Oecd Guidelines For The Testing Of Chemicals Section 4 Test No 419 Delayed Neurotoxicity Of Organophosphorus Substances 28 Day Repeated Dose Study

This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic ...

The test substance is administered orally in a single dose to domestic hens. The animals are observed for 21 days, then the remainder of the hens are killed and histopathological examination is undertaken. The young adult domestic laying hen (Gallus ...

This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...

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A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...

This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...

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This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...