Oecd Series On Testing And Assessment Guidance Document On Considerations For Waiving Or Bridging Of Mammalian Acute Toxicity Tests
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OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 19 |
Release | : 2017-04-13 |
Genre | : Electronic Book |
ISBN | : 9789264274754 |
Download OECD Series on Testing and Assessment Guidance Document on Considerations for Waiving or Bridging of Mammalian Acute Toxicity Tests Book in PDF, Epub and Kindle
Acute toxicity tests are an area of focus for developing alternative assays and approaches to address animal welfare concerns. In the context of this document, acute toxicity studies refer to studies involving a single exposure to a test chemical and include those assessing systemic toxicity as ...
OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 23 |
Release | : 2017-04-13 |
Genre | : Electronic Book |
ISBN | : 9789264274822 |
Download OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment Book in PDF, Epub and Kindle
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...
Chemical Testing Using New Approach Methodologies NAMs
Author | : Amy J. Clippinger,Tala Henry,Carole Hirn,Todd Stedeford,Andreas Stucki,Claire Terry |
Publsiher | : Frontiers Media SA |
Total Pages | : 139 |
Release | : 2022-12-16 |
Genre | : Science |
ISBN | : 9782832508596 |
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Nanocarriers for Drug Delivery
Author | : Josimar O. Eloy,Juliana Palma Abriata,Juliana Maldonado Marchetti,Juliana Maldonado Marchetti Hernandes |
Publsiher | : Springer Nature |
Total Pages | : 347 |
Release | : 2021 |
Genre | : Biomedical materials |
ISBN | : 9783030633899 |
Download Nanocarriers for Drug Delivery Book in PDF, Epub and Kindle
This book covers basic aspects of different nanoparticles, including type of materials, lipid, polymeric and inorganic structures, synthesis strategies, as well as the main physicochemical characterization techniques. Moreover, this book addresses applications for both treatment and diagnosis of diseases, highlighting in vitro and in vivo findings and clinical evaluation. The chapters highlight the main barriers for drug delivery which can benefit from nanoencapsulation: the topical and oral routes. The main innovations in the field, such as gene therapy and functionalization of nanoparticles with a variety of moieties, including monoclonal antibodies for selective delivery, are discussed and illustrated with examples. Finally, the application of nanoparticles for drug delivery to cancer is reviewed considering toxicology and regulatory aspects.
OECD Guidelines for the Testing of Chemicals Section 4 Test No 402 Acute Dermal Toxicity
Author | : OECD |
Publsiher | : OECD Publishing |
Total Pages | : 7 |
Release | : 2017-10-09 |
Genre | : Electronic Book |
ISBN | : 9789264070585 |
Download OECD Guidelines for the Testing of Chemicals Section 4 Test No 402 Acute Dermal Toxicity Book in PDF, Epub and Kindle
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Alternative Toxicological Methods
Author | : Harry Salem,Sidney A. Katz |
Publsiher | : CRC Press |
Total Pages | : 616 |
Release | : 2003-03-26 |
Genre | : Medical |
ISBN | : 9780203008799 |
Download Alternative Toxicological Methods Book in PDF, Epub and Kindle
Bringing together the recent and relevant contributions of over 125 scientists from industry, government, and academia in North America and Western Europe, Alternative Toxicological Methods explores the development and validation of replacement, reduction, and refinement alternatives (the 3Rs) to animal testing. Internationally recognized scientist
Assessing Risks to Endangered and Threatened Species from Pesticides
Author | : National Research Council,Division on Earth and Life Studies,Board on Environmental Studies and Toxicology,Committee on Ecological Risk Assessment Under FIFRA and ESA |
Publsiher | : National Academies Press |
Total Pages | : 194 |
Release | : 2013-06-20 |
Genre | : Nature |
ISBN | : 9780309285865 |
Download Assessing Risks to Endangered and Threatened Species from Pesticides Book in PDF, Epub and Kindle
The US Fish and Wildlife Service (FWS) and the National Marine Fisheries Service (NMFS) are responsible for protecting species that are listed as endangered or threatened under the Endangered Species Act (ESA) and for protecting habitats that are critical for their survival. The US Environmental Protection Agency (EPA) is responsible for registering or reregistering pesticides under the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and must ensure that pesticide use does not cause any unreasonable adverse effects on the environment, which is interpreted to include listed species and their critical habitats. The agencies have developed their own approaches to evaluating environmental risk, and their approaches differ because their legal mandates, responsibilities, institutional cultures, and expertise differ. Over the years, the agencies have tried to resolve their differences but have been unsuccessful in reaching a consensus regarding their assessment approaches. As a result, FWS, NMFS, EPA, and the US Department of Agriculture asked the National Research Council (NRC) to examine scientific and technical issues related to determining risks posed to listed species by pesticides. Specifically, the NRC was asked to evaluate methods for identifying the best scientific data available; to evaluate approaches for developing modeling assumptions; to identify authoritative geospatial information that might be used in risk assessments; to review approaches for characterizing sublethal, indirect, and cumulative effects; to assess the scientific information available for estimating effects of mixtures and inert ingredients; and to consider the use of uncertainty factors to account for gaps in data. Assessing Risks to Endangered and Threatened Species from Pesticides, which was prepared by the NRC Committee on Ecological Risk Assessment under FIFRA and ESA, is the response to that request.
Dictionary of Pharmaceutical Medicine
Author | : Gerhard Nahler |
Publsiher | : Springer Science & Business Media |
Total Pages | : 186 |
Release | : 2013-06-29 |
Genre | : Medical |
ISBN | : 9783709140161 |
Download Dictionary of Pharmaceutical Medicine Book in PDF, Epub and Kindle
This dictionary is aimed primarily at the beginners entering the new discipline of Pharmaceutical Medicine, an area comprising aspects of toxicology, pharmacology, pharmaceutics, epidemiology, statistics, drug regulatory and legal affairs, medicine and marketing. But also more experienced colleagues in departments engaged in clinical development as well as researchers and marketing experts in the pharmaceutical industry will find concise and up-to-date information. The book is completed by a list of a about 1000 abbreviations encountered in pharmaceutical medicine and a compilation of important addresses of national and international health authorities.