Pancreatitis And Its Complications

World-renowned experts and opinion-makers comprehensively review the clinical challenges of managing acute and chronic pancreatitis and explain the basic science that underlies these management strategies. The authors provide up-to-date discussions of the pathophysiology, epidemiology, diagnostic strategies, treatment, and complications of the diseases.

Diseases of the pancreas have been extremely difficult to study. Until relatively recently, the pancreas was viewed by surgeons as an organ to be avoided, given its deep retroperitoneal location and the sometimes severe consequences of manipulation. Similar difficulties have plagued careful study of the pancreas. In humans, only inf- quently have we had the opportunity to evaluate the evolution of d- eases of the pancreas; instead, we are confronted with end-stage chronic pancreatitis or acute pancreatitis with extensive necrosis of the gland. Within the past decade, revolutionary techniques in molecular biology, genetics, and animal models have begun to give us dramatic new insights into pancreatic disease. Coupled with these advances has been a slow but steady progress in the development of our clinical tools for diagnosing and treating pancreatic diseases. These advances place us on the threshold of a much more complete understanding of pancreatic diseases, opening up new opportunities for novel therapies and preventive measures. Pancreatitis and Its Complications brings together many of the world’s experts in pancreatic diseases. These “pancreatologists” include basic scientists, endoscopists, gastroenterologists, and surgeons. The ch- ters have been organized to provide a comprehensive discussion of acute and chronic pancreatitis, with up-to-date discussions of pat- physiology, epidemiology, diagnostic strategies, treatment, and c- plications of disease. It is hoped that this text will serve as a useful reference for clinicians as well as provide a clinical background for scientists with an interest in pancreatic or related diseases.

Clinical Pancreatology Since the book Clinical Pancreatology for Practising Gastroenterologists and Surgeons was first published sixteen years ago, the knowledge and clinical management of pancreatic diseases have developed markedly. Thanks to the development of the translational research and the from bench to bedside concept, much progress from the lab has been applied to clinical practice. In addition, several highly relevant clinical trials published over the last years have resulted in the update and optimisation of clinical guidelines. A new and validated classification of severity and complications of acute pancreatitis is firmly rooted in clinical practice and has been the basis for the development of minimally invasive approaches to pancreatic necrosis. The etiopathogenic knowledge of chronic pancreatitis and other pancreatopaties, like that associated with diabetes mellitus, has developed significantly. Especially important has been the development of the field of cystic pancreatic tumours, which has been reflected in the publication of several guidelines and consensus reports over the last few years. Most research efforts have focused on pancreatic cancer, which have led and will further lead to a significant increase in the therapeutic armamentarium against this devastating disease. Finally, many newly published studies have changed the concept, causes, clinical relevance, diagnosis and treatment of exocrine pancreatic insufficiency. This new edition of Clinical Pancreatology for Practising Gastroenterologists and Surgeons has enjoyed the collaboration of the world’s leading experts in each of the areas of clinical pancreatology with the aim of facilitating gastroenterologists, surgeons, oncologists, internists, nutritionists, diabetologists, paediatricians, radiologists, pathologists and other specialists in their decision making when facing patients with pancreatic diseases in their daily clinical practice. All in all, this book supplies an indispensable update of the relevant aspects of clinical pancreatology.

Pancreatitis: medical and surgical management provides gastroenterologists and GI surgeons, both fully qualified and in training, with a focused, evidence-based approach to the most exciting developments in the diagnosis and clinical management of pancreatitis. Focusing mainly on the rapidly changing and innovative medical and surgical strategies to manage the disease, new surgical procedures such as endoscopic biliary intervention and minimally invasive necrosectomy to exciting new medical therapies like Antiprotease, Lexipafant, probiotics and enzyme treatment are all discussed. Full colour throughout, with over 250 colour illustrations and with reference to the latest clinical guidelines from the AGA, ACG and UEGW at all times, it is an essential consultation tool for all those managing patients with this increasingly common condition.

ix Preface Smart surgeons learn from their own mistakes, smarter surgeons learn from mistakes of others, some never learn . . . You are a resident, overworked and constantly tired; sitting down with your mentor for a brief tutorial. What do you want to get out of these few minutes? To organize your thoughts and approaches to the particular problem; to learn how he -the weathered surgeon -"tackles it"; to grasp a few practical "recipes" or "goodies" and take home a message or two; to laugh a bit and unwind. This is also our goal in this book. We hope that you are not repelled or offended by the non-formal character of this book. This is how emergency abdominal surgery is taught best, by trial and error and repetitions, with emphasis on basics. This is not a "complete" textbook, nor is it a cookbook type manual or discussion of case studies; neither is it a collection of detailed lecture notes or exhaustive lists. Instead, it consists of a series of informal, uncensored, chats between experienced surgeons and their trainees. No percentages, series, elaborated figures or complicated algorithms are included; only a surgeon's narrative, explaining how "he does it" -based on his experience and state of the art knowledge of the literature. No references are included as it was our aim to put down nothing which has not been experienced, confirmed and practiced in our own hands.

Acute pancreatitis (AP) is one of the most common disorders of the gastrointestinal tract to result in hospitalization. Although most patients with AP will experience an uneventful disease course, those that develop moderate-to-severe AP can be challenging to manage. Rapid recognition, accurate diagnosis and prediction of severity, together with appropriate treatment, are therefore key in achieving the best outcomes for patients and for preventing subsequent episodes of AP. Written by two pancreatologists with extensive experience of managing patients with AP as well as in clinical research, 'Fast Facts: Acute and Recurrent Pancreatitis' provides a comprehensive, evidence-based guide to: - The pathophysiology and etiology of AP - Fundamentals of diagnosis - Predicting the likely severity of an episode of AP - Monitoring and managing complications in the early and later stages of disease - Preventing recurrence This book will be of interest to all those who may be involved in the care of patients with AP, including internal medicine specialists, gastroenterologists, intensive care specialists, surgeons and endoscopists. Contents: • Pathophysiology • Epidemiology and etiology • Diagnosis • Prognosis • Definitions for complications and severity classification • Early management • Management of symptomatic collections • Management of other local complications • Preventing recurrence and monitoring for late complications after acute pancreatitis

Textbook of Surgery is a core book for medical and surgicalstudents providing a comprehensive overview of general andspeciality surgery. Each topic is written by an expert in thefield. The book focuses on the principles and techniques of surgicalmanagement of common diseases. Great emphasis is placed onproblem-solving to guide students and junior doctors through theirsurgical training. Throughout the book are numerous reproducible line drawings,tables and boxes that will prove invaluable for learning andrevision. In addition there are detailed guidelines provided forsurgical management. Up-to-date and ideal for medical students and junior doctors onsurgical attachments and a perfect refresher for RACS and MRCScandidates. Reviews of the last edition “The textbook presents a compact and contemporary overviewand is not so much a reference book as a working tome suitable forfamiliarization with current trends in treatment and diagnosis inthese various areas. …found this textbook very informative and a pleasure toread.” ANZ Journal of Surgery Vol. 72, No. 12.