Major Methods Of Peptide Bond Formation

The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

The Peptides, Volume I: Methods of Peptide Synthesis focuses on detailed description of protecting groups, individual amino acids, and coupling reactions. The publication first offers information on amino-protecting and carboxyl-protecting groups, including carboxyl protection by salt formation, esterification, and amide formation and acyl-type, alkyl-type, and urethane protecting groups. The text then examines the formation of the peptide bond and amino acids. Discussions focus on amino acids with the alcoholic hydroxyl group, sulfur amino acids, basic and acidic amino acids, synthesis of peptides by activation of the amino group, and peptide synthesis by activation of the carboxyl group. The manuscript elaborates on the synthesis of cyclic peptides, depsipeptides, peptoids, and the plastein reaction. Topics include synthesis of plastein-active peptides, glycopeptides, phosphopeptides, and S-peptides. The publication is a dependable source of data for readers interested in the methods of peptide synthesis.

This book focuses on the chemical principles behind the more important methods of peptide synthesis, and it provides a critical, concise, and up-to-date survey of the field.

The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volumehas been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. More than 275 volumes have been published (all of them still in print) and much of the material is relevant even today-truly an essential publication for researchers in all fields of life sciences. Key Features * Solid-phase peptide synthesis * Applications of peptides for structural and biological studies * Characterization of synthetic peptides