Nanotechnology In Modern Medical Imaging And Interventions

The rapid progress of nanoscience and the application of nanotechnology in medicine are changing the foundations of disease prevention, diagnosis and treatment. At the core of nanotechnology for modern biomedical imaging and interventions, nano/microparticles offer 3-in-1 primary functions as imaging agents, target-specific probes, and target-specific therapeutic carriers. Nanoparticle-based imaging and interventions have already exhibited exciting potential in probing the bases or roots of diseases, such as to identify their altered molecular profiles and/or cellular characteristics prior to the appearance of visual anatomic alterations. As nanoparticle-based imaging and interventions continue to be refined and are increasingly applied to clinical practice, they will certainly have significant impact on global health care in the near future. Scientists from various disciplines around the world have already done outstanding work in developing various nanotechnology-based imaging modalities, such as molecular and cellular imaging with X-ray-based computerised tomography (CT), ultrasound, magnetic resonance (MR), optics, and nuclear medicine.However, clinical applications of these particle-based imaging techniques are still very limited. This can be attributed to a gap existing between basic science and clinical practice, where scientists have no direct access to patient care; meanwhile clinicians are extremely busy with their daily clinical practices and lack the time or means to learn such new technological evolutions. In order to bring the two parties together, a bridge needs to be built between basic science and clinical practice, as termed translational medicine by the US National Institute of Health (NIH). The aim of writing this book is to facilitate such translation of nanotechnology-based imaging modalities from laboratory benches to clinical practices. The authors come from several continents around the world, and are experts working in the fields of nanotechnology, material science, biomedical engineering, medicine, pathology, medical imaging, and interventional radiology. We hope this book will provoke common interest, brainstorming and co-operation among professionals in both technology and medicine, and will bring nanomedicine one step closer to improving patient care.

The rapid progress of nanoscience and the application of nanotechnology in medicine are changing the foundations of disease prevention, diagnosis and treatment. At the core of nanotechnology for modern biomedical imaging and interventions, nano/microparticles offer "3-in-1" primary functions as imaging agents, target-specific probes, and target-specific therapeutic carriers. Nanoparticle-based imaging and interventions have already exhibited exciting potential in probing the bases or "roots" of diseases, such as to identify their altered molecular profiles and/or cellular characteristics prior to the appearance of visual anatomic alterations. As nanoparticle-based imaging and interventions continue to be refined and are increasingly applied to clinical practice, they will certainly have significant impact on global health care in the near future. Scientists from various disciplines around the world have already done outstanding work in developing various nanotechnology-based imaging modalities, such as molecular and cellular imaging with X-ray-based computerized tomography (CT), ultrasound, magnetic resonance (MR), optics, and nuclear medicine. However, clinical applications of these particle-based imaging techniques are still very limited. This can be attributed to a gap existing between basic science and clinical practice, where scientists have no direct access to patient care; meanwhile clinicians are extremely busy with their daily clinical practices and lack the time or means to learn such new technological evolutions. In order to bring the two parties together, a bridge needs to be built between basic science and clinical practice, as termed "translational medicine" by the US National Institute of Health (NIH). The aim of writing this book is to facilitate such translation of nanotechnology-based imaging modalities from laboratory benches to clinical practices. The authors come from several continents around the world, and are experts working in the fields of nanotechnology, material science, biomedical engineering, medicine, pathology, medical imaging, and interventional radiology. We hope this book will provoke common interest, brainstorming and cooperation among professionals in both technology and medicine, and will bring nanomedicine one step closer to improving patient care.

Nanotechnology for Biomedical Imaging and Diagnostics: FromNanoparticle Design to Clinical Applications reflects upon theincreasing role of nanomaterials in biological and medical imaging,presenting a thorough description of current research as wellas future directions. With contributions from experts innanotechnology and imaging from academia, industry, andhealthcare, this book provides a comprehensive coverage of thefield, ranging from the architectural design of nanomaterials totheir broad imaging applications in medicine. Grouped into three sections, the book: Elucidates all major aspects of nanotechnology andbioimaging Provides comprehensive coverage of the field, ranging from thearchitectural design of nanomaterials to their broad imagingapplications in medicine Written by well-recognized experts in academia, industry, andhealthcare, will be an excellence source of reference With a multidisciplinary approach and a balance of research anddiagnostic topics, this book will appeal to students, scientiests,and healthcare professionals alike

The current generation of imaging nanoparticles is diverse and dependent on its myriad of applications. This book provides an overview of how these imaging particles can be designed to fulfill specific requirements for applications across different imaging modalities. It presents, for the first time, a comprehensive interdisciplinary overview of the impact nanoparticles have on biomedical imaging and is a common central resource for researchers and teachers.

Magnetic Nanoparticles in Human Health and Medicine Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine. Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, ­biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer ­therapeutics—featuring discussion of current problems, ­proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume: Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome. Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine. This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field. Contents:Combining Imaging and Drug Delivery for the Treatment of Severe Diseases (Simona Mura and Patrick Couvreur)Increased Sensitivity for Medical Imaging Using Non-Ionizing Nanomedicine as Contrast Agents (Cyrille Richard, Bich-Thuy Doan and Nathalie Mignet)MRI T2 Weighted Theranostic Nanodevices and Chemotherapy (Sophie Laurent, Luce Vander Elst, Dimitri Stanicki and Robert N Muller)MRI T1 Weighted Theranostic Nanodevices (Lucie Sancey, François Lux, Géraldine Le Duc, Sabin Carme and Olivier Tillement)Optical Imaging and Chemotherapy (Guillaume Bort, Simona Mura and Patrick Couvreur)Plasmonic Nanoparticles-Coated Microbubbles for Theranostic Applications (Mark A Borden, Jacob D Dove and Todd W Murray)Contribution of Nuclear Medicine to Cancer Nanotheranostics (Thomas Lars Andresen, Anncatrine L Petersen, Anders E Hansen and Jonas R Henriksen)Nanotheranostics in Gene Therapy (Madhura Deshpande, Shravan Kumar Sriraman and Vladimir Torchilin)Nanotheranostics in Cardiovascular Diseases (Maya Juenet, Mariana Varna, Cédric Chauvierre and Didier Letourneur)Stimuli-Responsive Nanotheranostics (Basit Yameen, Jun Wu, Critian Vilos, Andrew Whyte David Werstler, Lori Pollit and Omid C Farokhzad)Advancing the Practical Clinical Utility in Personalized Medicine: Capabilities and Lessons Learned for Pharmacology and Pharmaceutics (Ioannis S Vizirianakis, Christina Karavasili, Elsa P Amanatiadou and Dimitrios G Fatouros) Readership: Advanced undergraduates, graduates, as well as experimental researchers in academia or the industry with an interest in this emerging concept in the nanomedicine world. Key Features:This book presents an integrated and transdisciplinary description of an emerging concept in the world of nanomedicine: nanotheranosticsThis work is one of the few dedicated to nanotheranostics and its applicationsWritten by well-recognized experts in academia, this book would offer to the reader a clear overview of the progresses in the field of nanotheranostics and their fundamental contribution to the field of personalized medicineReading this book would open the way to further improvements and to the possible clinical translation of the nanotheranostics concept in the not-too-distant futureKeywords:Bioengineering;Nanomedicine & Nanobiology;Biomedical Engineering;Medical Imaging;Therapy

Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A valuable resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A detailed guide to recent scientific progress, along with the latest application methods Presents innovative opportunities and ideas for developing or improving technologies in nanomedicine and medical imaging

This book intends to provide an up-to-date information in the field of nanobiomedicine. The focus of the book is on the basic concepts and recent developments in the field of nanotechnology. This book covers a broad spectrum of nanomaterials processing, structural characteristics, and related properties and will include bio-probes, medical imaging, drug delivery, and tumor diagnosis. Critical issues are addressed in a straightforward manner so those with no technical background and university students can benefit from the information. Furthermore, many novel concepts in nanomaterials are explained in light of current theories. An important aspect of the book lies on its wide coverage in practical biomedical applications. Not only are the cutting-edge technologies in modern medicine introduced, but also unique materials applications in many clinical areas. Contents:Up-Conversion Nanoparticles for Early Cancer Diagnosis (Liang Cheng, Bingbo Zhang and Zhuang Liu)Redox-Sensitive Polymeric Nanoparticles for Intracellular Drug Delivery (Huiyun Wen, Yongyong Li and Xin Zhao)Design of Biocompatible PEIs as Artificial Gene Delivery Vectors (Ting Shi, Chao Lin and Peng Zhao)Magnetic Fe3O4 Nanoparticles for Cancer Photothermal Therapy (Maoquan Chu)Nanomaterial-Based Sensors for Environmental Monitoring (Jinhu Yang)Janus Nanostructures and Their Bio-Medical Applications (Yilong Wang and Feng Wang)Nanomaterial-Involved Optical Imaging/Spectroscopy Methods for Single-Molecule Detections in Biomedicine (Yao Qin)Surface Functionalized Carbon Nanotubes for Biomedical Applications (Bingdi Chen)Intracellular siRNA Delivery by Multifunctional Nanoparticles (Kun Lu, Lei Wang, Xiaohui Tan, Yao Chen, Changhui Wang and Lifeng Qi)Chemical and Biological Sensors Based on Nanowire Transistors (Xiaohan Wu and Jia Huang) Readership: Undergraduate or graduate students, and researchers in nanomaterials, biochemistry, biomedical engineering. Key Features:It is closely clinically oriented in medical diagnosis and treatmentIt is comprehensive in both nanomaterials and biomedical applicationsIt includes many novel concepts in nanotechnology and up to dateKeywords:Nanomedicine;Nanobiomedicine;Nanobiotechnology;Nanomaterials;Bio-Probes;Medical Imaging;Drug delivery;Tumor Diagnosis