Modeling Human Atrial Patho Electrophysiology From Ion Channels To Ecg Substrates Pharmacology Vulnerability And P Waves
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Modeling Human Atrial Patho Electrophysiology from Ion Channels to ECG Substrates Pharmacology Vulnerability and P Waves
Author | : Loewe, Axel |
Publsiher | : KIT Scientific Publishing |
Total Pages | : 344 |
Release | : 2016-08-03 |
Genre | : Electronic Book |
ISBN | : 9783731505280 |
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Modeling Human Atrial Patho Electrophysiology From Ion Channels to ECG Substrates Pharmacology Vulnerability and P Waves
Author | : Axel Loewe |
Publsiher | : Unknown |
Total Pages | : 334 |
Release | : 2020-10-09 |
Genre | : Medical |
ISBN | : 1013283872 |
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Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.
Cardiac Modeling Aiming for Optimization of Therapy
Author | : Javier Saiz,Olaf Doessel |
Publsiher | : Frontiers Media SA |
Total Pages | : 248 |
Release | : 2020-12-15 |
Genre | : Science |
ISBN | : 9782889662197 |
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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Multiscale Cohort Modeling of Atrial Electrophysiology Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms
Author | : Nagel, Claudia |
Publsiher | : KIT Scientific Publishing |
Total Pages | : 280 |
Release | : 2023-04-24 |
Genre | : Electronic Book |
ISBN | : 9783731512813 |
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An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.
Characterizing Cardiac Electrophysiology during Radiofrequency Ablation An Integrative Ex vivo In silico and In vivo Approach
Author | : Pollnow, Stefan |
Publsiher | : KIT Scientific Publishing |
Total Pages | : 296 |
Release | : 2019-04-23 |
Genre | : Electronic Book |
ISBN | : 9783731508861 |
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A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation A Translational Study to Guide Ablation Therapy
Author | : Sánchez Arciniegas, Jorge Patricio |
Publsiher | : KIT Scientific Publishing |
Total Pages | : 162 |
Release | : 2022-05-30 |
Genre | : Medical |
ISBN | : 9783731511700 |
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The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.
Multiscale Modeling of Cardiac Electrophysiology Adaptation to Atrial and Ventricular Rhythm Disorders and Pharmacological Treatment
Author | : Mathias Wilhelms |
Publsiher | : KIT Scientific Publishing |
Total Pages | : 206 |
Release | : 2014-05-22 |
Genre | : Technology & Engineering |
ISBN | : 9783731500452 |
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Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.AbstractEnglisch = Multiscale modeling of cardiac electrophysiology helps to better understand the underlying mechanisms of atrial fibrillation, acute cardiac ischemia and pharmacological treatment. For this purpose, measurement data reflecting these conditions have to be integrated into models of cardiac electrophysiology. Several methods for this model adaptation are introduced in this thesis. The resulting effects are investigated in multiscale simulations ranging from the ion channel up to the body surface.
Cardiac Electrophysiology Methods and Models
Author | : Daniel C. Sigg,Paul A. Iaizzo,Yong-Fu Xiao,Bin He |
Publsiher | : Springer Science & Business Media |
Total Pages | : 490 |
Release | : 2010-09-11 |
Genre | : Medical |
ISBN | : 9781441966582 |
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Cardiovascular disease is the major cause of mortality and morbidity in the Western Hemisphere. While significant progress has been made in treating a major sub-category of cardiac disease, arrhythmias, significant unmet needs remain. In particular, every day, thousands of patients die because of arrhythmias in the US alone, and atrial fibrillation is the most common arrhythmia affecting millions of patients in the US alone at a given time. Therefore, there is a public need to continue to develop new and better therapies for arrhythmias. Accordingly, an ever increasing number of biomedical, pharmaceutical, and medical personnel is interested in studying various aspects of arrhythmias at a basic, translational, and applied level, both in industry (ie Biotech, Pharmaceutical and device), and in academia. Not only has our overall understanding of molecular bases of disease dramatically increased, but so has the number of available and emerging molecular, pharmacological or device treatment based therapies. This practical, state-of-the art handbook will summarize and review key research methods and protocols, their advantages and pitfalls, with a focus on practical implementation, and collaborative cross-functional research. The volume will include visual and easy-to-use graphics, bulleted summaries, boxed summary paragraphs, links to reference websites, equipment manufacturers where appropriate, photographs of typical experimental setups and so forth, to keep this book very focused on practical methods and implementation, and yet, provide enough theory that the principles are clearly understood and can be easily applied.