Jefferson S Disease

This book points the way to a just democracy.

Thomas Jefferson died on July 4, 1826, leaving behind a series of mysteries that captured the imaginations of historical investigators-an interest rekindled by the recent revelation that he fathered a child by Sally Hemmings, a woman he legally owned-yet there is still surprisingly little known about him as a man. In Jefferson's Secrets Andrew Burstein focuses on Jefferson's last days to create an emotionally powerful portrait of the uncensored private citizen who was also a giant of a man. Drawing on sources previous biographers have glossed over or missed entirely, Burstein uncovers, first and foremost, how Jefferson confronted his own mortality; and in doing so, he reveals how he viewed his sexual choices. Delving into Jefferson's soul, Burstein lays bare the president's thoughts about his own legacy, his predictions for American democracy, and his feelings regarding women and religion. The result is a moving and surprising work of history that sets a new standard, post-DNA, for the next generation's reassessment of the most evocative and provocative of this country's founders.

Biochemical and Molecular Basis of Pediatric Disease, Fifth Edition has been a well-respected reference in the field for decades. This revision continues the strong focus on understanding the pathogenesis of pediatric disease, emphasizing not only the important role of the clinical laboratory in defining parameters that change with the disease process, but also the molecular basis of many pediatric diseases. Provides a fully-updated resource with more color illustrations Focuses on the biochemical and molecular basis of disease as well as the analytical techniques Defines important differences in the pathophysiology of diseases, comparing childhood with adult

In The Mind of Thomas Jefferson, one of the foremost historians of Jefferson and his time, Peter S. Onuf, offers a collection of essays that seeks to historicize one of our nation’s founding fathers. Challenging current attempts to appropriate Jefferson to serve all manner of contemporary political agendas, Onuf argues that historians must look at Jefferson’s language and life within the context of his own place and time. In this effort to restore Jefferson to his own world, Onuf reconnects that world to ours, providing a fresh look at the distinction between private and public aspects of his character that Jefferson himself took such pains to cultivate. Breaking through Jefferson’s alleged opacity as a person by collapsing the contemporary interpretive frameworks often used to diagnose his psychological and moral states, Onuf raises new questions about what was on Jefferson’s mind as he looked toward an uncertain future. Particularly striking is his argument that Jefferson’s character as a moralist is nowhere more evident, ironically, than in his engagement with the institution of slavery. At once reinvigorating the tension between past and present and offering a new way to view our connection to one of our nation’s founders, The Mind of Thomas Jefferson helps redefine both Jefferson and his time and American nationhood.

Sickle Cell Pain is a panoramic, in-depth exploration of every scientific, human, and social dimension of this cruel disease. This comprehensive, definitive work is unique in that it is the only book devoted to sickle cell pain, as opposed to general aspects of the disease. The 752-page book links sickle cell pain to basic, clinical, and translational research, addressing various aspects of sickle pain from molecular biology to the psychosocial aspects of the disease. Supplemented with patient narratives, case studies, and visual art, Sickle Cell Pain’s scientific rigor extends through its discussion of analgesic pharmacology, including abuse-deterrent formulations. The book also addresses in great detail inequities in access to care, stereotyping and stigmatization of patients, the implications of rapidly evolving models of care, and recent legislation and litigation and their consequences.

Hypercalcemia is the most common life-threatening metabolic disorder associated with cancer. The pathophysiological, epidemiological and clinical aspects of hypercalcemia of malignancy are presented in this issue, with a focus on the recently discovered humoral factor responsible for the development of hypercalcemia. With a better understanding of the pathophysiology of this condition and the development of new potent drugs, capable of inhibiting bone resorption, especially bisphosphonates, the clinician will be more successful in correcting hypercalcemia in the great majority of patients.