Interactions Of Copper And Other Metal Ions With Bacteria

Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked in animal and human studies. This book focuses on the distribution, trafficking, fate, and effects of trace metals in biological systems. Its goal is to enhance our understanding of the relationships between homeostatic mechanisms of trace metals and the pathogenesis of infectious diseases. Drawing on expertise from a range of fields, the book offers a comprehensive review of current knowledge on vertebrate metal-withholding mechanisms and the strategies employed by different microbes to avoid starvation (or poisoning). Chapters summarize current, state-of-the-art techniques for investigating pathogen-metal interactions and highlight open question to guide future research. The book makes clear that improving knowledge in this area will be instrumental to the development of novel therapeutic measures against infectious diseases. Contributors M. Leigh Ackland, Vahid Fa Andisi, Angele L. Arrieta, Michael A. Bachman, J. Sabine Becker, Robert E. Black, Julia Bornhorst, Sascha Brunke, Joseph A. Caruso, Jennifer S. Cavet, Anson C. K. Chan, Christopher H. Contag, Heran Darwin, George V. Dedoussis, Rodney R. Dietert, Victor J. DiRita, Carol A. Fierke, Tamara Garcia-Barrera, David P. Giedroc, Peter-Leon Hagedoorn, James A. Imlay, Marek J. Kobylarz, Joseph Lemire, Wenwen Liu, Slade A. Loutet, Wolfgang Maret, Andreas Matusch, Trevor F. Moraes, Michael E. P. Murphy, Maribel Navarro, Jerome O. Nriagu, Ana-Maria Oros-Peusquens, Elisabeth G. Pacyna, Jozef M. Pacyna, Robert D. Perry, John M. Pettifor, Stephanie Pfaffen, Dieter Rehder, Lothar Rink, Anthony B. Schryvers, Ellen K. Silbergeld, Eric P. Skaar, Miguel C. P. Soares, Kyrre Sundseth, Dennis J. Thiele, Richard B. Thompson, Meghan M. Verstraete, Gonzalo Visbal, Fudi Wang, Mian Wang, Thomas J. Webster, Jeffrey N. Weiser, Günter Weiss, Inga Wessels, Bin Ye, Judith T. Zelikoff, Lihong Zhang

This volume of Current Topics in Membranes focuses on metal transmembrane transporters and pumps, a recently discovered family of membrane proteins with many important roles in the physiology of living organisms. The book summarizes the most recent advances in the field of metal ion transport and provides a broad overview of the major classes of transporters involved in homeostasis of heavy metals. Various families of the transporters and metal specificities are discussed with the focus on the structural and mechanistic aspects of their function and regulation. The reader will access information obtained through a variety of approaches ranging from X-ray crystallography to cell biology and bioinformatics, which have been applied to transporters identified in diverse biological systems, such as pathogenic bacteria, plants, humans and others. Field is cutting-edge and a lot of the information is new to research community Wide breadth of topic coverage Contributors of high renown and expertise

This book provides a detailed description and analysis of the reduction and metabolism of metals and metalloids by sulfate reducing bacteria. The molecular mechanisms of bacterial resistance to copper are examined as well as extracellular electron transfer and bacterial metal oxide respiration. Furthermore, in this book enrichment, isolation, and physiology of magnetotactic bacteria are discussed. The interactions of bacteria with metals in natural environments and their role in metal cycling have been studied for decades. Advances in studies of bacteria-metal interactions identified numerous important aspects of these interactions, such as bioremediation of metal-contaminated environments, the role of metals in redox reactions and other cellular functions, as well as the role of metals in toxicity and infection. Microbiologists, environmental scientists, and students interested in microbe interactions with metals and their effect on the environment and their application in biotechnology will be interested in the topics discussed in the book.

In the past two decades, great progress has been made in the understanding of copper as a bioelement. The book summarizes the current knowledge of copper toxicity, homeostasis and resistance in bacteria, in which proteins like copper ATPases, copper chaperones and copper-responsive regulators of gene expression play major roles. The author also discusses the metallation of cuproenzymes. The evolution of the use of copper by cells and of copper-homeostatic proteins are is also considered in this Brief.

This is Volume 9 of the ninth International Symposium on Metal Ions in Biology and Medicine that was held in Lisbon, Portugal in May 2006. It comprises a host of papers from internationally regarded authorities in the field.

This Research Topic presents knowledge on transition metal metabolism in various infections from the dual perspective of offender and defender. 1) Host Nutritional Immunity: depriving or poisoning. To date, the implication of divalent metals have been described in two different immune strategies that aim to fight microbial invaders. One consists in depriving microbes of essential divalent metals whereas the other aims at overloading invaders with toxic concentrations of metal. The contributions in this section present, in different situations, various aspects of this metal economy at the host-microbe interface. Two papers deal with metal homeostasis as hosts interact with bacteria. Diaz-Ochoa et al. (2014) review immunological mechanisms to sequester Fe, Mn and Zn in the inflamed gut and strategies of commensals and pathogens to evade mucosal defenses and obtain such nutrients. Lisher & Giedroc (2013) detail chemical and structural mechanisms to capture Mn, an antioxidant used by pathogens to adapt to human hosts, and the impact of Fe and Zn on Mn bioavailability during infections. The most coveted metal, iron is key to nutritional immunity and microbial virulence. Using amoeba as model phagocyte, Bozzaro et al. (2013) present the tug of war between a bacterial predator, sequestering intracellular iron to resist invasion, and pathogens which elude such defense mechanisms. On mammalian defense against intracellular bacteria and protozoan parasites, Silva-Gomes et al. (2013) outline divergent approaches: iron-withholding to prevent microbial replication or iron-based oxidative injury to kill invaders. Host may also target invaders with toxic doses of Cu and Zn, normally kept at low concentrations. Neyrolles et al. (2013) present an opinion article on bacterial Zn and Cu poisoning in the context of Mycobacterium tuberculosis infection. Chaturvedi & Henderson (2014) summarize the specific properties of copper and its toxic effect on bacteria cells. Argüello et al. (2013) review how bacteria integrate homeostatic mechanisms to avoid Cu toxicity by sensing and regulating ion chelation, chaperoning and membrane transport. 2) Microbial adaptation to host defenses: metallo-transporters or exporters. To overcome host resistance to infection, numerous mechanisms have been selected through the course of microbial evolution, in particular transporters that can feed the bacteria even at low metal concentration or, on the contrary, metallo-exporters that can expel metals outside the cell to avoid toxic accumulation. The articles in this section describe the microbial transport arsenal, and its regulation, which play major roles to influence metal economy at the host-microbe interface. Bacterial and fungal strategies to acquire Fe is the subject of four contributions. Liu & Biville (2013) discuss erythrocyte parasitism by Bartonella, transmitted by arthropod vectors and relying principally on heme capture and oxidative stress defense to cause persistent infections. Runyen-Janecky (2013) highlights some of the recent findings on heme iron acquisition system and the regulation of their expression in Gram-negative pathogens. Cornelis & Dingemans (2013) recap how Pseudomonas adapts means of iron capture to the type of infection it establishes, acute or chronic. Caza & Kronstad (2013) contrast strategies of virulent bacteria and fungi to subvert host immunity and steal iron from hemoglobin, heme, transferrin and lactoferrin or elemental iron using specialized uptake systems and siderophores. Five papers deal with microbial homeostasis of other metals Mn, Ni and Zn. Honsa et al. (2013) review the roles of importers and exporters of Mn, Fe, Zn and Cu in Streptococcus pneumoniae gene regulation and tissue-specific pathogenesis. Guilhen et al (2013) focus on families of exporters and the role of metal efflux in the evolution of Neisseria meningitidis virulence and naso-pharyngeal c

Biocompatible Hybrid Oxide Nanoparticles for Human Health: From Synthesis to Applications explores the synthesis, structure, properties and applications of functionalized oxide nanoparticles. The books shows the applications of materials depending on their composition and structure, with a focus on silicon, titanium and iron oxides, each of which was chosen because of their unique features, including silica because it is chemically resistant to most organic solvents, harmless to living organisms, can thicken flowable formulations, and increase the strength of materials, titania for its unique chemical, optical, electrophysical and bactericidal properties, and iron-containing materials because they possess important magnetic properties. Shows how oxide nanoparticles are being used to solve current problems in the fields of environmental protection, medicine, and in the creation of "smart" materials Includes case studies that explore the major characteristics and applications of silica, titania and iron oxide nanomaterials Discusses the use of biocompatible oxide nanostructures in the development of new sensing technology

The safety of the nation's drinking water must be maintained to ensure the health of the public. The U.S. Environmental Protection Agency (EPA) is responsible for regulating the levels of substances in the drinking water supply. Copper can leach into drinking water from the pipes in the distribution system, and the allowable levels are regulated by the EPA. The regulation of copper, however, is complicated by the fact that it is both necessary to the normal functioning of the body and toxic to the body at too high a level. The National Research Council was requested to form a committee to review the scientific validity of the EPA's maximum contaminant level goal for copper in drinking water. Copper in Drinking Water outlines the findings of the committee's review. The book provides a review of the toxicity of copper as well as a discussion of the essential nature of this metal. The risks posed by both short-term and long-term exposure to copper are characterized, and the implications for public health are discussed. This book is a valuable reference for individuals involved in the regulation of water supplies and individuals interested in issues surrounding this metal.