Ivermectin

Ivermectin and abamectin, members of the avermectin family of compounds, were introduced to the market in the 1980's as a veterinary antiparasitic drug and agricultural pesticide, respectively. Their acceptance and commercial success have been remarkable; both are highly effective and in worldwide use. The efficacy of ivermectin in river blindness has expanded the interest in its use in human medicine. In response to the intense scientific and industrial interest in ivermectin and abamectin and the likelihood that they will be forerunners of an expanding family of drugs, this comprehensive monograph satisfies the need for a review and synthesis of current knowledge about the use of these substances in crop protection as well as in cattle, sheep, swine, horses, dogs, cats, birds, fish, reptiles, and in man. This overview presents chemical, biochemical, and microbiological data, as well as pharmacological, safety, and environmental aspects and covers practical use of the compounds as antiparasitic and pesticide agents, as well as the available safety data that have emerged from the clinical experience with human applications.

Anthology of the Pandemic and history of the story of Ivermectin

Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. Includes the authority and expertise of leading contributors in pharmacology Presents the latest release in the Advances in Pharmacology series

Discover a wealth of important information about the drug, ivermectin inside my book, The Essential Guide to Ivermectin: Usage, Precautions, Interactions and Side Effects. A must-read book to learn about the conditions that ivermectin is used to treat through to the range of potentially life-threatening side effects and drug interactions that can occur while taking this commonly prescribed medication. Inside my new book you will discover: Ivermectin Brand Names. A comprehensive listing of ivermectin brand name medications in the United States, Canada and Europe, never be unsure about the medications you are taking again by being able to identify what brand name medications contain ivermectin. Medical Conditions Ivermectin Treats. Discover the wide range of medical conditions that a course of ivermectin can treat, cure and prevent. Know what your doctor or medical professional may prescribe for certain conditions before going into the doctor’s office. Risks of Taking Ivermectin. As with all medications there are some inherent risks when taking ivermectin, learn what these risks are, how to identify them with your medical professional or doctor and what signs to look for in case of an emergency. Ivermectin Side Effects & Interactions. From drug interactions, allergies and more, discover the variety of interactions that you need to know about before starting a prescribed course of ivermectin medications and what to do if a reaction should occur during or after completing your prescribed course of ivermectin. Alternative Medications. A list of alternative medications that can be substituted for ivermectin to enable you to make an informed decision about your overall health care. This is especially useful for individuals concerned about the negative side effects or interactions with other drugs when taking ivermectin. Plus, so much more... Start reading my book right now and arm yourself with the information you need to make an educated decision when weighing the risks and benefits of taking the common prescription drug, ivermectin.

CHEMISTRY AND BIOLOGICAL ACTIVITIES OF IVERMECTIN The book focuses on the biological activities of ivermectin as well as the significant global utility of IVM since it was first used about 35 years ago. Ivermectin (IVM) is a “wonder drug” containing a 16-membered macrocyclic lactone ring system in its structure and derived from the family of avermectins. It was isolated by the fermentation of the soil microorganism Streptomyces avermitilis by Satoshi Omura in 1960 and studied by William C. Campbell in 1981, which allowed for its treatment of onchocerciasis (River Blindness) in Africa. Both scientists subsequently received the 2015 Nobel Prize in Physiology or Medicine. It was approved by the FDA in 1997 for the treatment of Strongyloidiasis and crusted scabies in AIDS patients. After that, IVM has attracted the tremendous attention of the scientific community and has been used for diverse purposes, including as an inhibitor of the causative virus (SARS-CoV-2). The chief purpose of this volume is to focus on the chemistry and biological activities of ivermectin. The chapters have been arranged in a systematic manner, starting from the historical background and synthesis of IVM to the pharmacological and environmental aspects, followed by diverse applications. Although the usage of ivermectin for the treatment of COVID-19 remains under investigation and controversial, one of the chapters is dedicated to its use. The anti-parasitic, anti-malarial, anti-cancer, and anti-inflammatory activities of IVM are discussed in detail. The anthelminthic and insecticidal roles of IVM are briefly described and there are several cases of IVM in dermatology. Audience Researchers, scientists, and postgraduate students working in the fields of organic synthesis, medicinal chemistry, medical science, pharmacy, biotechnology and biomedical sciences.

Big Pharma and health agencies cry, “Don’t take ivermectin!” A media storm follows. Why then, does the science say the opposite?” Ivermectin is a dirty word in the media. It doesn’t work. It’s a deadly horse dewormer. Prescribe or promote it and you’ll be called a right-wing quack, be banned from social media, or lose your license to practice medicine. And yet, entire countries wiped out the virus with it, and more than ninety-five studies now show it to be unequivocally effective in preventing and treating Covid-19. If it didn’t work, why was there a coordinated global campaign to cancel it? What’s the truth about this decades-old, Nobel Prize-winning medication? The War on Ivermectin is the personal and professional narrative of Dr. Pierre Kory and his crusade to recommend a safe, inexpensive, generic medicine as the key to ending the pandemic. Written with Jenna McCarthy, Dr. Kory’s story chronicles the personal attacks, professional setbacks, and nefarious efforts of the world’s major health agencies and medical journals to dismiss and deny ivermectin’s efficacy. Part personal narrative, part scathing expose, The War on Ivermectin highlights the catastrophic impacts of the mass media censorship and relentless propaganda that led to the greatest humanitarian crisis in history. Although numerous studies and epidemiologic data have shown that millions of lives were saved globally with the systematic use of ivermectin, many more millions perished. This carnage was the direct result of what Dr. Kory eventually discovered to be the pharmaceutical industry’s silent but deadly war on generic medicines and the corrupt, captured medical and media systems that allow it to continue. For anyone who thought Covid-19 was the enemy, Dr. Kory’s book will leave no doubt that the true adversary in this war is a collective cabal of power-hungry elites who put profits over people and will stop at nothing in their quest for control. The War on Ivermectin is published through ICAN PRESS, an imprint of Skyhorse Publishing. ICAN (Informed Consent Action Network) is a nonprofit organization investigating the safety of medical procedures, pharmaceutical drugs, and vaccines while advocating for people’s right to informed consent.

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.