James Till And Ernest Mcculloch

Biophysicist James Till and cellular biologist Ernest McCulloch changed the world when they discovered stem cells in the 1960s. Through informative images and an accessible narrative, readers will learn how differences in their upbringings, fields of study, and even personalities helped their groundbreaking work. In this extensive look at the world of stem cells, then and now, students will experience the excitement of the Canadian duo's discovery and the impact it had, as well as learn the intricacies of the scientists' laboratory work and its long-reaching effects.

In proving the existence of stem cells, Ernest Armstrong McCulloch and James Edgar Till formed the most important partnership in Canadian medical research since Frederick Banting and Charles Best, the discoverers of insulin. Together, Till and McCulloch instructed, influenced, and inspired successive generations of researchers who have used their findings to make huge advances against disease. Thousands of people who would have died from leukemia and immunological disorders now owe their lives to therapies developed from their discoveries. Despite their accomplishments, Till and McCulloch remain largely unknown, and until now, their story has remained untold. Dreams and Due Diligence vividly chronicles the work of two researchers who made medical history – two men who possessed exactly the right complementary talents to achieve greatness and win nearly every award available in medical research. Bringing their legacy to life for the first time, Joe Sornberger provides a dramatic account of the development of stem cell research, one of today's most ground-breaking medical scientific fields.

This book brings together in one volume fifteen discoveries that have had a major impact upon medical science and the practice of medicine but where the scientists involved have not been awarded a Nobel Prize. Its aim is to publicize the achievements of these lesser-known heroes of our time and thereby inform and entertain the reader, whether medical student, professor or scientifically-minded layman. Contents:Archibald E Garrod: The Founding Father of Biochemical Genetics (David J Galton)Nikolai Anitschkow: The Birth of the Lipid Hypothesis of Atherosclerosis and Coronary Heart Disease (Daniel Steinberg)Willem-Karel Dicke: The Role of Gluten in Coeliac Disease (Chris J J Mulder and Karel A Dicke)Richard Doll: The Link Between Smoking and Lung Cancer (Tony Seed)Albert Sabin: The Development of an Oral Poliovirus Vaccine (Derek R Smith and Peter A Leggat)René Favaloro: Pioneer of Coronary Artery Surgery (Stephen Westaby)Christiaan Barnard and Norman Shumway: The Heart Transplant Pioneers (Stephen Westaby and David Marais)William Kouwenhoven and Paul Zoll: The Introduction of External Cardiac Massage, Defibrillators and Pacemakers (Max Lab)Inge Edler and Carl Hellmuth Hertz: The Development of Ultrasound for Clinical Use (Bhavna Batohi and Paul S Sidhu)Cyril Clarke, Ronald Finn, John Gorman, Vincent Freda and William Pollack: The Prevention of Rh Haemolytic Disease of the Newborn (David J Weatherall)Herbert Boyer and Stanley Cohen: Recombinant DNA (Anne Soutar)Harvey Alter and Michael Houghton: The Discovery of Hepatitis C and the Introduction of Screening to Prevent Its Transmission in Transfused Blood (Leonard B Seeff and Marc G Ghany)Willem Kolff and Belding Scribner: The Development of Renal Haemodialysis (John Turney)James Till and Ernest Mcculloch: The Discovery of Stem Cells (Joe Sornberger)Akira Endo: The Discovery of Statins (Gilbert Thompson and Hiroshi Mabuchi) Readership: Medical students, professionals and general public. Key Features:This book is the sequel to Nobel Prizes that Changed Medicine. Many of the authors have personal knowledge of the scientists they write about and all are distinguished authorities in their own field. No other book has brought together the non-Nobel Prize-winning discoveries having the greatest influence upon the practice of Medicine, dating from the first description of inborn errors of metabolism by Garrod in 1908 to the discovery of statins, for which Endo received the Lasker Award in 2008Keywords:Inborn Errors;Metabolism;Lipid Hypothesis;Atherosclerosis;Gluten;Coeliac Disease;Smoking;Lung Cancer;Polio Vaccine;Coronary Angiography;Coronary Bypass Grafting;Cardiac Transplantation;Cardiac Massage;Defibrillator;Pace Maker;Ultrasound;Rh Disease;Gene Cloning;Hepatitis C;Haemodialysis;Stem-Cells;Statins

Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

This book discusses critical areas of progress in stem cell research, including the most recent research and applications of pluripotent embryonic cells, induced pluripotent cells, oligopotent tissue stem cells and cancer stem cells. The text covers basic knowledge of stem cell biology, stem cell ethics, development of techniques for applying stem cell therapy, the technology of obtaining appropriate cells for transplantation as well as the role of stem cells in cancer and how therapy may be directed to cancer stem cells. This new volume is essential reading for all scientists currently in the field or allied research areas, and those for those graduate students who envision a career in stem cells.

This book collects articles on the biology of hematopoietic stem cells during embryonic development, reporting on fly, fish, avian and mammalian models. The text invites a comparative overview of hematopoietic stem cell generation in the different classes, emphasizing conserved trends in development. The book reviews current knowledge on human hematopoietic development and discusses recent breakthroughs of relevance to both researchers and clinicians.

A transnational history of how Indigenous peoples mobilised en masse to support the war effort on the battlefields and the home fronts.