Lead Compounds From Medicinal Plants For The Treatment Of Neurodegenerative Diseases

Lead Compounds from Medicinal Plants for the Treatment of Neurodegenerative Diseases is the second volume in the series, Pharmaceutical Leads from Medicinal Plants. This book includes key pharmacological and chemical evidence to support the selection of promising pre-clinical candidates for the treatment of neurodegenerative diseases. This important addition to the natural product and drug discovery literature contains the history, synonyms, medicinal uses, phytopharmacology, pre-clinical potential, and rationale for each plant selected. By providing critical evaluation of pharmacological data, mechanisms of action, and structural requirements for the development of future neuroprotective agents, this comprehensive reference is a beneficial resource for industry and academic scientists whose research focuses on neurodegenerative drug discovery and development. Incorporates compelling biological activity data and preclinical structure-activity relationships to help you choose promising lead molecules for further research Includes primary source references to the most recent natural product discoveries in the field of neuroprotection in order to promote new drug discovery in this area Contains detailed discussions of important neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Each plant section includes a critical evaluation of pharmacological, chemical, and toxicological evidence to support the use of the compound in drug discovery research in neurodegeneration

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Alzheimer's disease, one of the most rapidly growing neurodegenerative disorders, is characterized by a progressive loss of memory. Despite several advances in the field of medical therapeutics, a viable treatment for Alzheimer's disease would be of great importance. Medicinal plants represent a largely untapped reservoir of natural medicines and potential sources of anti-Alzheimer’s drugs. The structural diversity of their phytoconstituents makes these plants a valuable source of novel lead compounds in the quest for drugs to treat Alzheimer's disease. Based on traditional literature and up-to-date research, various new therapeutically active compounds have been identified from phytoextracts, which could be useful in the treatment of cognitive disorders. Phytomedicine and Alzheimer’s Disease presents information on Mechanistic aspects of neurodegeneration in Alzheimer’s disease and the role of phytochemicals as restorative agents Understanding the complex biochemical aspects of Alzheimer’s disease Pre-clinical approaches to evaluating drugs to target Alzheimer’s disease Assessing alternative approaches to treating Alzheimer’s disease and the role of alternative medicine to delay the symptomatic progression of this disease Epigenetic changes in Alzheimer’s disease and possible therapeutic or dietary interventions This book serves as an excellent resource for scientific investigators, academics, biochemists, botanists, and alternative medicine practitioners who work to advance the role of phytomedicines in treating Alzheimer’s disease.

Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways provides an unprecedented comprehensive overview of more than 100 plants used globally as medicine with the potential to prevent premature aging. This handbook covers the pathophysiology of aging from the molecular and cellular to the organ levels, as well as the current state of knowledge about the modes of action of natural products from plants on the pathophysiological pathways related to the (i) cardiovascular system and metabolism, (ii) central nervous system, (iii) kidneys, (iv) bones, (v) skin and hair, and (vi) immune system. Medicinal plants are presented alphabetically. For each plant is indicated the botanical family, synonyms, and common names in English, French, German, Portuguese, Russian, and Spanish. For each plant, the reader will also find the part used, active principles, medical history, contemporary medicinal uses, as well as pharmacological, clinical, and toxicological studies. The bibliographical references have been carefully selected for their relevance. This handbook is intended for medical doctors, nurses, pharmacists, dieticians, and nutritionists, as well as readers with interest in health food and herbs. FEATURES • Alphabetical presentation of over 100 medicinal plants and the pharmacological rationales for their uses for aging • Discusses the medical history, current medicinal uses, and potential candidates for the prevention of premature aging • Introduces the molecular mechanism of natural products on the pathophysiology of aging • Contains a selection of bibliographic references • A useful research tool for postgraduates, academics, and the pharmaceutical, herbal, or nutrition industries Handbook of Medicinal Plants of the World for Aging: Botany, Ethnopharmacology, Natural Products, and Molecular Pathways presents comment sections that invite further research and reflection on the fascinating and timely subject of herbals for healthy aging. This is an ideal reference text for medicinal plant enthusiasts.

Focuses on the effects of natural products and their active components on brain function and neurodegenerative disease prevention. Phytochemicals such as alkaloids, terpenes, flavanoids, isoflavones, saponins etc are known to possess protective activity against many neurological diseases. The molecular mechanisms behind the curative effects rely mainly on the action of phytonutrients on distinct signaling pathways associated with protein folding and neuro-inflammation. The diverse array of bioactive nutrients present in these natural products plays a pivotal role in prevention and cure of various neurodegenerative diseases, disorders, or insults, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, traumatic brain injury, and other neuronal dysfunctions. However, the use of these antioxidants in the management of neurodegenerative conditions has so far been not well understood. This is a comprehensive collection addressing the effects on the brain of natural products and edible items such as reservatrol, curcumin, gingerol, fruits, vegetables, nuts, and marine products.

Bioactive compounds are abundant in nature, particularly in plants, which have the capacity to synthesize phenolics, flavonoids, caffeine, carotenoids, and much more. Different bioactive compounds can change or alter the life process due to their different biological activities. This book examines bioactive compounds and their sources, structures, and potential uses in various industries, including pharmaceuticals, medicine, cosmetics, and food processing.

Focusing on the molecular mechanisms of powerful naturally occurring agents and their implication for drug discovery, this timely book presents an overview of the most recent research advances in the field of bioactive natural products and natural drug formulations to combat today's destructive diseases. To this extent, the authors discuss the most severe neurological disorders in our modern civilization, such as Alzheimer's, Parkinson's and Huntington's disease, as well as ischemic brain stroke and depression. The emerging diversity of active compounds is covered in detail, including flavonoids, cannabinoids and oleanolic acid, while experts in the field explain the chemistry, mode of action and clinical aspects of novel neuroprotective natural products. In each case, the benefits of treatments using natural products are addressed from the perspective of modern as well as traditional medicine. With its multidisciplinary viewpoint, this is the ideal companion for medicinal and natural products chemists as well as neuroscientists, biochemists, pharmacologists, neurobiologists, and phytotherapists.

This book covers the morphological characteristics, ethnopharmacological properties, isolated and identified structurally diverse secondary metabolites, biological and pharmacological activities of medicinal plants. Ethnopharmacology is the systematic study of folklore/traditional medicines, which continue to provide innovative drugs and lead molecules for the pharmaceutical industry. In fact, plant secondary metabolites, used as a single molecule or as a mixture, are medicines that can be effective and safe even when synthetic drugs fail. Therefore, the description of these secondary metabolites as well as methods for the targeted expression and/or purification is of high interest. In addition to surveying the morphological features, ethnopharmacological properties, biological and pharmacological activities, and studies of clinical trials, this book offers a comprehensive treatment of 56 plant species. It also presents the cell culture conditions and various methods used for increasing the production of medicinally important secondary metabolites in plant cell cultures. This volume: · Provides the morphological features, habitat, and distribution of each species of 56 genera selected from the different regions of the world. · Presents ethnopharmacological applications of various species of the 56 genera included in this book. Different species of 56 genera are used for ethnomedicinal uses by the people of various countries of the world. · Describes structures of various secondary metabolites identified in 56 plant species together with their biological and pharmacological activities. · Discusses strategies of secondary metabolites production, such as organ culture, pH, elicitation, hairy root cultures, light, and mutagenesis. · Provides a complete overview of each species of 56 genera and complete information up to 2022. Ethnopharmacological Properties, Biological Activity and Phytochemical Attributes of Medicinal Plants is an important book for undergraduate and postgraduate students, pharmacologists, phytochemists, Ayurvedic practitioners, medical doctors, and biotechnologists interested in the ethnopharmacological properties, phytochemistry, and biological and pharmacological activities of plants.