Metabolite And Nutrient Transporters In Cancer Cell Metabolism Role In Cancer Progression And Metastasis
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Metabolite and Nutrient Transporters in Cancer Cell Metabolism Role in Cancer Progression and Metastasis
Author | : Vadivel Ganapathy,Maria E. Mycielska,Eric Kenneth Parkinson,Sebastian Haferkamp |
Publsiher | : Frontiers Media SA |
Total Pages | : 154 |
Release | : 2022-08-12 |
Genre | : Science |
ISBN | : 9782889767687 |
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The Heterogeneity of Cancer Metabolism
Author | : Anne Le |
Publsiher | : Springer |
Total Pages | : 186 |
Release | : 2018-06-26 |
Genre | : Medical |
ISBN | : 9783319777368 |
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Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment
Author | : Yongsheng Li,Bo Zhu |
Publsiher | : Frontiers Media SA |
Total Pages | : 87 |
Release | : 2019-03-20 |
Genre | : Electronic Book |
ISBN | : 9782889457854 |
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Metabolism of glucose, lipids, amino acids, and nucleotides represents the fundamental capability of host to utilize distinct nutrients and energy to support diverse function of different cell lineages. Cancer cells undergo the Warburg Effect to adapt to the microenvironment composed by stromal cells and immune cells. The crosstalk among cancer cells and immune cells orchestrate tumor progression. In the tumor microenvironment, immune cells also show metabolic reprogramming. For example, naive or memory T cells switch from the oxidation of fatty acids to glycolysis and glutaminolysis after activation; meanwhile massive glucose and glutamine are transported into cells to meet their metabolic demands. Defective glucose or glutamine metabolism impairs the differentiation and expansion of helper T cells. The molecular pathways that control immune cell metabolism and function are intimately linked. Understanding such metabolic reprogramming of immune cells in the tumor microenvironment could offer new directions in manipulation of peripheral immune responses. Recent findings in immune cell metabolism hold the promising possibilities by metabolic manipulation of immune cells towards clinical therapeutics for treating cancer. This Research Topic includes updated findings and views in the metabolism of cancer cells and immune cells in the tumor microenvironment.
Immuno Oncology Crosstalk and Metabolism
Author | : Muzafar Ahmad Macha,Ajaz Ahmad Bhat,Nissar Ahmad Wani |
Publsiher | : Springer Nature |
Total Pages | : 223 |
Release | : 2022-05-16 |
Genre | : Medical |
ISBN | : 9789811662263 |
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This book discusses the novel metabolic cross-talk between immune and tumor cells in the tumor microenvironment that promotes their growth and progression. It also describes deregulated metabolism in cancer cells that promotes suppressive and cancer cell-favourable microenvironment. Further, the book provides novel insights on the metabolic changes in immune cells that promote tumor cell growth and survival. In turn, it also reviews the involvement of immuno-onco metabolic cross-talk in the development of resistance to chemo-radiation therapy (CRT) in tumor cells. Lastly, it also explores the potential of immuno-oncology metabolism as a therapeutic approach against tumor cells.
Metabolism Meets Function Untangling the Cross Talk Between Signalling and Metabolism
Author | : Alessandra Castegna,Paolo E. Porporato,Daniel McVicar |
Publsiher | : Frontiers Media SA |
Total Pages | : 231 |
Release | : 2020-12-18 |
Genre | : Medical |
ISBN | : 9782889662623 |
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Metabolism in Cancer
Author | : Thorsten Cramer,Clemens A. Schmitt |
Publsiher | : Springer |
Total Pages | : 272 |
Release | : 2016-08-24 |
Genre | : Medical |
ISBN | : 9783319421186 |
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This textbook presents concise chapters written by internationally respected experts on various important aspects of cancer-associated metabolism, offering a comprehensive overview of the central features of this exciting research field. The discovery that tumor cells display characteristic alterations of metabolic pathways has significantly changed our understanding of cancer: while the first description of tumor-specific changes in cellular energetics was published more than 90 years ago, the causal significance of this observation for the pathogenesis of cancer was only discovered in the post-genome era. The first 10 years of the twenty-first century were characterized by rapid advances in our grasp of the functional role of cancer-specific metabolism as well as the underlying molecular pathways. Various unanticipated interrelations between metabolic alterations and cancer-driving pathways were identified and currently await translation into diagnostic and therapeutic applications. Yet the speed, quantity, and complexity of these new discoveries make it difficult for researchers to keep up to date with the latest developments, an issue this book helps to remedy.
Cancer Cell Metabolism A Potential Target for Cancer Therapy
Author | : Dhruv Kumar |
Publsiher | : Springer Nature |
Total Pages | : 191 |
Release | : 2020-02-13 |
Genre | : Medical |
ISBN | : 9789811519918 |
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This book illustrates various aspects of cancer cell metabolism, including metabolic regulation in solid tumours vs. non-solid tumours, the molecular pathways involved in its metabolism, and the role of the tumour microenvironment in the regulation of cancer cell metabolism. It summarizes the complexity of cancer cell metabolism in terms of the switch from anaerobic to aerobic glycolysis and how mitochondrial damage promotes aerobic glycolysis in cancer cells. The respective chapters provide the latest information on the metabolic remodelling of cancer cells and elucidate the important role of the signalling pathways in reprogramming of cancer cell metabolism. In addition, the book highlights the role of autophagy in cancer cell metabolism, and how metabolic crosstalk between cancer cells and cancer-associated fibroblasts promotes cancer cell progression. In closing, it summarizes recent advancements in drug development through targeting cancer metabolism.
The Tumour Microenvironment
Author | : Jamie A. Goode,Derek J. Chadwick |
Publsiher | : John Wiley & Sons |
Total Pages | : 322 |
Release | : 2001-11-28 |
Genre | : Science |
ISBN | : 0471499595 |
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Ergebnisse von in vitro-Studien lassen vermuten, dass sich der pH-Wert in einem Tumor auf die Wirksamkeit von Chemo- oder Strahlentherapien auswirken kann. Wie aber sieht die Beziehung zwischen der Tumorentwicklung und dem pH-Wert aus? Können ein niedriger pH-Wert oder ein Sauerstoffmangel die Carcinogenese hemmen? Wo bieten sich therapeutische Ansätze? Anwort auf diese und andere Fragen finden Sie in diesem Band. In interdisziplinärer Weise wurden Beiträge aus der Grundlagenforschung und der klinischen Praxis zusammengetragen.