Mr Imaging In White Matter Diseases Of The Brain And Spinal Cord

In recent decades, the use of neuroimaging techniques has resulted in outstanding progress in the diagnosis and management of neurological diseases, and this is particularly true of those diseases that affect the white matter of the brain and spinal cord. This book, written by internationally acclaimed experts, comprises a series of comprehensive and up-to-date reviews on the use of MR imaging in these major neurological conditions. The diverse available MR techniques, such as magnetization transfer MRI, diffusion-weighted MRI, MR spectroscopy, functional MRI, cell-specific MRI, perfusion MRI, and microscopic imaging with ultra-high field MRI, offer an extraordinarily powerful means of gaining fundamental in vivo insights into disease processes. The strengths and weaknesses of all these techniques in the study of multiple sclerosis and other relevant diseases are extensively considered. After an introductory section on neuroimaging technology, subsequent sections address disorders of myelination, demyelinating diseases, immune-mediated disorders, and white matter disorders related to aging and other conditions. This book provides a valuable summary of the state of the art in the field, and defines important areas for future research.

For more than 25 years, Magnetic Resonance Imaging of the Brain and Spine has been the leading textbook on imaging diagnosis of brain and spine disorders. The Fifth Edition continues this tradition of excellence with thorough coverage of recent trends and changes in the clinical diagnosis and treatment of CNS diseases, and how those changes relate to MRI findings. It remains a comprehensive, state-of-the-art reference for all who have an interest in neuroradiology – trainees to experts in the field, basic science researchers, and clinicians.

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Magnetic resonance (MR) imaging and spectroscopy are powerful tools for demonstrating and monitoring pathological processes of the brain and spinal cord. Multiple sclerosis (MS), a common and as yet incurable disease of the brain and spinal cord, is being studied intensively using these techniques. They perform a major role in facilitating the diagnosis, understanding the mechanisms of symptoms, and monitoring the effect of new treatments. Written by experts in the field, this extensively illustrated text provides a comprehensive review of the benefits and limitations of MR in the study of MS. Coverage ranges through the contributions of MR, the variety of techniques available, diagnosis and differential diagnosis, MR as a predictor of the clinical course, MR views of pathophysiology, and finally monitoring new treatment efficacy.

White matter lesions have been always challenging for general as well as neuroradiologits. Any disease process in the brain or body can affect white matter, making it very difficult to pinpoint the diagnosis. However the application of the proper algorithmic approach, pattern of distribution, and study of the morphology of these lesions makes it possible to limit the differential diagnosis and, many times, pinpoint specific diagnosis. Advancement of various imaging techniques predominately in MR (MR spectroscopy, MR perfusion, diffusion tensor imaging (DTI). functional MR) along with PET has further improved our understanding of these disease processes. However, most of these techniques are new and not well understood by every physician. This issue will cover the topics necessary to master these techniques.

MR Imaging and Spectroscopy of the Developing Brain.- Congenital Malformation of the Brain.- Inherited Neurological Diseases and Disorders of Myelin.- Acquired Toxic and Metabolic Brain Disorders.- Tumors: Paratentorial Neoplasms.- Tumors: Supratentorial Neoplasms.- Brain Damage.- Miscellaneous.- Vascular Abnormalities.- Temporal Bone.- Spine.- Fetal Imaging.

This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.

Central nervous system (CNS) infections continue to pose a serious problem in health care even with improved knowledge and treatment. Despite the introduction of newer antimicrobial agents and diagnostic techniques, the morbidity and mortality associated with CNS infections remain high. The morbidity associated with CNS infections may be even more important than the death rate especially in developing countries as neurological sequelae may deprive the survivors of intellect and physical ability, demeaning the quality of life and burdening health resources and social services. MR imaging is an important integral part of the protocol for the management of CNS infections and MR spectroscopy is increasingly being utilized in its management. This work is an attempt to provide a comprehensive review of imaging and spectroscopy of the commonly encountered CNS infections in the clinical practice in developing and developed countries. The first chapter deals with basic physical principles of MR imaging and spectroscopy that will help beginners to understand the technical terms used in subsequent chapters. The remaining 10 chapters deal with clinical, pathological, MR imaging and spectroscopy features and their applications in CNS infections. This will help in giving a comprehensive understanding to readers with a background in clinical, radiological, basic MRI, and neurological sciences. The T2 hypointense lesions are a real diagnostic dilemma especially in developing countries for which an algorithm has been suggested in the concluding chapter.