HSI is a very recent and strange beast, a sort of a melting pot of previous techniques and scientific interests, merging and concentrating the efforts of physicists, chemists, botanists, biologists, and physicians, to mention just a few, as well as experts in data crunching and statistical elaboration. For almost a century, scientific observation, from looking to planets and stars down to our own cells and below, could be divided into two main categories: analyzing objects on the basis of their physical dimension (recording size, position, weight, etc. and their variations) or on how the object emits, reflects, or absorbs part of the electromagnetic spectrum, i.e., spectroscopy. While the two aspects have been obviously entangled, instruments and skills have always been clearly distinct from each other. With HSI now available, this is no longer the case. This instrument can return specimen dimensionalities and spectroscopic properties to any single pixel of your specimen, in a single set of data. HSI modality is ubiquitous and scale-invariant enough to be used to mark terrestrial resources on the basis of a land map obtained from satellite observation (actually, the oldest application of this type) or to understand if the cell you are looking at is cancerous or perfectly healthy. For all these reasons, HSI represents one of the most exciting methodologies of the new millennium.

Brings a fresh point of view to the current state of correlative imaging and the future of the field This book provides contributions from international experts on correlative imaging, describing their vision of future developments in the field based on where it is today. Starting with a brief historical overview of how the field evolved, it presents the latest developments in microscopy that facilitate the correlative workflow. It also discusses the need for an ideal correlative probe, applications in proteomic and elemental analysis, interpretation methods, and how correlative imaging can incorporate force microscopy, soft x-ray tomography, and volume electron microscopy techniques. Work on placing individual molecules within cells is also featured. Correlative Imaging: Focusing on the Future offers in-depth chapters on: correlative imaging from an LM perspective; the importance of sample processing for correlative imaging; correlative light and volume EM; correlation with scanning probe microscopies; and integrated microscopy. It looks at: cryo-correlative microscopy; correlative cryo soft X-ray imaging; and array tomography. Hydrated-state correlative imaging in vacuo, correlating data from different imaging modalities, and big data in correlative imaging are also considered. Brings a fresh view to one of the hottest topics within the imaging community: the correlative imaging field Discusses current research and offers expert thoughts on the field’s future developments Presented by internationally-recognized editors and contributors with extensive experience in research and applications Of interest to scientists working in the fields of imaging, structural biology, cell biology, developmental biology, neurobiology, cancer biology, infection and immunity, biomaterials and biomedicine Part of the Wiley–Royal Microscopical Society series Correlative Imaging: Focusing on the Future will appeal to those working in the expanding field of the biosciences, correlative microscopy and related microscopic areas. It will also benefit graduate students working in microscopy, as well as anyone working in the microscopy imaging field in biomedical research.

This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.

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Imaging science has the power to illuminate regions as remote as distant galaxies, and as close to home as our own bodies. Many of the disciplines that can benefit from imaging share common technical problems, yet researchers often develop ad hoc methods for solving individual tasks without building broader frameworks that could address many scientific problems. At the 2010 National Academies Keck Futures Initiative Conference on Imaging Science, researchers from academia, industry, and government formed 14 interdisciplinary teams created to find a common language and structure for developing new technologies, processing and recovering images, mining imaging data, and visualizing it effectively. The teams spent nine hours over two days exploring diverse challenges at the interface of science, engineering, and medicine. NAKFI Seeing the Future with Imaging Science contains the summaries written by each team. These summaries describe the problem and outline the approach taken, including what research needs to be done to understand the fundamental science behind the challenge, the proposed plan for engineering the application, the reasoning that went into it, and the benefits to society of the problem solution.

Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imagingâ€"the ability to visualize molecular structures and chemical composition in time and space as actual events unfoldâ€"from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.

This book provides up-to-date and practical knowledge in all aspects of whole slide imaging (WSI) by experts in the field. This includes a historical perspective on the evolution of this technology, technical aspects of making a great whole slide image, the various applications of whole slide imaging and future applications using WSI for computer-aided diagnosis The goal is to provide practical knowledge and address knowledge gaps in this emerging field. This book is unique because it addresses an emerging area in pathology for which currently there is only limited information about the practical aspects of deploying this technology. For example, there are no established selection criteria for choosing new scanners and a knowledge base with the key information. The authors of the various chapters have years of real-world experience in selecting and implementing WSI solutions in various aspects of pathology practice. This text also discusses practical tips and pearls to address the selection of a WSI vendor, technology details, implementing this technology and provide an overview of its everyday uses in all areas of pathology. Chapters include important information on how to integrate digital slides with laboratory information system and how to streamline the “digital workflow” with the intent of saving time, saving money, reducing errors, improving efficiency and accuracy, and ultimately benefiting patient outcomes. Whole Slide Imaging: Current Applications and Future Directions is designed to present a comprehensive and state-of the-art approach to WSI within the broad area of digital pathology. It aims to give the readers a look at WSI with a deeper lens and also envision the future of pathology imaging as it pertains to WSI and associated digital innovations.

Imaging science has the power to illuminate regions as remote as distant galaxies, and as close to home as our own bodies. Many of the disciplines that can benefit from imaging share common technical problems, yet researchers often develop ad hoc methods for solving individual tasks without building broader frameworks that could address many scientific problems. At the 2010 National Academies Keck Futures Initiative Conference on Imaging Science, researchers from academia, industry, and government formed 14 interdisciplinary teams created to find a common language and structure for developing new technologies, processing and recovering images, mining imaging data, and visualizing it effectively. The teams spent nine hours over two days exploring diverse challenges at the interface of science, engineering, and medicine. NAKFI Seeing the Future with Imaging Science contains the summaries written by each team. These summaries describe the problem and outline the approach taken, including what research needs to be done to understand the fundamental science behind the challenge, the proposed plan for engineering the application, the reasoning that went into it, and the benefits to society of the problem solution.