Loops And Grooves

General Reference

This book addresses the development of both DNA-sequence-selective and DNA-form-selective ligands, with the aim of creating potential molecular probes and therapeutic agents for non-canonical DNA structure-caused human diseases. Over the past two decades, the structural diversity of DNA forms has been proven to have profound implications in various biological, neurological, and pharmacological events. In response, researchers have since made tremendous efforts to obtain highly active drugs interacting with disease-related non-canonical DNA structures. These drugs, however, have not yet been approved for clinical use. One obstacle impeding their clinical application has to do with selectivity. This book focuses on secondary DNA structures formed by trinucleotide repeat sequences (“hairpin form”) or guanine-rich sequences (“G-quadruplex form”), both of which are pathological molecules for neurodegenerative diseases and/or cancer. Most importantly, it contends that a particular secondary structure of DNA in the context of the human genome can be targeted with a minimal affinity to other DNA structures by means ofcareful and rational ligand design. This approach opens an avenue to the development of highly selective drugs or diagnostic chemical tools for human diseases. Readers who want to know how synthetic ligands can be designed to selectively target a certain DNA molecule will find this book highly informative.

You’ve got the power. You don’t have to spend thousands of dollars on recording-studio time anymore. Now, using Pro Tools—a digital-audio workstation—you can record demos at home on your own computer, edit tracks, add effects, and even output songs to a CD. But if you’re new to working with sound digitally, you face a daunting learning curve. Getting your music gear to work with your desktop computer or laptop—and producing results that you like—involves some unfamiliar tools and concepts. At last, here’s a Pro Tools book written by a musician for other musicians! Author Gina Fant-Saez knows first-hand how frustrating it can be when you first make the move to using this complex, studio-quality audio application. Rather than overwhelm you with every detail of the program and complicated terminology or functions you’ll never use, Pro Tools for Musicians and Songwriters teaches only the essentials you need to record, enhance, and output your music. With downloadable audio files from www.protoolsformusicians.com to help you get started, Pro Tools for Musicians and Songwriters will show you how to: • Use a metronome (click track) or percussion loop to help you keep time when you record • Record and combine multiple takes to create one seamless composition • Edit your tracks with crossfades, panning, doubling, automation more[ • Add and manipulate plug-in effects, such as reverb • Share your Pro Tools files with other musicians around the globe • Output your finished composition to a CD

Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA). This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results. Completely updated, with an expanded section on protein-nucleic acid interactions that reflects major increases in our knowledge Defines technical terms for novices Includes a complete list of resources, including relevant online databases and software, as well as useful websites