Lahita S Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disorder that can affect virtually any organ of the body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness or remission. Because its symptoms come and go and mimic those of other diseases, lupus is difficult to diagnose. There is no single laboratory test that can definitively prove that a person has the complex illness.To date, lupus has no known cause or cure. Early detection and treatment are the key to a better health outcome and can usually lessen the progression and severity of the disease. Anti-inflammatory drugs, antimalarials, and steroids (such as cortisone and others) are often used to treat lupus. Cytotoxic chemotherapies, like those used in the treatment of cancer, are also used to suppress the immune system in lupus patients. A new edition of this established and well-regarded reference combines basic science with clinical science to provide a translational medicine model. Systemic Lupus Erythematosus, Sixth Edition, is a useful reference for specialists in the diagnosis and management of patients with SLE, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease, and a reference work for hospital libraries. Completely updated, revised, and expanded with the most comprehensive and accessible reference on SLE for clinicians and scientists Full-color presentation throughout the book Provides the latest information available on diagnosis and treatment Incorporates an international panel of authors who are experts in their fields, with an emphasis on young, cutting-edge scientists and physicians

Systemic Lupus Erythematosus, Fourth Edition, provides an understanding of the basic mechanisms as well as the diagnostic and therapeutic aspects of lupus. Four-color illustrations throughout, this book is attractive to both the investigative community and clinicians. As lupus has become a paradigm for the study of autoimmune disease, immunologists investigating autoimmunity are becoming more interested in lupus. Basic immunology of phospholipid antibodies, clotting abnormailities, and newest methods of therapy of antiphospholipid syndrome are given in this newest edition of a classic reference. * Comprehensive current coverage of basic models of etiology and pathogenesis * Complete catalog of autoantibodies produced * Includes an outstanding review of imaging techniques for the diagnosis of lupus and its complications for each organ system * Includes CD-ROM of images excellent for teaching purposes and downloading into presentations

A revised and updated edition of the bestselling resource for lupus patients, their families, and medical professionals A perennial bestseller, Lupus Q&A is the go-to guide for sufferers of a chronic autoimmune disease that affects more than 1.4 million people in the United States alone. Characterized by achy joints and skin rashes, lupus often mimics other diseases, making it tricky to diagnose and treat. In this completely revised and updated edition, Dr. Robert Lahita and Dr. Robert Phillips—leading experts on lupus—discuss topics in a clear, concise, and easy-to-follow Q&A format. Lahita and Phillips review the newest drugs and explore beneficial complementary and alternative treatments, including new data on hormone use. Demystifying everything from diagnosis to the disease’s psychological impact, Lupus Q&A prepares readers to face the challenges ahead—and to restore their health and their lives.

A revised and updated edition of the bestselling resource for lupus patients, their families, and medical professionals A perennial bestseller, Lupus Q&A is the go-to guide for sufferers of a chronic autoimmune disease that affects more than 1.4 million people in the United States alone. Characterized by achy joints and skin rashes, lupus often mimics other diseases, making it tricky to diagnose and treat. In this completely revised and updated edition, Dr. Robert Lahita and Dr. Robert Phillips—leading experts on lupus—discuss topics in a clear, concise, and easy-to-follow Q&A format. Lahita and Phillips review the newest drugs and explore beneficial complementary and alternative treatments, including new data on hormone use. Demystifying everything from diagnosis to the disease’s psychological impact, Lupus Q&A prepares readers to face the challenges ahead—and to restore their health and their lives.

This volume brings together investigators working on the clinical problem of neuropsychiatric systemic lupus erythematosus, as well as neuroscientists from other disciplines. The presentations provide a current overview and access to a better understanding of cellular events in ischemia, the hypothalamic pituitary adrenal (HPA) axix and hypothalamic pituitary gonadal (HPG) axis changes in systemic inflammation, and the protective and toxic effects of glucocorticoids on the brain. The articles invoke discussion and generate future strategies for diagnosis and therapy.

This new companion to Hochberg et al.'s Rheumatology masterwork provides new insights into the causes, detection and therapy of this challenging disease. In this state-of-the-art resource, you'll find 'one stop' coverage of all the latest scientific and clinical developments in SLE: new concepts in epidemiology, disease activity measures and outcomes; new concepts in immunoregulation, genetic and pathogenic mechanisms; new understanding and novel presentation of the processes of tissue/organ damage; comprehensive coverage of clinical features; and the very latest concepts in treatment. Provides the very latest understanding of the pathogenesis of SLE. Distills current understanding of the cellular, molecular, genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features, including fatigue, organ system manifestations, overlap syndromes, infections, and more. Conveys the very latest understanding of mechanisms of tissue damage, including immune complexes, antibodies, and other mechanisms that lead to organ damage. Contains expert discussion of processes that are responsible for tissue injury - a hallmark of this text. Incorporates the latest treatment modalities, including steroids and non-steroidals, cytotoxic drug treatment, PAP's, and therapies on the horizon. Discusses the latest treatment options on disease modifying or disease controlling agents.

A rheumatologist and a psychologist offer an informative and compassionate perspective on coping with lupus for patients and their families. Lupus is a chronic autoimmune disease that is difficult to diagnose, and the symptoms-from achy joints to skin rashes-often mimic those of other diseases. Based on extensive research and clinical experience, Lupus Q&A answers the myriad questions of the more than 1.4 million lupus patients in this country. The book demystifies lupus by explaining diagnosis, symptoms, treatments, medication, and the psychological impact of the disease.

More than 140 years ago, lupus erythematosus (LE) was recognized as a disease entity by clinicians working in the field of dermatology, which had only recently become an independent medical discipline. Soon after cutaneous lupus was first reported, it was realized that, apart from the skin, the disease could involve other organs and thus be systemic in nature. The latter observations were first made by MORITZ KApOSI [1], whose work has attracted renewed attention re cently and who succeeded FERDINAND VON HEBRA to the chair of dermatology at the Medical Faculty in Vienna. The early description of lupus erythematosus in both its cutaneous and systemic manifes tations was thus intimately associated with Vienna and its Medical School. The next phase in the study of lupus was characterized by an in crease in knowledge of the type and extent of organ involvement. The work by OSLER [2], LIBMANN and SACKS [3], and KLEMPERER [4] best represents these advances. The increase in clinical knowledge of LE finally led to DUBOIS' famous monograph [5], which was pub lished at a time of renewed interest in SLE, elicited by the descrip tion by HARGRAVES et al. [6] of the LE-cell phenomenon. A more detailed analysis of this finding revealed that the disease was charac terized by an abnormal immune response, although its pathogenetic implications were still unclear.