Neurobiology

Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

It is often difficult to blend the knowledge from scientific research with the experience of clinical practice. This book does exactly that. By incorporating recent advances in biological sciences with the concept of aetiology and treatment of eating disorders, the editors have successfully produced an authoritative, state-of-the-art text. The internationally renowned authors suggest ways of integrating the latest findings within a treatment setting. Topics covered include: ? Phenomenology ? Measurement of Psychopathology ? Stress, Neurobiology and Eating ? Eating Behaviour and Weight Control ? Emotional States and Bulimic Psychopathology ? Neuroimaging ? Treatment of Anorexia Nervosa ? Treatment of Binge Eating Disorder ? Pharmacotherapy ? Nutritional Management ? Medical Complications. This book will be of value to all psychiatrists, psychologists, psychopharmacologists and clinical neuroscientists. From pre-publication reviews: "This book provides a masterly synthesis of the basic and the clinical, in a form that should prove useful to both practicing clinicians and researchers in the field. I know of no other book of comparable scope that has attempted so successfully this integration." James E. Mitchell Professor and Chairman, Department of Neurosciences, UND, Fargo, USA "Neurobiology in the Treatment of Eating Disorders is a major achievement and I predict that it will become an instant classic." Ruth Striegel-Moore Professor and Chair, Department of Psychology, Wesleyan University, CT, USA "A significant addition to the literature on eating disorders. This book is notable for its depth and breadth, the emphasis on neurobiology being particularly distinctive and welcome. It deserves to be widely read." Christopher Fairburn Professor, Department of Psychiatry, University of Oxford UK "I found this book absolutely outstanding and was very pleased to read it. This invaluable and authoritative overview represents an outstanding reference for the study of the three major disorders of eating behaviour. This book represents an extraordinary background for future developments of neurobiological and genetic investigations, clinical applications, epidemiological studies; therapeutic approaches and prevention programs." Francesca Brambilla Professor, Department of Neuropsychiatric Sciences, H. S. Raffaele, Milan, Italy

Every clinician today needs a basic understanding of what causes violent behavior. The second edition of Neurobiology of Violence synthesizes current research on the origins of violence and reveals its implications for managing aggressive patients and minimizing risk. Author Jan Volavka, currently Chief of Clinical Research at the Nathan S. Kline Institute, spent time in a Nazi prison as a child and has devoted much of his career to studying violence in humans. In Neurobiology of Violence, Second Edition, he brought together research and clinical data from many diverse disciplines in a single-authored volume with a unified voice that is clearly written and interesting to read. Neurobiology of Violence, Second Edition, will give you a firm grounding in a complex subject that will help you diagnose, manage, and predict violent behavior. In the first part of the book you'll examine the basic science of the origins of violence in humans, such as Factors in animal aggression that have parallels in human aggression, including the relationship between serotonin and aggression The genetic and environmental factors that interplay from conception to adulthood to result in violence. In the latter part, you'll develop new insights and strategies for working with violent patients in discussions of the latest clinical science, including Major mental disorders and violent behaviors, including behaviors expressed in the community and those in psychiatric hospitals Alcohol and various drugs and the tendencies of each type of abuse to predispose people to violence Current psychopharmacological approaches to managing violent behavior in patients. With more than 1000 updated references, the second edition of Neurobiology of Violence is a seminal resource for clinicians. It is an important tool for psychiatrists, neurologists, psychologists, and all other clinicians who struggle to understand and treat violent patients.

In the past two decades, there have been astonishing advances in our understanding of the neurobiological basis and nature of drug addiction. We now know the initial molecular sites of action, at identified receptors, of virtually all of the major drugs of abuse including cocaine, heroin, and amphetamine, as well as legal drugs such as nicotine and alcohol. We also understand the main components of a 'reward system' and its connections to major brain regions involved in motivation and emotion, such as the amygdala, hippocampus, and prefrontal cortex. The Neurobiology of Addiction describes the latest advances in our understanding of addiction. It brings together world class researchers to debate the nature and extent of addiction, as well as its causes, consequences, and treatment. The focus of the book is on the brain processes underlying addiction, in terms of neural systems, neurochemical basis, and molecular changes. Several types of addiction are discussed ranging from illicit drugs - cocaine, amphetamine, and heroin to legal drugs - alcohol and nicotine. In addition, it explores increasingly common behavioural addictions such as gambling and obesity. Included are chapters on vulnerability to addiction, genetic factors, opponent motivational processes, animal models, relapse, cognitive deficits associated with drug abuse, new pharmacological treatments, and current controversies concerning different neuropsychological theories of addiction. Throughout, it reports on cutting edge research using brain imaging, and state of the art molecular methodology. The book will make fascinating reading for students and teachers in the field of neuroscience, pharmacology and psychology, as well as experts in the field.

In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings -- and their impact on psychiatry. You'll learn about Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.

Facilitating change in couple therapy by understanding how the brain works to maintain—and break—old habits. Human brains and behavior are shaped by genetic predispositions and early experience. But we are not doomed by our genes or our past. Neuroscientific discoveries of the last decade have provided an optimistic and revolutionary view of adult brain function: People can change. This revelation about neuroplasticity offers hope to therapists and to couples seeking to improve their relationship. Loving With the Brain in Mind explores ways to help couples become proactive in revitalizing their relationship. It offers an in-depth understanding of the heartbreaking dynamics in unhappy couples and the healthy dynamics of couples who are flourishing. Sharing her extensive clinical experience and an integrative perspective informed by neuroscience and relationship science, Mona Fishbane gives us insight into the neurobiology underlying couples’ dances of reactivity. Readers will learn how partners become reactive and emotionally dysregulated with each other, and what is going on in their brains when they do. Clear and compelling discussions are included of the neurobiology of empathy and how empathy and selfregulation can be learned. Understanding neurobiology, explains Fishbane, can transform your clinical practice with couples and help you hone effective therapeutic interventions. This book aims to empower therapists— and the couples they treat—as they work to change interpersonal dynamics that drive them apart. Understanding how the brain works can inform the therapist’s theory of relationships, development, and change. And therapists can offer clients “neuroeducation” about their own reactivity and relationship distress and their potential for personal and relational growth. A gifted clinician and a particularly talented neuroscience writer, Dr. Fishbane presents complex material in an understandable and engaging manner. By anchoring her work in clinical cases, she never loses sight of the people behind the science.

Neurobiology of Sleep and Memory is the textual result of a symposium regarding the basic neurological processes in the storage of different kinds of memories (short-term and long-term). This book gives much focus on the relationship of sleep and memory and how they preserve personality and all its characteristics. The study of the interrelation of the two bodily processes also aims to help clarify neurological bases of disorders of sleep and memory and other forms of mental illness. This text consists of 23 chapters that encompass a wide span of topics regarding sleep and memory. Some of these topics include blood-brain barrier; protein synthesis in RNA and central nervous system; neuronal activity patterns during REM sleep; post-trial reticular stimulation; and sleep-related hormones. This book also discusses the phylogenetic correlations of sleep and memory not just in mammals but also in reptiles, amphibians, fishes, and birds. This reference material is a valuable source of information to both students and professionals studying biology, psychology, pharmacology, and neuroscience.

This book summarises the recent development in acupuncture research and in particular, the neurobiology of acupuncture. It provides a focus but a diverse range of subjects covering many body systems. The first a few chapters discuss the basic principles of acupuncture, then its modulatory effects on nervous system such as induction of neurotrophin and neurogenesis in the brain. Late chapters explore the clinical effects and potential mechanisms of acupuncture on different conditions ranging from neurological diseases such as Parkinson’s, Alzheimer’s, and stroke, to psychiatric illnesses, insomnia, hypertension, gastrointestinal diseases and drug addiction. We believe this will promote the understanding acupuncture treatment and enhance acupuncture research in the future. This volume of International Review of Neurobiology brings together cutting-edge research on the neurobiology of acupuncture It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery