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Cost-Effective Space Mission Operations, Second Edition describes the relationship between mission operations and the other elements of the space mission as well as specific operations tasks. This book defines a process that helps the mission operations manager translate mission objectives and requirements into a viable mission operations concept. The mission operations manager must develop this operations concept early enough, during concept exploration, so that the project manager can trade the future cost of operations against current development costs. Written for professionals and students involved in systems engineering and operations in space, this book is valuable for program managers, mission operations managers, spacecraft engineers and designers, project scientists and operators. Cost-Effective Space Mission Operations includes detailed descriptions of thirteen mission operations functions, provides a process for developing a mission operations concept, and describes a model for evaluating the cost and complexity of an operations system. The book also covers how to conduct routine, launch and early-orbit, and special operations, as well as how to operate interplanetary, international, microsatellite, and crewed missions.

"By far the single most important account and analysis of the Katrina catastrophe." David L. Clark, McMaster University In his newest provocative book, prominent social critic Henry A. Giroux shows how the tragedy and suffering in the aftermath of Hurricane Katrina signals a much larger crisis in the United States-one that threatens the very nature of individual freedom and inclusive democracy. This crisis extends far beyond matters of leadership, governance, or the Bush administration. It is a crisis that strikes at the very heart of democracy and must be understood within a broader set of antidemocratic forces that not only made the social disaster underlying Katrina possible, but also contribute to an emerging authoritarianism in the United States. Questions regarding who is going to die and who is going to live are driving a new form of authoritarianism in the United States. Within this form of "dirty democracy" a new and more insidious set of forces-embedded in our global economy-have largely given up on the sanctity of human life, rendering some groups as disposable and privileging others. Giroux offers up a vision of hope that creates the conditions for multiple collective and global struggles that refuse to use politics as an act of war and markets as the measure of democracy. Making human beings superfluous is the essence of totalitarianism, and democracy is the antidote in urgent need of being reclaimed. Katrina will keep the hope of such a struggle alive because for many of us the images of those floating bodies serve as a desperate reminder of what it means when justice, as the lifeblood of democracy, becomes cold and indifferent.

Hepatocytes account for approximately 80% of the liver mass and play a significant role in various aspects of liver physiopathology, exhibiting unrivaled complexity and diversity of functions. In Hepatocytes: Methods and Protocols, expert researchers provide the reader with methods, technical protocols, and review chapters focusing on selected areas of hepatocyte biology including isolation, culture, differentiation and stem cells, and hepatocyte use in clinical, basic, and applied research. With a specific emphasis on human hepatocytes, the volume presents chapters covering subjects including hepatocyte culture models, cryopreservation methods, differentiation assessment, liver ontogenesis, production of hepatocytes from stem cells, drug/xenobiotic metabolism, toxicity and transport, bile acid and blood coagulation factor production, infection by HBV and HCV, humanized animals, biortificial liver devices, hepatocyte transplantation. As a volume in the highly successful Methods in Molecular BiologyTM series, protocol chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Hepatocytes: Methods and Protocols will be useful to all those who are currently using or planning to use human, or animal, hepatocytes to investigate any aspect of liver physiopathology or who are interested in liver development or liver stem cells and liver biotherapy.