Penile Cancer

The aim of the updated book is to include new developments and update the literature in relation to sentinel node biopsy, new radiology techniques and long term epidemiological data. This book is useful for urologists, dermatologists, sexual health physicians as well as those with an interest in virology and genomics related to squamous cell cancers. The surgical techniques are all well illustrated with a step by step guide in order to allow those individuals in centres which are not expert centres to undertake the management of this devastating tumour.

This book provides a comprehensive and state-of the-art approach to caring for penile carcinoma patients and provides foundational information related to the molecular pathways implicated in penile carcinogenesis and progression. Penile carcinoma remains one of the most debilitating and life-altering malignancies to affect men, with significant impacts on quality of life, erectile function/sexual activity, and length of life. This book illuminates recent advances in penile cancer sparing treatment approaches and oncologically appropriate therapeutic options that help to maintain quality of life, sexual function, and intimacy for patients. It also elucidates recent understandings of human papilloma virus (HPV) and non-HPV driven pathways, which are suspected to have distinct treatment responses and prognoses. The book explores the management of inguinal lymph nodes in the setting of penile cancer, which can now be managed with the integration of key surgical principles/techniques including the adoption of minimally invasive surgery. Considering a multidisciplinary treatment approach for patients exhibiting either locally advanced or more widespread metastatic disease, the book introduces novel systemic therapies currently in development. Further, this book raises clinician awareness of the significant psychosocial impact of penile carcinoma on patients and their families. Penile Carcinoma: Therapeutic Principles and Advances provides readers with the necessary knowledge and insight to care for penile cancer patients with the use of truly state-of-the-art diagnostic and therapeutic approaches. Cancer patients and their families will greatly benefit from adoption of these principles and the accessibility of such advances to their personalized care.

This fully updated and revised second edition address specifically some of the significant advances made in our understanding of the pathophysiology of penile cancer including discussion of the suspected role of the human papilloma virus in penile carcinogenesis. Similarly, the molecular pathways implicated in precancerous and penile cancer will be discussed as these are the present targets of novel therapeutic approaches to this disease. The text details the recent national and international diagnostic and treatment guidelines that have been developed by both the National Comprehensive Cancer Network© and the European Urological Association establishing evidence based standards upon which the care of penile cancer should be based. The text also covers significant advances made in the diagnostic and therapeutic approach to both primary tumors and inguinal nodal metastases resulting from penile cancer such as penile sparing surgery and minimally invasive inguinal lymph node surgery. The text will similarly highlights the improvement in cancer specific outcome in the management of loco-regionally advanced (N2/3) penile cancer managed by upfront systemic chemotherapy followed by consolidative surgery in appropriately selected patients based on recent prospective phase II data. It also covers the role of radiotherapy in the management of penile cancer for both primary tumors and/or at sites of regional or distant metastases. Finally, some of the novel systemic approaches being devised in the management of advanced penile cancer along with some upcoming international trials soon to be opened which likely will re-define the present therapeutic approaches to penile cancer are discussed. The Second Edition of Penile Cancer: Diagnosis and Treatment will constitute a comprehensive review of the above mentioned subjects in addition to a few select topics of high clinical relevance, with the readership predominantly consisting of urologists, medical and surgical oncologists, and other healthcare professionals.

Aims and Scope: Although penile cancer is uncommon in the industrialized world, it is highly prevalent in certain regions of the globe such as South America, Africa, and Southeast Asia. It is a highly aggressive malignancy which is often associated with a long delay until diagnosis. This is frequently attributed to shame, fear, and ignorance of the patient. In more advanced stages, it may require extensive amputative surgery that is devastating both physically and psychologically with enormous impact on quality of life, such as loss of conjugal intimacy and self-esteem. On the contrary, in the early stages surgical resection and subsequent disfigurement can be minimized and associated with good cosmetic results. Therefore, it is both patient's and physician's task to identify the disease early as the negative impact of the treatment is undoubtedly reduced. This fact emphasizes the importance of education of the patient, primary care physician and thepublic in general, and should get the proper attention from both the medical and lay media. Simple routine habits like self-examination and desired hygiene will facilitate early diagnosis and prevention.Although penile cancer has undergone significant advances in the field of diagnosis and multidisciplinary treatment in the past two decades, several challenges and controversies still remain unsolved. Diagnostic evaluation and management of less clinically evident disease requires better standardization of practice. Similarly, minimizing adverse sequelae related to interventions cannot be overemphasized. The implementation of multidisciplinary centers of excellence focused on the nuances inherent to an uncommon but aggressive disease will significantly aid to improve treatment outcomes and quality of life. Each chapter's senior author was hand-selectedas a world class resource for the area of expertise and for their willingness to share their surgical insight and wisdom. This book will have contributions from world-renowned experts in this field from different continents, providing an international flare and perspective on the recent developments in the field of diagnosis and treatment penile cancer as well as reconstruction of the devastating effects of penile mutilation, including the recent interest in phallic reconstruction and ultimately penile transplantation for the penile cancer survivor. This book will also highlight other current challenges and controversies surrounding this disease, especially those related to the management of locally advanced and metastatic involvement.This book, with its multidisciplinary approach, is intended to provide a comprehensive discussion and benefit every reader, junior or senior, world over who is interested in and deals with patients afflicted by penile cancer, including the urologic oncologist, the radiation oncologist, the medical oncologist, the urology resident, and last but not least the primary care physician.

Management of Penile Cancer provides a comprehensive and state-of-the-art overview of the major issues specific to the field of penile cancer. The sections of the book are structured to review the overall scope of issues of penile cancer, including diagnosis and staging, surgical approaches and the treatment of advanced disease. As multidisciplinary care is an integral part of the treatment of penile cancer, this book is unique in the inclusion of collaborating authors from a variety of integrated disciplines, including urology, radiation oncology, medical oncology and reconstructive surgery. Written by recognized experts in their field, Management of Penile Cancer is a unique and valuable resource in the field of penile cancer, both for those currently in training and for those already in clinical or research practice.

Testicular and Penile Cancer outlines the initial surgical approaches and treatment options such as chemotherapy and radiation for patients with these diseases. It is a practical guide providing epidemiological, diagnostic and therapeutic management details to faciliate optimal treatment of testicular and penile cancers.

Textbook of Penile Cancer reports accurately on recent developments in the management of penile cancer, whilst also covering the fundamentals of the disease, to provide a comprehensive, stand-alone and up-to-date volume on the subject. The surgical management of penile cancer is shifting towards increasingly refined methods, as it is believed that a proportion of patients undergo overtreatment for the disease. Where traditionally the management of penile cancer has involved partial or total penectomy combined with radical inguinal lymphadenectomy, over the last few years the treatment involves conservative penile reconstructive surgery such that sexual function and phallic length is preserved. Furthermore, the increasing utilization of sentinel lymph node biopsy rather than radical inguinal lymphadenectomy prevents the unnecessary removal of lymph nodes in patients where lymph node metastases has not occurred. There is also likely to be a change in the role of chemotherapy and radiotherapy for advanced disease. Textbook of Penile Cancer covers the epidemiology, molecular biology, radiological imaging, as well as the latest surgical advances in the treatment of this disease. This book is a valuable reference tool for Urological Surgeons, Genitourinary Physicians, Trainee Surgeons, Plastic Surgeons, Oncologists, Dermatologists and Sexual Health Physicians.

The aim of the updated book is to include new developments and update the literature in relation to sentinel node biopsy, new radiology techniques and long term epidemiological data. This book is useful for urologists, dermatologists, sexual health physicians as well as those with an interest in virology and genomics related to squamous cell cancers. The surgical techniques are all well illustrated with a step by step guide in order to allow those individuals in centres which are not expert centres to undertake the management of this devastating tumour.