Natural Products For Cancer Chemoprevention

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research.

This book is a printed edition of the Special Issue "Natural Products for Cancer Prevention and Therapy" that was published in Nutrients

The book presents a comprehensive and up-to-date overview of phytochemicals as efficient cancer therapeutics. Over the last few decades there has been a paradigm shift from conventional cancer therapeutic approaches to alternative and complementary medicinal approaches especially using phytoconstituents from natural products. As such, the book provides an in-depth understanding of phytochemicals targeting diverse signaling pathways involved in cancer along with the evaluation of the cancer modulatory effects of phytochemicals. It also highlights the potential modulatory effect of single nucleotide polymorphisms (SNPs) on the cancer-associated cellular pathways and their interactions with the phytochemicals. Further, it analyzes the drug delivery methods, bioavailability of active components of botanicals, and toxicity of phytochemicals. Lastly, the book elucidates the 3D cell culture and animal models systems to analyze the beneficial effects of phytochemicals in cancer.

This book covers various aspects of cancer chemoprevention, including an overview of chemoprevention in the process of tumorigenesis; the roles of various phytochemicals, functional foods, and dietary interventions in disease prevention; and techniques such as cancer stem cell targeting, nano-formulations, and so forth. The nutrigenomic and epigenetic effects of natural products at the molecular and genetic levels are also covered alongside their potential for additive and synergistic effect, as well as overcoming drug resistance. The key selling features of the book are as follows: Discusses holistic and comprehensive areas of chemoprevention Includes diverse techniques, such as cancer stem cell targeting, nano-formulations, and nanotechnology-based drug delivery systems Introduces various mechanisms involved in prevention of the diseases, including targeting cancer stem cells Reviews various aspects which can reduce the toxicity and cost of treatment of diseases by alternative medicine Explores various sources, mechanisms, and ways to develop cancer chemopreventive agents with minimal toxicity compared to traditional cancer therapy drugs This book is focused on researchers and graduate students in drug delivery and formulation, nanobiotechnology, cancer chemoprevention, prevention, and therapeutics.

During the past decade, a significant amount of research has been conducted on phytopharmaceuticals. Today, a growing body of evidence demonstrates the efficacy of a wide variety of natural products and affirms their potential in the treatment of cancer. Phytopharmaceuticals in Cancer Chemoprevention focuses on the role of natural supplemen

This book discusses the efficacy of various naturally occurring chemopreventive agents in preventing or delaying cancer. It focuses on the holistic chemopreventive concept, demonstrating the relevant response is the combined effect of a series of compounds that alone have been shown to have some effect in different experimental models. Written by leading experts in the field, the contributions provide details of research on various chemopreventive agents. Offering insights into the unique molecular targets and mechanisms, safety issues, molecular efficacy, and occurrence in nature of these compounds, the book is a valuable resource for all scientists working in biomedicine, and specifically in cancer research. .

Natural Substances for Cancer Prevention explores in detail how numerous investigations in chemical biology and molecular biology have established strong scientific evidence demonstrating how the properties of naturally occurring bioactive chemicals hamper all stages of cancers (from initiation to metastasis). Accordingly, important goals for cancer prevention are the modification of our dietary habits and an increase in the intake of more anticancer-related natural substances. More significantly, the bioactive chemicals presented in the functional foods should be readily available, inexpensive, non-toxic, and nutritional.

Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries, by Gary D. Stoner and Li-Shu Wang Cancer Prevention by Different Forms of Tocopherols, by Chung S. Yang and Nanjoo Suh Cancer Chemopreventive and Therapeutic Potential of Guggulsterone, by Inas Almazari and Young-Joon Surh Inhibition of UVB-Induced Nonmelanoma Skin Cancer: A Path from Tea to Caffeine to Exercise to Decreased Tissue Fat, by Allan H. Conney, You-Rong Lou, Paul Nghiem, Jamie J. Bernard, George C. Wagner and Yao-Ping Lu Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges, by Clarissa Gerhauser A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics, by Zheng-Yuan Su, Limin Shu, Tin Oo Khor, Jong Hun Lee, Francisco Fuentes and Ah-Ng Tony Kong Keap1-Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane, by Thomas W. Kensler, Patricia A. Egner, Abena S. Agyeman, Kala Visvanathan, John D. Groopman, Jian-Guo Chen, Tao-Yang Chen, Jed W. Fahey and Paul Talalay Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms, by Albena T. Dinkova-Kostova Human Cancer Chemoprevention: Hurdles and Challenges, by Vaqar Mustafa Adhami and Hasan Mukhtar Personalizing Lung Cancer Prevention Through a Reverse Migration Strategy, by Kathryn A. Gold, Edward S. Kim, Ignacio I. Wistuba and Waun K. Hong Natural-Agent Mechanisms and Early-Phase Clinical Development, by Janet L. Wang, Kathryn A. Gold and Scott M. Lippman