Mobile Genetic Elements In Cellular Differentiation Genome Stability And Cancer
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Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer
Author | : Tammy A. Morrish,Jose Luis García Pérez |
Publsiher | : Frontiers Media SA |
Total Pages | : 123 |
Release | : 2018-01-16 |
Genre | : Electronic Book |
ISBN | : 9782889453894 |
Download Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer Book in PDF, Epub and Kindle
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a “copy and paste” mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS). To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer
![Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Anonim |
Publsiher | : Unknown |
Total Pages | : 0 |
Release | : 2018 |
Genre | : Electronic Book |
ISBN | : OCLC:1368439880 |
Download Mobile Genetic Elements in Cellular Differentiation Genome Stability and Cancer Book in PDF, Epub and Kindle
The human genome, as with the genome of most organisms, is comprised of various types of mobile genetic element derived repeats. Mobile genetic elements that mobilize by an RNA intermediate, include both autonomous and non-autonomous retrotransposons, and mobilize by a "copy and paste" mechanism that relies of the presence of a functional reverse transcriptase activity. The extent to which these different types of elements are actively mobilizing varies among organisms, as revealed with the advent of Next Generation DNA sequencing (NGS).To understand the normal and aberrant mechanisms that impact the mobility of these elements requires a more extensive understanding of how these elements interact with molecular pathways of the cell, including DNA repair, recombination and chromatin. In addition, epigenetic based-mechanisms can also influence the mobility of these elements, likely by transcriptional activation or repression in certain cell types. Studies regarding how mobile genetic elements interface and evolve with these pathways will rely on genomic studies from various model organisms. In addition, the mechanistic details of how these elements are regulated will continue to be elucidated with the use of genetic, biochemical, molecular, cellular, and bioinformatic approaches. Remarkably, the current understanding regarding the biology of these elements in the human genome, suggests these elements may impact developmental biology, including cellular differentiation, neuronal development, and immune function. Thus, aberrant changes in these molecular pathways may also impact disease, including neuronal degeneration, autoimmunity, and cancer.
Genetics Cell Differentiation and Cancer
Author | : Paul A. Marks |
Publsiher | : Unknown |
Total Pages | : 248 |
Release | : 1985 |
Genre | : Medical |
ISBN | : UOM:39015010677725 |
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Systems Biology of Cancer
Author | : Sam Thiagalingam |
Publsiher | : Cambridge University Press |
Total Pages | : 597 |
Release | : 2015-04-09 |
Genre | : Mathematics |
ISBN | : 9780521493390 |
Download Systems Biology of Cancer Book in PDF, Epub and Kindle
An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.
Mobile Genetic Elements
Author | : James Alan Shapiro,James Allen Shapiro |
Publsiher | : Unknown |
Total Pages | : 714 |
Release | : 1983 |
Genre | : Science |
ISBN | : UOM:39015004416189 |
Download Mobile Genetic Elements Book in PDF, Epub and Kindle
Mobile Genetic Elements introduces the nonspecialist to the biology and genetics of mobile elements. It attempts to make the biochemistry of DNA rearrangements more accessible to embryologists and evolutionists, and to illuminate the related developmental cycles to the biochemist. The book also shows how natural the activity of mobile elements can be in diverse biological situations. The chapters describe several well-studied cases in which genetic determinants-often identified as specific nucleic acid sequences-repeatedly change their positions within or between cellular genomes. Because thei ...
Molecular Biology of The Cell
Author | : Bruce Alberts |
Publsiher | : Unknown |
Total Pages | : 0 |
Release | : 2002 |
Genre | : Cytology |
ISBN | : 0815332181 |
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Comparative Oncology
![Comparative Oncology](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Alecsandru Ioan Baba,Cornel Cătoi |
Publsiher | : Unknown |
Total Pages | : 787 |
Release | : 2007 |
Genre | : Electronic books |
ISBN | : 9732714573 |
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The Maize Genome
Author | : Jeffrey Bennetzen,Sherry Flint-Garcia,Candice Hirsch,Roberto Tuberosa |
Publsiher | : Springer |
Total Pages | : 390 |
Release | : 2018-11-24 |
Genre | : Science |
ISBN | : 9783319974279 |
Download The Maize Genome Book in PDF, Epub and Kindle
This book discusses advances in our understanding of the structure and function of the maize genome since publication of the original B73 reference genome in 2009, and the progress in translating this knowledge into basic biology and trait improvement. Maize is an extremely important crop, providing a large proportion of the world’s human caloric intake and animal feed, and serving as a model species for basic and applied research. The exceptionally high level of genetic diversity within maize presents opportunities and challenges in all aspects of maize genetics, from sequencing and genotyping to linking genotypes to phenotypes. Topics covered in this timely book range from (i) genome sequencing and genotyping techniques, (ii) genome features such as centromeres and epigenetic regulation, (iii) tools and resources available for trait genomics, to (iv) applications of allele mining and genomics-assisted breeding. This book is a valuable resource for researchers and students interested in maize genetics and genomics.