Landmarks In Developmental Biology 1883 1924

Developmental biology took shape between 1880 and the 1920s Basic concepts like the developmental role of chromosomes and the germ plasm (today's genome), self differentiation, embryonic regulation and induction, gradients and organizers hail from that period; indeed, the discipline was defined as a whole by the programmatic writings of Wilhelm Roux as early as 1889. The present essays cover the period up to the Nobel prize-winning work of Hans Spemann and Hilde Mangold. They were originally published in Roux's Archives of Developmental Biology, from Vol. 200 onward to the journal's centennial issues in 1995/96. The essays aim at introducing current adepts of developmental biology to observations and experiments that have lead their predecessors towards basic concepts still influential today.

This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives. This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.

This volume provides a comprehensive reference for researchers aiming to bring new techniques and approaches to their scientific research using urodeles. Chapters are authored by leaders in the field and meant to guide readers through laboratory colony husbandry, traditional molecular techniques, experimental manipulation and surgeries, bioinformatics and genomics, transgenics and lineage-tracing, and physiological and organismal techniques. In addition to laboratory methods, this volume highlights techniques developed for field studies and work with wild-caught animals. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and state-of-the-art, Methods in Salamander Research aims to be a practical guide for researchers interested in deploying new methodologies in their lab or in the field.

This Open Access book combines philosophical and historical analysis of various forms of alternatives to mechanism and mechanistic explanation, focusing on the 19th century to the present. It addresses vitalism, organicism and responses to materialism and its relevance to current biological science. In doing so, it promotes dialogue and discussion about the historical and philosophical importance of vitalism and other non-mechanistic conceptions of life. It points towards the integration of genomic science into the broader history of biology. It details a broad engagement with a variety of nineteenth, twentieth and twenty-first century vitalisms and conceptions of life. In addition, it discusses important threads in the history of concepts in the United States and Europe, including charting new reception histories in eastern and south-eastern Europe. While vitalism, organicism and similar epistemologies are often the concern of specialists in the history and philosophy of biology and of historians of ideas, the range of the contributions as well as the geographical and temporal scope of the volume allows for it to appeal to the historian of science and the historian of biology generally.

Containing 609 encyclopedic articles written by more than 200 prominent scholars, The Oxford Companion to the History of Modern Science presents an unparalleled history of the field invaluable to anyone with an interest in the technology, ideas, discoveries, and learned institutions that have shaped our world over the past five centuries. Focusing on the period from the Renaissance to the early twenty-first century, the articles cover all disciplines (Biology, Alchemy, Behaviorism), historical periods (the Scientific Revolution, World War II, the Cold War), concepts (Hypothesis, Space and Time, Ether), and methodologies and philosophies (Observation and Experiment, Darwinism). Coverage is international, tracing the spread of science from its traditional centers and explaining how the prevailing knowledge of non-Western societies has modified or contributed to the dominant global science as it is currently understood. Revealing the interplay between science and the wider culture, the Companion includes entries on topics such as minority groups, art, religion, and science's practical applications. One hundred biographies of the most iconic historic figures, chosen for their contributions to science and the interest of their lives, are also included. Above all The Oxford Companion to the History of Modern Science is a companion to world history: modern in coverage, generous in breadth, and cosmopolitan in scope. The volume's utility is enhanced by a thematic outline of the entire contents, a thorough system of cross-referencing, and a detailed index that enables the reader to follow a specific line of inquiry along various threads from multiple starting points. Each essay has numerous suggestions for further reading, all of which favor literature that is accessible to the general reader, and a bibliographical essay provides a general overview of the scholarship in the field. Lastly, as a contribution to the visual appeal of the Companion, over 100 black-and-white illustrations and an eight-page color section capture the eye and spark the imagination.

Micro/Nanofluidics and Lab-on-Chip Based Emerging Technologies for Biomedical and Translational Research Applications - Part B, Volume 187 represents the collation of chapters written by eminent scientists worldwide. Chapters in this new release include Design and fabrication of microfluidics devices for molecular biology applications, Micro/Nanofluidics devices for drug delivery, From organ-on-chip to body-on-chip: the next generation of microfluidics platforms for in vitro drug toxicity testing, Micro/Nanofluidics for high throughput drug screening, Design, fabrication and assembly of lab-on-a-chip and its uses, Advances in microfluidic 3D cell culture for pre-clinical drug development, Tissue and organ culture on lab-on-a chip for biomedical applications, and much more. Offers a basic understanding of the state-of-the-art design and fabrication of microfluidics/ nanofluidics and lab on chip Explains how to develop microfluidics/nanofluidic for advanced application such as healthcare, high throughout drug screening, 3D cell culture and organ-on-chip Discusses the emerging demands and research of micro/nanofluidic based devices in biomedical and translational research applications

Development of the brain and the emergence of the mind constitute some of the most important concerns of contemporary biology. Disturbances during fetal life may have profound implications for a child's future neurological and psychological development, which can in turn impact society. The new edition of this highly respected work presents a comprehensive review of the basic mechanisms of brain development and the pathophysiology of disorders of the infant brain, written by a team of distinguished neuroscientists, neonatologists, and neuropediatricians. The book follows the main milestones of brain development, from formation of the neural tube and wiring of the neurons in the brain. Neurotrophic factors, neurotransmitters, glial cell biology, cerebral circulation development of sensory functions are all described in detail. Furthermore, there are more philosophical chapters on the evolution of the brain and the emergence of consciousness. Clinical considerations are highlighted where relevant.