Parasiticide Screening

Parasiticide Discovery: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods, Volume One presents valuable screening methods that have led to the discovery of the majority of parasiticides commercialized in the animal health industry. As much of the knowledge of parasiticide discovery methods is being lost in the animal health industry as seasoned parasitologists retire, this book serves to preserve valuable methods that have led to the discovery of the majority of parasiticides commercialized in animal health, also giving insights into the in vitro and in vivo methods used to identify the parasiticide activity of compounds. Addresses current issues of resistance, along with combination uses for resistant parasites Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds Includes a discussion on screening methods in combination therapies Provides cutting-edge material for an evolving area of scientific discussion Includes in vitro and in vivo screens and parasite maintenance and culture methods

Parasiticide Discovery: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods, Volume Two presents valuable screening methods that have led to the discovery of the majority of parasiticides commercialized in the animal health industry. As much of the knowledge of parasiticide discovery methods is being lost in the animal health industry as seasoned parasitologists retire, this book serves to preserve valuable methods that have led to the discovery of the majority of parasiticides commercialized in animal health, also giving insights into the in vitro and in vivo methods used to identify the parasiticide activity of compounds. Addresses current issues of resistance, along with combination uses for resistant parasites Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds Includes a discussion on screening methods in combination therapies Provides cutting-edge material for an evolving area of scientific discussion Includes in vitro and in vivo screens and parasite maintenance and culture methods

Parasiticide Discovery: In Vitro and In Vivo Tests with Relevant Parasite Rearing and Host Infection/Infestation Methods, two-volume set, presents valuable screening methods that have led to the discovery of the majority of parasiticides commercialized in the animal health industry. As much of the knowledge of parasiticide discovery methods is being lost in the animal health industry as seasoned parasitologists retire, this book serves to preserve valuable methods that have led to the discovery of the majority of parasiticides commercialized in animal health, also giving insights into the in vitro and in vivo methods used to identify the parasiticide activity of compounds. Addresses current issues of resistance, along with combination uses for resistant parasites Presents useful, authoritative information (chemical, pharmaceutical, clinical, etc.) for the pyrantel family of compounds Includes a discussion on screening methods in combination therapies Provides cutting-edge material for an evolving area of scientific discussion Includes in vitro and in vivo screens and parasite maintenance and culture methods

Poultry Coccidiosis is a valuable, comprehensive reference that reviews the biology of coccidia, covers current diagnostic and testing procedures, and thoroughly covers the anti-coccidial vaccines and drugs that are currently available. This user-friendly guide will provide poultry scientists, poultry disease diagnosticians, and veterinary practitioners with a well-illustrated description of the Johnson and Reid scoring procedure, thorough explanation of laboratory procedures, experiment design, example protocols for testing anticoccidial drugs, a summary of the chemical name, structure, safety, and efficacy of anticoccidial drugs, and a review of anticoccidial vaccines that are currently available. This easy-to-use reference will be an invaluable tool for anyone working with poultry.

Pyrantel Parasiticide Therapy in Humans and Domestic Animals presents a single source history and reference on the parasiticide activity and pharmacology of the tetrahydropyrimidines and their salts in humans and domestic animals, also collating evidence that resistance to pyrantel has developed in human and domestic animal nematodes. Other books of this nature have been compiled historically for specific anthelmintic compounds, but none has been written to date for the pyrantel family of drugs. Pyrantel, a nicotinic receptor agonist, has been used in domestic animal and human medicine since the 1970's to control two important nematode groups, the hookworms and the roundworms. Given the zoonotic potential of these parasites, pyrantel has served a dual role in helping to protect the health of both domestic animals and the public for more than 45 years.

The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Issues for Sept. 1933- contain a section on research notes.