Nucleus

From Nucleons to Nucleus deals with single-particle and collective features of spherical nuclei. Each nuclear model is introduced and derived in detail. The formalism is then applied to light and medium-heavy nuclei in worked-out examples, and finally the acquired skills are strengthened by a wide selection of exercises, many relating the models to experimental data. Nuclear properties are discussed using particles, holes and quasi-particles. From Nucleons to Nucleus is based on lectures on nuclear physics given by the author, and serves well as a textbook for advanced students. Researchers too will appreciate it as a well-balanced reference to theoretical nuclear physics.

The nucleus is the most prominent structure in eukaryotic cells. It houses the cell's DNA and is the hub for DNA replication, transcription, and RNA processing. Despite its prominence and importance, our understanding of how the nucleus and its DNA are organized in space and time--and the implications of that organization for proper function--has lagged behind that of other cellular structures. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers recent advances in our understanding of nuclear organization and function. The contributors discuss the 3D organization of chromatin, the various nuclear bodies and compartments that have been identified, and the roles of RNA and actin in shaping nuclear organization, as well as how these structures interact with each other and with peripheral features (e.g., the nuclear pore complex and inner nuclear membrane proteins) to carry out the work of the nucleus. Insights into DNA replication timing and RNA processing dynamics based on new technologies aimed at examining chromatin and other intranuclear structures at high resolution are also included. Multiple chapters are devoted to physiological and disease processes involving disruption of nuclear structure and function (e.g., viral infection). This volume is therefore essential reading for all cell and molecular biologists, as well as pathologists interested in the role of nuclear architecture in disease.

A graduate-level one-volume textbook and reference work on the structure and physics of atomic nuclei. Throughout this book the underlying emphasis is on how a nucleus is constituted through the interaction between the nucleons. The book is structured into three parts: the first part contains a detailed treatment of the two-nucleon force and of basic model-independent nuclear properties the second part discusses the experimental results of nuclear models and their bases in fundamental theory the third part deals in some detail with alpha-decay and fission.

The discovery of the nucleus transformed the past century and will revolutionize this one. Nuclear physics is one of the most exciting—and useful—branches of science. In medicine, it helps save lives through innovative medical technologies, such as the MRI, and in nuclear astrophysics, state-of-the-art theoretical and computer models account for how stars shine and describe how the chemical elements in the universe were formed. Now in its second edition, Nucleus tells the story of the nucleus from the early experimental work of the quiet New Zealander Lord Rutherford to the huge atom-smashing machines of today and beyond. Thoroughly revised and updated, the book includes the most current information on the radio dating of Earth and other planets in the Solar System, heavy-ion therapies, quark-gluon plasma and its relevance to black holes, and clarification of ab initio calculations of atomic nuclei. Lavishly illustrated and with lively prose and captivating details, this book unravels the scientific mysteries that surround the subject of the nucleus. Anyone with even a passing interest in science will delight in this guide to the nuclear age.

All living things on Earth are composed of cells. A cell is the simplest unit of a self-contained living organism, and the vast majority of life on Earth consists of single-celled microbes, mostly bacteria. These consist of a simple 'prokaryotic' cell, with no nucleus. The bodies of more complex plants and animals consist of billions of 'eukaryotic' cells, of varying kinds, adapted to fill different roles - red blood cells, muscle cells, branched neurons. Each cell is an astonishingly complex chemical factory, the activities of which we have only begun to unravel in the past fifty years or so through modern techniques of microscopy, biochemistry, and molecular biology. In this Very Short Introduction, Terence Allen and Graham Cowling describe the nature of cells - their basic structure, their varying forms, their division, their differentiation from initially highly flexible stem cells, their signalling, and programmed death. Cells are the basic constituent of life, and understanding cells and how they work is central to all biology and medicine. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

This volume presents detailed, recently-developed protocols ranging from isolation of nuclei to purification of chromatin regions containing single genes, with a particular focus on some less well-explored aspects of the nucleus. The methods described include new strategies for isolation of nuclei, for purification of cell type-specific nuclei from a mixture, and for rapid isolation and fractionation of nucleoli. For gene delivery into and expression in nuclei, a novel gentle approach using gold nanowires is presented. As the concentration and localization of water and ions are crucial for macromolecular interactions in the nucleus, a new approach to measure these parameters by correlative optical and cryo-electron microscopy is described. The Nucleus, Second Edition presents methods and software for high-throughput quantitative analysis of 3D fluorescence microscopy images, for quantification of the formation of amyloid fibrils in the nucleus, and for quantitative analysis of chromosome territory localization. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, The Nucleus, Second Edition seeks to serve both professionals and novices with its well-honed methods for the study of the nucleus.

By way of its clear and logical structure, as well as abundant highresolution illustrations, this is a systematic survey of the players and pathways that control genome function in the mammalian cell nucleus. As such, this handbook and reference ties together recently gained knowledge from a variety of scientific disciplines and approaches, dissecting all major genomic events: transcription, replication, repair, recombination and chromosome segregation. A special emphasis is put on transcriptional control, including genome-wide interactions and non-coding RNAs, chromatin structure, epigenetics and nuclear organization. With its focus on fundamental mechanisms and the associated biomolecules, this will remain essential reading for years to come.

In 1974 India joined the elite roster of nuclear world powers when it exploded its first nuclear bomb. But the technological progress that facilitated that feat was set in motion many decades before, as India sought both independence from the British and respect from the larger world. Over the course of the twentieth century, India metamorphosed from a marginal place to a serious hub of technological and scientific innovation. It is this tale of transformation that Robert S. Anderson recounts in Nucleus and Nation. Tracing the long institutional and individual preparations for India’s first nuclear test and its consequences, Anderson begins with the careers of India’s renowned scientists—Meghnad Saha, Shanti Bhatnagar, Homi Bhabha, and their patron Jawaharlal Nehru—in the first half of the twentieth century before focusing on the evolution of the large and complex scientific community—especially Vikram Sarabhi—in the later part of the era. By contextualizing Indian debates over nuclear power within the larger conversation about modernization and industrialization, Anderson hones in on the thorny issue of the integration of science into the framework and self-reliant ideals of Indian nationalism. In this way, Nucleus and Nation is more than a history of nuclear science and engineering and the Indian Atomic Energy Commission; it is a unique perspective on the history of Indian nationhood and the politics of its scientific community.