Memory S Wake

This volume connects current ideas and concepts about sleep functions and circadian rhythms with the search for novel target-selective sleep-wake therapeutics. To do so, it provides a timely, state-of-the-art overview of sleep-wake mechanisms in health and disease, ongoing developments in drug discovery, and their prospects for the clinical treatment of sleep-disordered patients. It particularly focuses on the concept that sleep and wakefulness mutually affect each other, and the future therapeutic interventions with either sleep- or wake-promoting agents that are expected to not only improve the quality of sleep but also the waking behavior, cognition, mood and other sleep-associated physiological functions. The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at link.springer.com

The Behavioral, Molecular, Pharmacological, and Clinical Basis of the Sleep-Wake Cycle provides the first comprehensive overview on the molecular methodologies used to evaluate sleep while also examining the cellular, biochemical, genetic, and therapeutic aspects of the sleep-wake cycle. There have been profound changes in the landscape of approaches to the study of sleep – mainly in the areas of molecular biology and molecular techniques. With this great focus on using multidisciplinary molecular methods, chapters address significant advances in the molecular mechanisms underlying sleep and the techniques researchers use to study this phenomenon. Written by world-leading experts in the area, this book is of great interest to researchers working in the sleep field and to anyone interested in one of the most mysterious phenomena in science – why we sleep and why we cannot survive without it. Reviews the neurobiological and cellular mechanisms of the sleep-wake cycle Provides the implications of sleep in health and disease Contrasts different techniques to study molecular mechanisms Contains case studies to better illustrate points Covers sleep disturbance and health problems involved in sleep Includes chapters on the ontogeny of sleep, along with multiple mechanisms for sleep generation

Laypeople think of wake, sleep and dreaming as distinct states of the mind/brain but “in-between”, hybrid states are recognized. For example, day-dreaming or, more scientifically, the default network occurs during wake. Equally, during sleep, lucid dreaming in rapid eye movement (REM) sleep presents as another hybrid state. But hybrid states are usually temporary. This book explores the possibility of an enduring hybrid wake-sleep-dream state, proposing that such a state may engender both creativity and psychopathologies. REM sleep is hyper-associative. Creativity depends on making remote associations. If REM sleep and dreaming begin to suffuse the wake state, enhanced creativity may result. But moderate to severe interpenetration of wake, sleep and dreaming may engender psychopathologies – as the functions of wake, sleep and dreaming are partially eroded.

She doesn't belong in this fairy tale land. 'Memory' is having a bad day. Torn through a magical portal. Her past unknown, stolen. She has no idea how much worse things will get. The only thing she knows is she has to run. A dragon hunts her. The fairies despise her. The king wants her soul. And a wild man follows her in the shadows… Memory will do anything to get back home, wherever that is, but unexplainable forces and dangerous secrets push her toward a fate darker than she ever imagined. Will she survive learning the truth? Victorian style, fairy tale creatures, and Arthurian lore combine in this unforgettable tale. Memory's Wake is the first book in this complete young adult fantasy trilogy, perfect for readers seeking a unique story full of intrigue, unexpected twists and high-stakes action. Get your copy of this spellbinding page-turner today.

Dreams play a significant role in our life, meaningfully affecting us in the development of our personality and our spiritual journey. They are an everyday experience for any human being. Dreams have always been of great interest to poets and philosophers alike since ancient times and examples are aplenty in Indian and Western scriptures. However, it is an uphill task for an ordinary person to fully appreciate the intricacies and significance of dreams in the day-to-day life. It is here that this book proves as an invaluable guide providing deep understanding on the nature of dream and sleep. This book is a repertoire of human wisdom – gathered for centuries and attested by the modern science – offering enormous insights into our dream and deep-sleep states. It asks, from a common man’s point of view, many a question that perturb us and provides answers to them from the scientific and spiritual perspectives in a captivating way. Some such questions include: • Do we see dreams in black and white or in colour? • What does a visually-challenged person see in his dreams? • Why are some of our dreams extraordinarily vivid with electric colours, the clarity and brilliance of which, we may never encounter in our ordinary waking lives? • Why are we non-reflective, irrational in our dreams? • Are the dream time and waking time equal? • How does our memory work in dream state? Why do we forget our dreams and is it possible to improve dream recall and cultivate awareness in dreams? • Why do we fail to distinguish a dream object from the physical world object while we are dreaming? • If the dream experience exactly feels like the real world and we fail to distinguish it from the waking world while we are dreaming, how can we be certain that we are not dreaming now? • How does a dream contain various persons exhibiting opposite emotions at the same time when all the dream characters including the witnessing dreamer are produced out of single mind of the dreaming person? • Can we intentionally transform the dream scenarios? If so, what would be the philosophical implications of it? • Can dreams and sleeps be utilized for spiritual elevation? ... and many more questions we always wondered about the daily eight hours of our bed time, but never got the right answers to! We find new meanings and ways in dealing with our dreams in this volume, therefore, it is a must read for every dream enthusiast as well as any serious spiritual seeker.

It turns out that many of the things our fathers teach us by word and action are truths more profound than we can imagine. It is often after we struggle to make our own way in the world, thinking we do not need our father's advice, that we realize that we have become our father. We discover ourselves saying things to our children that our father's said to us. If we think deeply about this phenomenon we notice that the words of our fathers reflect profound universal truths. Our fathers perhaps did not even know why they said these things to us. We often do not even now why we say these things. They just sound right. It is a Voice that arises within us and there is a resonance in the saying of them. We feel connected not only with our fathers but with universal Father. We have the feeling of entering the sacred.

"The meaning of life is the most urgent of questions," said the existentiallist thinker Albert Camus. And no less a philosopher than Woody Allen has wondered:"How is it possible to find meaning in a finite world, given my waist and shirt size?" "Movies and the Meaning of Life" looks at popular and cult movies, examining their assumptions and insights on meaning-of-life questions: What is reality and how can I know it? (The Truman Show, Contact, Waking Life); How do I find myself and my true identity? (Fight Club, Being John Malkovich, Boys Don't Cry, Memento); How do I find meaning from my interactions with others? (Pulp Fiction, Shadowlands, Chasing Amy); What is the chief purpose in life? (American Beauty, Life is Beautiful, The Shawshank Redemption); and How ought I live my life? (Pleasantville, Spiderman, Minority Report, Groundhog Day).