In Search Of Cell History

The origin of cells remains one of the most fundamental problems in biology, one that over the past two decades has spawned a large body of research and debate. In this book, the author offers a comprehensive, impartial take on that research and the controversies that keep the field in turmoil.

This book discusses central concepts and theories in cell biology from the ancient past to the 21st century, based on the premise that understanding the works of scientists like Hooke, Hofmeister, Caspary, Strasburger, Sachs, Schleiden, Schwann, Mendel, Nemec, McClintock, etc. in the context of the latest advances in plant cell biology will help provide valuable new insights. Plants have been an object of study since the roots of the Greek, Chinese and Indian cultures. Since the term “cell” was first coined by Robert Hooke, 350 years ago in Micrographia, the study of plant cell biology has moved ahead at a tremendous pace. The field of cell biology owes its genesis to physics, which through microscopy has been a vital source for piquing scientists’ interest in the biology of the cell. Today, with the technical advances we have made in the field of optics, it is even possible to observe life on a nanoscale. From Hooke’s observations of cells and his inadvertent discovery of the cell wall, we have since moved forward to engineering plants with modified cell walls. Studies on the chloroplast have also gone from Julius von Sachs’ experiments with chloroplast, to using chloroplast engineering to deliver higher crop yields. Similarly, advances in fluorescent microscopy have made it far easier to observe organelles like chloroplast (once studied by Sachs) or actin (observed by Bohumil Nemec). If physics in the form of cell biology has been responsible for one half of this historical development, biochemistry has surely been the other.

Elegant, suggestive, and clarifying, Lewis Thomas's profoundly humane vision explores the world around us and examines the complex interdependence of all things. Extending beyond the usual limitations of biological science and into a vast and wondrous world of hidden relationships, this provocative book explores in personal, poetic essays to topics such as computers, germs, language, music, death, insects, and medicine. Lewis Thomas writes, "Once you have become permanently startled, as I am, by the realization that we are a social species, you tend to keep an eye out for the pieces of evidence that this is, by and large, good for us."

Although modern cell biology is often considered to have arisen following World War II in tandem with certain technological and methodological advances—in particular, the electron microscope and cell fractionation—its origins actually date to the 1830s and the development of cytology, the scientific study of cells. By 1924, with the publication of Edmund Vincent Cowdry’s General Cytology, the discipline had stretched beyond the bounds of purely microscopic observation to include the chemical, physical, and genetic analysis of cells. Inspired by Cowdry’s classic, watershed work, this book collects contributions from cell biologists, historians, and philosophers of science to explore the history and current status of cell biology. Despite extraordinary advances in describing both the structure and function of cells, cell biology tends to be overshadowed by molecular biology, a field that developed contemporaneously. This book remedies that unjust disparity through an investigation of cell biology’s evolution and its role in pushing forward the boundaries of biological understanding. Contributors show that modern concepts of cell organization, mechanistic explanations, epigenetics, molecular thinking, and even computational approaches all can be placed on the continuum of cell studies from cytology to cell biology and beyond. The first book in the series Convening Science: Discovery at the Marine Biological Laboratory, Visions of Cell Biology sheds new light on a century of cellular discovery.

"...This volume is presented as a story or history starting from the moment Mankind began to peek into the microscopic world of cells and microbes with the invention of microscopes-and even earlier, much earlier-continuing through landmark events of false starts and new insights put away for the wrong reasons etc., etc., culminating in the association-induction hypothesis of today."--vii.

Franklin M. Harold's On Life reveals what science can tell us about the living world. All creatures, from bacteria and redwoods to garden snails and humans, belong to a single biochemical family. We all operate by the same principles and are all made up of cells, either one or many. We flaunt capacities that far exceed those of inanimate matter, yet we stand squarely within the material world. So what is life, anyway? How do living things function, and how did they come into existence? Questions like these have baffled philosophers and scientists since antiquity, but over the past half-century answers have begun to emerge. Offering an inside look, Franklin M. Harold makes life accessible to readers interested in the biological big picture. The book traces how living things operate, focusing on the interplay of biology with physics and chemistry. He asserts that biology stands apart from the physical sciences because life revolves around organization-- that is, purposeful order. On Life aims to make life intelligible by giving readers an understanding of the biological landscape; it sketches the principles as biologists presently understand them and highlights major unresolved issues. What emerges is a biology bracketed by two stubborn mysteries: the nature of the mind and the origin of life. This portrait of biology is comprehensible but inescapably complex, internally consistent, and buttressed by a wealth of factual knowledge.

"Cell biology is becoming an increasingly quantitative field, as technical advances mean researchers now routinely capture vast amounts of data. This handbook is an essential guide to the computational approaches, image processing and analysis techniques, and basic programming skills that are now part of the skill set of anyone working in the field"--