Ntp Technical Report On The Toxicology And Carcinogenesis Studies Of 1 Chloro 2 Propanol Technical Grade Cas No 127 00 4 In F344 N Rats And B6c3f1 Mice Drinking Water Studies

During the last two decades, molecular epidemiology has become an important discipline in cancer research. It has evolved towards the development, validation and application of markers of susceptibility and, more recently, markers of mechanisms of cancer development. This volume on mechanisms of carcinogenesis covers from an interdisciplinary perspective, the contribution of molecular epidemiology to the understanding of mechanisms of carcinogenesis, and represents a further contribution to the development of molecular epidemiology as a major cancer research domain.

Bromochloroacetic acid is a water disinfection by-product. Bromochloroacetic acid was nominated for toxicity and carcinogenicity studies in rats and mice because of widespread human exposure and because a related dihaloacetate, dichloroacetate, was found to be carcinogenic to the liver of rats and mice. Drinking water was selected as the route of exposure to mimic human exposure to this chemical. Male and female F344/N rats and B6C3F1 mice were exposed to bromochloroacetic acid (greater than 95% pure) in drinking water for 2 weeks, 3 months, or 2 years. Genetic toxicology studies were conducted in ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ and peripheral blood erythrocytes of exposed mice. Illustrations.

Methylene Blue Trihydrate (MBT) has a variety of biomedical and biologically therapeutic applications. MBT was nominated by the Nat. Cancer Inst. for carcinogenecity testing based on the numerous uses of this compound and the lack of long-term toxicity data, including epidemiological studies of MBT, as well as the inadequate animal data on this compound. Male and female F344/N rats and B6C3F1 mice were administered MBT in 0.5% aqueous methylcellulose by gavage for 1 month, 3 months, or 2 years. Genetic toxicology studies were conducted using ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ cultured Chinese hamster ovary cells, mouse bone marrow cells, and mouse peripheral blood erythrocytes. Illustrations.