Neuropadiatrie

Niedermeyer's Electroencephalography: Basic Principles, Clinical Applications, and Related Fields, Seventh Edition keeps the clinical neurophysiologist on the forefront of medical advancements. This authoritative text covers basic neurophysiology, neuroanatomy, and neuroimaging to provide a better understanding of clinical neurophysiological findings. This edition further delves into current state-of-the-art recording EEG activity both in the normal clinical environment and unique situations such as the intensive care unit, operating rooms, and epilepsy monitoring suites. As computer technology evolves, so does the integration of analytical methods that significantly affect the reader's interpretations of waveforms and trends that are occurring on long-term monitoring sessions. Compiled and edited by Donald L. Schomer and Fernando H. Lopes da Silva, along with a global team of experts, they collectively bring insight to crucial sections including basic principles of EEG and MEG, normal EEG, EEG in a clinical setting, clinical EEG in seizures and epilepsy, complementary and special techniques, event-related EEG phenomena, and shed light on the future of EEG and clinical neurophysiology. Akin to an encyclopedia of everything EEG, this comprehensive work is perfect for neurophysiology fellows, as well as neurology, neurosurgery, and general medical residents, and for the interns and medical students, and is a one-stop-shop for anyone training in EEG or preparing for neurophysiology or epilepsy board exams.

A keyword listing of serial titles currently received by the National Library of Medicine.

Preface This book describes problems and results of research in the gap between two fields: Human genetics, and clinical neurophysiology. Whenever I talked about my research on the genetics of the EEG, the answer of human geneticists was: "Very interesting, but I do not understand anything about the EEG. " On the other hand, EEG specialists usually remark: "Very interesting, but I do not understand anything about human genetics. " This is why I wrote this book. It tries to summarize results my own and from some others - and to point to problems. In the from researc- light of the recent progress especially in human molecular genetics, this field of research promises deep insights into biological mechanisms of brain function, as well as genetic variation involved in mental performance, and personality of humans. However, the logistic problems of such studies are not easy to overcome: It is necessary to study carefully ascertained population samples either of "normal" persons, or of persons selected for phenotypic characteristics that are not easy to diagnose. Moreover, EEG diagnosis and classification must be very specific, and is not trivial at all. All these problems require careful preparations at various levels, long-lasting efforts, and patience. Of this I am sure, however: The results would justify the efforts. I am too old to plan such a program myself; moreover, as an emeritus professor, I do not have the means for such studies.

This volume provides updated information on epilepsy genes, on the clinical picture of genetic epilepsies discovered so far, and on conceptual advances in the complicated area of genotype-phenotype correlations. Recent studies on monogenic epilepsies present new insights into mechanisms whereby a mutation of a single gene, coding for an ion channel, can result in a complex epileptic phenotype. The analysis of genetically-determined epileptogenic dysplasia is advancing our understanding of the role of genes in controlling normal and pathological brain development. The pathogenic mechanisms by which gene mutations determine progressive myoclonus epilepsies offer critical opportunities to understand the role of genetic factors in neurodegenerative phenome-na associated with an even broader range of progressive epilepsy types. The specialists who have contributed to this book are outstanding international experts in their respective fields, ensuring first and foremost that the reviews are of relevance to clinicians dealing with epilepsy in their daily practice, as well as providing the highest quality scientific information for biomedical research.

This book provides neurologists, geneticists, pediatricians, and pharmacologists with basic knowledge for genetic counselling, while putting emphasis on the evidence of heterogeneity in this field. The volume contains separate sections on population rates, family studies on selected syndromes, and special methods and topics. Two particularly topical questions concern the prospective evaluation of morbidity risk for seizures in offspring of epileptic patients and the relationship of pharmacogenetics to epilepsy. The book aims to stimulate communication across traditional disciplinary lines and to further collaborative research.

In order to supplement Dr. Johnson's review we wish to make two points: I) not all grossly similar lesions should be considered t. o be due to the same etiology, even if experimentally documented, and 2) relatively few infections (syphilis, toxoplasmosis, cytomegalovirus, herpesvirus and rubella) and no immunologic disorders (except for kernicterus due to hyperbilirubinemia) are known to affect the developing human nervous system. Admittedly, since most human malformations are of unproven cause, these two points are not mutually exclusive. Rather, the challenge remains to show that any of the experimental models relates to any of the human diseases. In particular, the porencephaly-hydranencephaly spectrum could be due to ischemia in the watershed distribution of one or more branches of the internal carotid ar teries; and aqueductal stenosis could be due to secondary blockage by blood clots or debris related to hemorrhage or necrosis in the germinal matrix or periventricular white matter, lesions most likely due to hypoxia-acidosis in premature infant, who die most often of the concomitant respiratory distress syndrome. REFERENCES Altshuler. G. : Toxoplasmosis as a cause of hydranencephaly. Am. l. Dis. Child. 125: 251-252 (1973). Beer. A.E. and Billingham. R.E. : Immunobiology of mammalian reproduction. Adv. Immunol. 14: 1-84 (1971). Berenberg. W. and Nakervis. G. : Long-term follow-up of cytomegalic inclusion disease of in fancy. Pediatrics 46: 403-410 (1970). Boniuk. M. and Zimmerman. L.E. : Ocular pathology in the rubella syndrome. Arch. Ophthalmo!. 77: 455-473 (1967).

Readable, concise, and data-driven, Current Practice of Clinical Electroencephalography, 5th Edition, delivers a comprehensive overview of the dynamic field of EEG. Dr. Aatif M. Husain leads a team of internationally recognized authors who provide updates on established areas of clinical EEG, discuss newly evolving areas, and explain neurophysiological basis of pathology to encourage understanding rather than simply pattern recognition. Now in full color throughout, it’s a must-have resource for residents, neurologists, clinical neurophysiologists, epilepsy specialists, electroneurodiagnostic technologists and practicing electroencephalographers, as well as students, trainees, and researchers—anyone who desires to stay up to date and use EEG to its fullest potential.