Peptide And Protein Drug Delivery
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Peptide and Protein Delivery
Author | : Chris Van Der Walle |
Publsiher | : Academic Press |
Total Pages | : 380 |
Release | : 2011-05-12 |
Genre | : Science |
ISBN | : 0123849365 |
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The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary / collaborative projects, Peptide and Protein Delivery addresses the current and emerging routes for delivery of therapeutics. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Discusses the most recent data, ideas and concepts Presents case studies and an industrial perspective Details information from the molecular level to bioprocessing Thought provoking, for the novice to the specialist Timely, for today's biopharmaceuticals market
Peptide and Protein Drug Delivery
Author | : Vincent Lee |
Publsiher | : CRC Press |
Total Pages | : 916 |
Release | : 1990-11-19 |
Genre | : Science |
ISBN | : 0824778960 |
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This reference/text covers fundamentals of peptide and protein drug delivery, including such considerations as synthesis, physical chemistry and biochemistry, analysis, proteolytic and transport constraints, pharmacokinetics, and pharmacodynamics; bioavailability from routes of administration, detai
Trends and Future Perspectives in Peptide and Protein Drug Delivery
Author | : Vincent Lee |
Publsiher | : CRC Press |
Total Pages | : 400 |
Release | : 1995-02-01 |
Genre | : Medical |
ISBN | : 3718656418 |
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First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.
Biological Barriers to Protein Delivery
Author | : Kenneth L. Andus,Thomas L. Raub |
Publsiher | : Springer Science & Business Media |
Total Pages | : 507 |
Release | : 2012-12-06 |
Genre | : Medical |
ISBN | : 9781461528982 |
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In response to the tremendous increase in the number of protein and peptide drugs, this treatise critically reviews transport and metabolism mechanisms relating to the delivery of endogenous and recombinant proteins to mammalian organs, tissues, and cells. It will promote fruitful collaboration among academic and industrial scientists in the fields of pharmacology, cell biology, biochemistry, physiology, and immunology.
Therapeutic Peptides and Proteins
Author | : Ajay K. Banga |
Publsiher | : CRC Press |
Total Pages | : 400 |
Release | : 2015-04-23 |
Genre | : Medical |
ISBN | : 9781466566071 |
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There are more than 500 biopharmaceuticals on the market, including more than 200 therapeutic proteins, making biologics the fastest growing sector in the biopharmaceutical market. These products include more than 40 monoclonal antibodies, for indications ranging from treatment or mitigation of various types of cancer to rheumatoid arthritis. The clinical application of these therapeutic peptides and proteins is limited by several problems, such as lack of physical and chemical stability or the lack of desirable attributes for adequate absorption or distribution. Thus, as these therapeutic peptides and proteins are made available, it will be essential to formulate these drugs into safe, stable, and efficacious delivery systems. The pharmaceutical scientist involved in this effort needs to call upon the knowledge of several disciplines, such as pharmaceutics, medicinal chemistry, biochemistry, microbiology, and chemical engineering and needs to keep abreast with the latest research in the published literature. Therapeutic Peptides and Proteins: Formulation, Processing, and Delivery Systems, Third Edition provides a comprehensive overview of the field for scientists in industry and academia and for students, while also providing practical information on the challenges facing the formulation and delivery aspects of these unique macromolecules. In particular, the book: Explains how recombinant DNA techniques now allow us to produce therapeutic proteins in a commercially viable form Discusses the physical and chemical pathways of peptide and protein degradation Includes a detailed discussion of protein formulation and lyophilization Overviews the pharmacokinetic aspects of therapeutic peptides and proteins and discusses controlled delivery systems for parenteral administration, including microsphere formulations Discusses research progress on oral, transdermal, mucosal, and topical delivery systems discusses transdermal and topical delivery
Proteins and Peptides
Author | : Randall J. Mrsny,Ann Daugherty |
Publsiher | : CRC Press |
Total Pages | : 288 |
Release | : 2009-10-19 |
Genre | : Medical |
ISBN | : 9781420078077 |
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Addressing the increased use of protein and peptide candidates as treatments for previously untreatable diseases, this comprehensive and progressive source provides the reader with a roadmap to an increased understanding of issues critical for successfully developing a protein or peptide therapeutic candidate. Proteins and Peptides is
Peptide Drug Delivery to the Brain
Author | : William M. Pardridge |
Publsiher | : Raven Press (ID) |
Total Pages | : 378 |
Release | : 1991 |
Genre | : Medical |
ISBN | : UOM:39015022016532 |
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Discusses new and established strategies for delivering peptides and antibodies through the blood-brain barrier. It reviews concepts on blood-brain barrier transport biology, assesses the utility and limitations of traditional brain drug delivery methods and describes new drug delivery techniques.
Delivery Systems for Peptide Drugs
Author | : S.S. Davis,Lisbeth Illum,E. Tomlinson |
Publsiher | : Springer Science & Business Media |
Total Pages | : 363 |
Release | : 2013-11-11 |
Genre | : Medical |
ISBN | : 9781475799606 |
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Recent years have seen enormous advances in the field of protein and peptide engineering and a greater understanding in the way in which biological response modifiers function in the body. It is now possible through the use of recombinant DNA techniques, or by solid phase protein synthesis, to produce significant quantities of a wide variety of regulatory agents that are therapeutically applicable. The list of these response modifiers expands almost daily to include interferons, macrophage activation factors, neuropeptides and agents that may have potential in cardiovascular disease, inflammation, contraception etc. Prospects to use some of these materials in medicine have reached the stage where products have either been approved by regulatory authorities or are the subject of applications as investigatory drugs or as new therapeutic agents. In some uses the pertinent agent will be administered on an acute basis in the form of a simple injection, as, for example, the use of a tissue plasminogen activator for the treatment of coronary infarct. In other cases regulatory proteins and peptides are indicated for chronic therapy and here they will need to be administered by an appropriate delivery system. Unfortunately, the research on delivery systems for peptides and proteins has not kept pace with the rapid progress in biotechnology and, consequently, there are presently few systems that are entirely appropriate for the administration of macromolecular drugs according to complex dosage regimens, (eg intermittent and pulsed therapy). Furthermore essential pharmacokinetic and pharmacodynamic data may be missing.