New Trends In Synthetic Medicinal Chemistry Volume 7
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New Trends in Synthetic Medicinal Chemistry Volume 7
Author | : F. Gualtieri |
Publsiher | : Wiley-VCH |
Total Pages | : 382 |
Release | : 2000-03-22 |
Genre | : Medical |
ISBN | : UOM:39015050308777 |
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The long-awaited volume on synthetic chemistry in the series "Methods and Principles in Medicinal Chemistry" is now available. In the pharmaceutical industry, computational methods play a major role in the discovery and development of new drugs. Yet, the SYNTHESIS of these compounds still remains the most crucial topic in drug design. Written by an internationally renowned team of authors and editors from academia and industry, this volume describes all recent developments in organic synthetic methodology which are essential for pharmaceutical research. The most modern synthetic developments of pharmacologically interesting compounds (carbohydrates and nucleotides) as well as important synthetic methods such as combinatorial chemistry, solid-phase reactions, bioassisted organic synthesis and asymmetric synthesis are critically discussed. Special emphasis is given to a hands-on practical approach which enables researchers to apply the featured methods immediately to their specific problems. Also, the detailed presentation of the topic and the selection of references will be of help to any researcher working in the laboratory.
The Organic Chemistry of Drug Synthesis Volume 7
Author | : Daniel Lednicer |
Publsiher | : John Wiley & Sons |
Total Pages | : 288 |
Release | : 2007-12-14 |
Genre | : Science |
ISBN | : 9780470180662 |
Download The Organic Chemistry of Drug Synthesis Volume 7 Book in PDF, Epub and Kindle
The classic reference on the synthesis of medicinal agents -- now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6. Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.
New Developments in Medicinal Chemistry
Author | : Carlton Anthony Taft,Carlos Henrique Tomich de Paula Da Silva |
Publsiher | : Bentham Science Publishers |
Total Pages | : 162 |
Release | : 2010-12-30 |
Genre | : Medical |
ISBN | : 9781608051274 |
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"This book is recommended for readers who are interested in or work with current theoretical and experimental research in medicinal chemistry, with an emphasis on computer aided-drug design and organic synthesis for therapeutic purposes. This book encompas"
Synthetic Methods in Drug Discovery
Author | : David C. Blakemore,Paul M. Doyle,Yvette M. Fobian |
Publsiher | : Royal Society of Chemistry |
Total Pages | : 536 |
Release | : 2016 |
Genre | : Drug development |
ISBN | : 9781782627869 |
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The number of available synthetic methods can be overwhelming. In order to create novel motifs and templates which confer new and potentially valuable drug-like properties, it is important to know which synthetic methodologies will give the best results. Similarly, which methodologies are used to progress potential drug candidates from leads through the development process? What are the current industrial research problems and how can they be resolved in an industrial setting? This book highlights key methods that have real impact in drug discovery and facilitate delivery of drug molecules. Synthetic Methods in Drug Discovery Volume 1 focuses on the hugely important area of transition metal mediated methods used in industry. Current methods of importance such as the Suzuki-Miyaura coupling, Buchwald-Hartwig couplings and CH activation are discussed. In addition, exciting emerging areas such as decarboxylative coupling, and the uses of iron and nickel in coupling reactions are also covered. This book provides both academic and industrial perspectives on some key reactions giving the reader an excellent overview of the techniques used in modern synthesis. Reaction types are conveniently framed in the context of their value to industry and the challenges and limitations of methodologies are discussed with relevant illustrative examples. Edited and authored by leading scientists from both academia and industry, this book will be a valuable reference for all chemists involved in drug discovery as well as postgraduate students in medicinal chemistry.
Small Molecule Medicinal Chemistry
Author | : Werngard Czechtizky,Peter Hamley |
Publsiher | : John Wiley & Sons |
Total Pages | : 546 |
Release | : 2015-11-02 |
Genre | : Science |
ISBN | : 9781118771600 |
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Stressing strategic and technological solutions to medicinal chemistry challenges, this book presents methods and practices for optimizing the chemical aspects of drug discovery. Chapters discuss benefits, challenges, case studies, and industry perspectives for improving drug discovery programs with respect to quality and costs. • Focuses on small molecules and their critical role in medicinal chemistry, reviewing chemical and economic advantages, challenges, and trends in the field from industry perspectives • Discusses novel approaches and key topics, like screening collection enhancement, risk sharing, HTS triage, new lead finding approaches, diversity-oriented synthesis, peptidomimetics, natural products, and high throughput medicinal chemistry approaches • Explains how to reduce design-make-test cycle times by integrating medicinal chemistry, physical chemistry, and ADME profiling techniques • Includes descriptive case studies, examples, and applications to illustrate new technologies and provide step-by-step explanations to enable them in a laboratory setting
New Tide of Natural Product Chemistry
Author | : Hayato Ishikawa,Hiromitsu Takayama |
Publsiher | : Springer |
Total Pages | : 0 |
Release | : 2023-06-30 |
Genre | : Science |
ISBN | : 9819917131 |
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This book highlights recent research and advances in natural product chemistry written by promising young researchers in this field who have played a central role for recent innovative advancements. The book consists of seventeen chapters covering novel bioactive natural products, uncovering life phenomena with natural products, biosynthesis of natural products, total synthesis of complex natural products by innovative strategies, and drug discovery using natural products. Each chapter begins with a brief and easy-to-understand introduction, then presents the cutting-edge research in each individual specialty. This book is not only a practical and essential reference resource for natural product chemists, medicinal chemists, synthetic organic chemists, biochemists, pharmacologists, as well as the pharmaceutical and biotechnological industries, but is also a useful guide to understanding new and emerging trends in this field.
The Organic Chemistry of Drug Synthesis
![The Organic Chemistry of Drug Synthesis](https://youbookinc.com/wp-content/uploads/2024/06/cover.jpg)
Author | : Daniel Lednicer,Lester A. Mitscher |
Publsiher | : Wiley-Interscience |
Total Pages | : 1856 |
Release | : 1996-05-09 |
Genre | : Science |
ISBN | : 0471169900 |
Download The Organic Chemistry of Drug Synthesis Book in PDF, Epub and Kindle
The classic reference on the synthesis of medicinal agents --now completely updated The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6.Many of these compounds represent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered. As in the previous volumes, materials are organized by chemical class and syntheses originate with available starting materials. Organized to make the information accessible, this resource covers disease state, rationale for method of drug therapy, and the biological activities of each compound and preparation. The Organic Chemistry of Drug Synthesis, Volume 7 is a hands-on reference for medicinal and organic chemists, and a great resource for graduate and advanced undergraduate students in organic and medicinal chemistry.
Drug Design
Author | : E. J. Ariëns |
Publsiher | : Elsevier |
Total Pages | : 312 |
Release | : 2013-10-22 |
Genre | : Medical |
ISBN | : 9781483216096 |
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Drug Design, Volume VII covers the design of agents such as blood substitutes, pesticides derived from insect pheromones, and herbicides related to the auxin-type plant hormones. The book discusses the design of artificial blood substitutes and auxin-type herbicides; the use of insect pheromones as a basis for the development of more effective selective pest control agents; and the development and application of new steric substituent parameters in drug design. The text also describes the use of computer technology in drug design. Pharmacologists, chemists, biochemists, and people involved in drug design and manufacture will find the book invaluable.