Metabolic Maps Of Pesticides

Metabolic Maps of Pesticides, Volume 2, provides a summary of investigations and drawings of the metabolic patterns on pesticides that drawn from references published from 1985-1986 concerning metabolic fates in mammalian, plant, bird, soil, microorganism systems; by physicochemical reactions such as hydrolysis, photolysis, and thermal degradation; or studies in model systems. Metabolic maps are provided for the following: acid amides, amidines and guanidines, anilines and nitrobenzenes, biphenyl ethers, DDT and its analogs, dithio- and thiolcarbamates, five- and six-membered heterocyclic compounds, imides, organochlorine compounds, oxime carbamates, phenoxyacetic acids, pheny ring fused five-membered heterocyclic compounds, phenyl(aryl) carbamates, phenylureas and related compounds, phosphonothiolates and phosphonothioates, phosphonates, phosphorothioamides, phosphates, phosphorothiolates, pyrethroids, pyridines, triazines, and substituted benzenes and miscellaneous compounds. This volume includes a Pesticide Activity Index to understand the biological activity of individual pesticides. These metabolic maps are useful not only to chemists and biochemists working in industries that supply new and improved pesticides worldwide but also to toxicologists and others interested in the biomedical field.

This important publication provides a comprehensive summary of data and information on the metabolism and chemical degradation of agrochemicals in soils, plants and animals. Part 1, Herbicides and Plant Growth Regulators, and Part 2, Insecticides and Fungicides, together provide a major bibliography, as each entry is fully referenced. Contents include metabolic products, pathways and mechanisms, together with useful details on physico-chemical properties and mode of action. Both parts are organised by class of chemical for easy reference. There are separate entries for each pesticide, covering most commercially available chemicals in use today. In addition, an overview of the metabolism of each major class provides the reader with an informed summary of key similarities and significant differences between individual chemicals. Information is based primarily on literature from the past 40 years of research, together with some important, previously unpublished work provided by the agrochemical companies. Presented in a systematic, easy-to-read style, with extensive indexing to facilitate the rapid location of required information and the comparison of related compounds, Metabolic Pathways of Agrochemicals is an invaluable reference for chemists, biochemists and biologists working in the discovery, development and registration of agrochemicals, as well as scientists in related areas such as design and mode of action of pharmaceuticals.

People working in development of drugs, pesticides, washing detergents, etc., are obliged by law to conduct analyses of the "metabolic pathways" or "maps" for the chemical compounds that they are using or proposing. Everyone in these industries or carrying out research toward such products is therefore interested in having a reference on these compounds. Covers literature relating to degradation and metabolic profiles of molecules Draws together the literature on degradation and metabolism patterns with that on diversified conditions of the environmental systems Indicates 3D chemical structures, predicted physico-chemical parameters, logP and the SMILES chemical notations of the parent compounds to assist scientists design the lead compounds for new discovery using computer-aided technology

This important publication provides a comprehensive summary of data and information on the metabolism and chemical degradation of agrochemicals in soils, plants and animals. Part 1, Herbicides and Plant Growth Regulators, and Part 2, Insecticides and Fungicides, together provide a major bibliography, as each entry is fully referenced. Contents include metabolic products, pathways and mechanisms, together with useful details on physico-chemical properties and mode of action. Both parts are organised by class of chemical for easy reference. There are separate entries for each pesticide, covering most commercially available chemicals in use today. In addition, an overview of the metabolism of each major class provides the reader with an informed summary of key similarities and significant differences between individual chemicals. Information is based primarily on literature from the past 40 years of research, together with some important, previously unpublished work provided by the agrochemical companies. Presented in a systematic, easy-to-read style, with extensive indexing to facilitate the rapid location of required information and the comparison of related compounds, Metabolic Pathways of Agrochemicals is an invaluable reference for chemists, biochemists and biologists working in the discovery, development and registration of agrochemicals, as well as scientists in related areas such as design and mode of action of pharmaceuticals.

This important publication provides a comprehensive summary of data and information on the metabolism and chemical degradation of agrochemicals in soils, plants and animals. Part 1, Herbicides and Plant Growth Regulators, and Part 2, Insecticides and Fungicides, together provide a major bibliography, as each entry is fully referenced. Contents include metabolic products, pathways and mechanisms, together with useful details on physico-chemical properties and mode of action. Both parts are organised by class of chemical for easy reference. There are separate entries for each pesticide, covering most commercially available chemicals in use today. In addition, an overview of the metabolism of each major class provides the reader with an informed summary of key similarities and significant differences between individual chemicals. Information is based primarily on literature from the past 40 years of research, together with some important, previously unpublished work provided by the agrochemical companies. Presented in a systematic, easy-to-read style, with extensive indexing to facilitate the rapid location of required information and the comparison of related compounds, Metabolic Pathways of Agrochemicals is an invaluable reference for chemists, biochemists and biologists working in the discovery, development and registration of agrochemicals, as well as scientists in related areas such as design and mode of action of pharmaceuticals.

Metabolic Maps of Pesticides provides a summary of investigations and drawings of the metabolic patterns on pesticides that were collected with the aid of Chemical Abstracts Service (CAS) for the years 1970-1979. Some maps were taken from the original reports, some were slightly modified for clarity, and some were tentatively drawn from descriptions in the original articles. The pesticides are classified based on their chemical structures as functional groups or based on common chemical nomenclature. The chemical classifications highlight the properties of the mother pesticides and the impact of their degenerative metabolites on the environment. Metabolic maps are provided for the following: acid amides, amidines and guanidines, anilines and nitrobenzenes, biphenyl ethers, DDT and its analogs, dithio- and thiolcarbamates, five- and six-membered heterocyclic compounds, imides, organochlorine compounds, oxime carbamates, phenoxyacetic acids, pheny ring fused five-membered heterocyclic compounds, phenyl(aryl) carbamates, phenylureas and related compounds, phosphonothiolates and phosphonothioates, phosphonates, phosphorothioamides, phosphates, phosphorothiolates, pyrethroids, pyridines, triazines, and substituted benzenes and miscellaneous compounds.

Disappearance of pesticides takes place by leaching, volatilization, adsorption, decompositino, or metabolism; and the use to which a particular pesticide is best suited may depend on the effects of one or more of these processes.

This publication supplements the preceding Metabolism of Pesticides (1969) and Metabolism of Pesticides - An Update (1974). Readers are also advised that, during the period from preparation to printing of this volume, a considerable additional literature on this subject matter has been published.